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New treatment method reduces size and increases stability of atherosclerotic plaque on arterial walls (Liposomal Omega-3 DHA)
Medical Xpress / National University of Singapore / Journal of Controlled Release ^ | Aug. 7, 2022 | Suet Yen Chong et al

Posted on 08/10/2023 8:31:05 AM PDT by ConservativeMind

Atherosclerosis is a disease in which fat, cholesterol, and other substances build up inside artery walls. This can can block arteries and cause heart attacks and strokes.

Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been shown to have anti-inflammatory and antioxidant properties, which could help to prevent the buildup of fatty deposits in arteries— a major cause of heart attacks and strokes. DHA supplements are often consumed orally, but most are poorly absorbed by the gut. . To improve the absorption, a research team worked on laboratory models to deliver DHA to the bloodstream that could be more effective than oral consumption–via DHA liposomes.

DHA liposomes, are small vesicles made up of phospholipids, a major membrane lipid which acts as a barrier to protect the cell against various adverse environmental conditions. The liposomes can help to reduce the size of plaques and the amount of inflammation in arteries. When delivered into the blood stream, DHA liposomes accumulate in the plaques on the arterial walls.

The research team found that macrophages, a type of white blood cell, absorb the DHA liposomes, resulting in reduced inflammation and increased healing of the atherosclerotic plaques. These liposomes also help reduce the amount of lipids in the build-up and prevent its rupture.

The researchers employed a state-of-the-art mass spectrometry imaging technology to analyze the plaque. It revealed that DHA liposomes can restore the lipid balance in the artery to that of healthy arteries in which less harmful lipids are present. These results suggest that DHA liposomes could be a promising new treatment for atherosclerosis.

"This is the first study to demonstrate that an injectable nanoformulation can remarkably improve the therapeutic effects of DHA against atherosclerosis at a dose of 40,000 to 400,000 times lower than reported usage of oral DHA," said Asst Prof Wang.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: artery; cholesterol; dha; liposomes
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Liposomal “anything” is typically the substance you want absorbed, surrounded by a component of lecithin. Lecithin is in egg yolks, and a variety of other foods. Lecithin, via its phospholipids, can greatly enhance intestinal absorption of what it surrounds.

This was an incredibly small amount of liposomal DHA that was injected. There is a form of liposomal DHA available for oral use, and it might be helpful, but having the liposomal form already in the blood stream means it is more inclined to further pass through the vessel wall to where it’s needed. The oral liposomal form, in my understanding, has its liposomal form lost, as it’s absorbed.

A form of oral liposomal DHA is available from MaryRuth Organics.

1 posted on 08/10/2023 8:31:05 AM PDT by ConservativeMind
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To: ConservativeMind

“reduces size ... of atherosclerotic plaque”

Well that’s one way. But what if we just make the arteries bigger?


2 posted on 08/10/2023 8:36:12 AM PDT by Boogieman
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To: ConservativeMind

“Lecithin is in egg yolks, and a variety of other foods.”

It’s basically the most common “emulsifier”. “Soy lecithin” is what you’ll usually see on food labels. Basically, it can help two substances that are not mutually soluable stay mixed together in suspension, when they would normally separate. That’s why some peanut butters (the more organic/natural kind) will separate into oil and nut paste if they sit for awhile, while the Jif and Peter Pan will not (because they have lecithin or some other emulsfier added).


3 posted on 08/10/2023 8:38:53 AM PDT by Boogieman
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To: ConservativeMind

Vescepa which is a pure EPA Omega 3 does the same with prolonged use. 17% reduction after 18 months.


4 posted on 08/10/2023 8:45:24 AM PDT by DAC21
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To: ConservativeMind
Very interesting. I searched for liposomal DHA and found this 2016 paper that has similar conclusions as the one you posted (except it did not study arterial plaques). It specifically proposed intravenous delivery of ω-liposomes.
Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment
2016 Oct 5
By Amr Alaarg, Nan Yeun Jordan, Johan JF Verhoef, Josbert M Metselaar, Gert Storm, and Robbert J Kok

ABSTRACT

Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis and cancer. ω3 polyunsaturated fatty acids (PUFAs; also known as omega3 fatty acids or fish oil) have beneficial effects against inflammation upon dietary consumption. However, these effects cannot be fully exploited unless diets are enriched with high concentrations of fish oil supplements over long periods of time. Here, a nanomedicine-based approach is presented for delivering effective levels of PUFAs to inflammatory cells. Nanoparticles are internalized by immune cells, and hence can adequately deliver bioactive lipids into these target cells. The ω3 FA docosahexaenoic acid was formulated into liposomes (ω-liposomes), and evaluated for anti-inflammatory effects in different types of immune cells. ω-Liposomes strongly inhibited the release of reactive oxygen species and reactive nitrogen species from human neutrophils and murine macrophages, and also inhibited the production of the proinflammatory cytokines TNFα and MCP1. Moreover, ω-liposomes inhibited tumor-cell proliferation when evaluated in FaDu head and neck squamous carcinoma and 4T1 breast cancer cells in in vitro cultures. We propose that ω-liposomes are a promising nanonutraceutical formulation for intravenous delivery of fish oil FAs, which may be beneficial in the treatment of inflammatory disorders and cancer.


