Posted on 07/24/2023 10:07:33 AM PDT by ConservativeMind
RUSH researchers recently discovered that a muscle-building supplement called beta-hydroxy beta-methylbutyrate, also called HMB, may help protect memory, reduce plaques and ultimately help prevent the progression of Alzheimer's disease.
HMB is not a prescription drug or a steroid, but an over-the-counter supplement that is available in sports and fitness stores. Bodybuilders regularly use HMB to increase exercise-induced gains in muscle size and strength while improving exercise performance. HMB is considered safe even after long-term use, with no known side effects.
"This may be one of the safest and the easiest approaches to halt disease progression and protect memory in Alzheimer's disease patients," said Kalipada Pahan, Ph.D.
Studies in mice with Alzheimer's disease have shown that HMB successfully reduces plaques and increases factors for neuronal growth to protect learning and memory, according to neurological researchers at RUSH.
Previous studies indicate that a family of proteins known as neurotrophic factors are drastically decreased in the brains of people with Alzheimer's disease and have been found to help in survival and function of neurons, which are cells that receive and send messages from the body to the brain and vice versa.
"Our study found that after oral consumption, HMB enters into the brain to increase these beneficial proteins, restore neuronal connections and improve memory and learning in mice with Alzheimer's-like pathology, such as plaques and tangles," Pahan said.
The study findings indicate that HMB stimulates a nuclear hormone receptor called PPARα within the brain that regulates the transport of fatty acids, which is key to the success of HMB as a neuroprotective supplement.
"If mouse results with HMB are replicated in Alzheimer's disease patients, it would open up a promising avenue of treatment of this devastating neurodegenerative disease," Pahan said.
(Excerpt) Read more at medicalxpress.com ...
Wow this is great news.
10 years ago, weren’t they saying this stuff was bad for you?
HMB helps build lean muscle mass, but has no effect on fat mass, which unfortunately I have in greater abundance.
(FYI, it doesn’t stand for “hug me, Brandon”)
wHoley Memory, Batman!
Ooops, better get that stuff off the market until a patented and FDA trialed version is developed.
Signed,
Your favorite pharmaceutical company
Thanks. This stuff is probably all over good for older brains.
Interesting. That it’s just now being noticed.
I wonder what the dosage is. One supplement site has 1000mg caps, 3x/day, 90 caps for around $40.
They got good results with just 10 mg/kg of weight.
That would be just 230 mg of HMB for every 50 pounds of weight.
For a 200 pound person, that would be 920 mg or basically just one gram.
You have to subtract out the calcium content, I just noticed, which means a 200 pound person would need about 1.25 grams (1,250 mg) to equal the dose they got the best response with, in their experiments.
Interestingly, you get a lot of calcium from this.
If this pans out it is Hugh!
Thank you.
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