5 posted on 08/10/2023 8:47:48 AM PDT by ProtectOurFreedom (We are proles, they are nobility.)
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To: ConservativeMind

“Injectable nanoformulation…” Yeah, hard pass.


6 posted on 08/10/2023 8:59:00 AM PDT by ponygirl (Stay gold.)
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To: ConservativeMind

Nattokinase can reduce the area of atherosclerotic plaque. Also, it has been shown that nattokinase can reduce atherosclerosis to a greater extent than the statin therapy (powerful lipid-lowering drugs). Nattokinase inhibits aggregation of platelets, additionally supressing the blood clot formation.

“Natto” is a Japanese food made of fermented soy beans. While as such it does not taste particularly good, the slime that forms between the beans, the nattokinase, can be dried and processed into a tasteless powder, and is taken in pill form.

It is good both in safely dissolving blood clots and atherosclerotic plaque, and preventing their reformation, so it is an inexpensive treatment against clots, ischemic stroke and some types of heart attack.


7 posted on 08/10/2023 8:59:04 AM PDT by yefragetuwrabrumuy ("All he had was a handgun. Why did you think that was a threat?" --Rittenhouse Prosecutor)
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To: ponygirl

rich people are taking vitamins/supplements by IV


8 posted on 08/10/2023 9:26:24 AM PDT by Karoo
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To: Karoo

I take vitamins/supplements by IV and I am certainly not rich. I’m just informed and aware of their anti-human agenda. And any Frankenstein-nanoparticle BS is a No from me.


9 posted on 08/10/2023 9:30:55 AM PDT by ponygirl (Stay gold.)
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To: ConservativeMind

The Docosahexaenoic acid (DHA) that I take has 838 mg. Is that enough?


10 posted on 08/10/2023 10:06:59 AM PDT by jonrick46 (Leftniks chase illusions of motherships at the end of the pier.)
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To: yefragetuwrabrumuy

Is this similar to roasted soy bean powder? I bought a bag of it awhile back.


11 posted on 08/10/2023 10:10:19 AM PDT by magna carta
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To: ConservativeMind

Of course, as with anything coming from Big Pharma nowadays, one needs to THINK DEVIOUSLY as to how, maybe, such substances/compounds/etc. might be adulterated with all kinds of “bonus material”.
I refer to DNA, mRNA or whatever “the power behind the throne” wants you to receive.
What a world!! Science fiction of the last two centuries was only a hint in terms of where we are today.


12 posted on 08/10/2023 10:19:37 AM PDT by Honest Nigerian
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To: magna carta

Probably not, even if it is fermented. The goody is not in the beans, but the slime. However, there are a bunch of retailers on Amazon.


13 posted on 08/10/2023 10:20:33 AM PDT by yefragetuwrabrumuy ("All he had was a handgun. Why did you think that was a threat?" --Rittenhouse Prosecutor)
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To: ponygirl

Wait until they require that you take your Docosahexaenoic acid by IV. Any failure to do so will result in ones loss of medical coverage. Nanocircuits in those injections will transmit data on ones health status and substance intake. Violations of the intake protocol will cause a freeze on ones bank account. SWAT teams will break ones door down and take them to a holding cell. One will be held as long as it takes for data showing they have returned to normal status—in the year 2084.


14 posted on 08/10/2023 10:41:24 AM PDT by jonrick46 (Leftniks chase illusions of motherships at the end of the pier.)
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To: ConservativeMind

Thanks.
BKMK


15 posted on 08/10/2023 11:13:04 AM PDT by Faith65 (Isaiah 40:31 )
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To: yefragetuwrabrumuy

Nothing to stop anyone from taking them both!


16 posted on 08/10/2023 11:53:34 AM PDT by Pete from Shawnee Mission ( )
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To: ConservativeMind

Ping


17 posted on 08/10/2023 4:56:47 PM PDT by AnglePark (My opinion is the most worthless thing I own.)
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...
I missed a ping!


The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

18 posted on 11/14/2023 10:54:03 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: DAC21

For completeness:


WHAT ARE THE POSSIBLE SIDE EFFECTS OF VASCEPA?
VASCEPA may cause serious side effects, including:
Heart rhythm problems (atrial fibrillation and atrial flutter). Heart rhythm problems which can be serious and cause hospitalization have happened in people who take VASCEPA, especially in people who have heart (cardiovascular) disease or diabetes with a risk factor for heart (cardiovascular) disease, or who have had heart rhythm problems in the past. Tell your doctor if you get any symptoms of heart rhythm problems such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, chest discomfort or you faint.

Possible allergic reactions if you are allergic to fish or shellfish. Stop taking VASCEPA and tell your doctor right away or get emergency medical help if you have any signs or symptoms of an allergic reaction.

Bleeding. Serious bleeding can happen in people who take VASCEPA. Your risk of bleeding may increase if you are also taking a blood thinner medicine.


19 posted on 11/15/2023 3:55:40 AM PST by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
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To: Boogieman

“ what if we just make the arteries bigger?”

Stents. Lots of stents back to back.


20 posted on 11/15/2023 6:25:20 AM PST by ProtectOurFreedom (“Occupy your mind with good thoughts or your enemy will fill them with bad ones.” ~ Thomas More)
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