Posted on 09/15/2023 7:56:27 PM PDT by ConservativeMind
Researchers who previously developed the first 3D human cell culture models of Alzheimer's disease (AD) that displays two major hallmarks of the condition—the generation of amyloid beta deposits followed by tau tangles—have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.
The team has uncovered promising results suggesting that irisin-based therapies might help combat AD.
Exercise increases circulating levels of the muscle-derived hormone irisin, which regulates glucose and lipid metabolism in fat tissue and increases energy expenditure by accelerating the browning of white fat tissue.
Studies have revealed that irisin is present in human and mouse brains and that its levels are reduced in patients with AD and in mouse models of the condition.
To test whether irisin plays a causal role in the link between exercise and reduced amyloid beta, Se Hoon Choi, Ph.D. applied the hormone to their 3D cell culture model of AD.
"First, we found that irisin treatment led to a remarkable reduction of amyloid beta pathology," says Choi. "Second, we showed this effect of irisin was attributable to increased neprilysin activity owing to increased levels of neprilysin secreted from cells in the brain called astrocytes."
Neprilysin is an amyloid beta–degrading enzyme that has been found to be elevated in the brains of mice with AD that were exposed to exercise or other conditions leading to reduced amyloid beta.
Previous studies have shown that in mice, irisin injected into the blood stream can make its way into the brain, making it potentially useful as a therapeutic.
"Our findings indicate that irisin is a major mediator of exercise-induced increases in neprilysin levels leading to reduced amyloid beta burden, suggesting a new target pathway for therapies aimed at the prevention and treatment of Alzheimer's disease," says Rudolph Tanzi, Ph.D.
(Excerpt) Read more at medicalxpress.com ...
Fasting works for me. Exercise, intermittent fasting, raising your testosterone levels and abstaining from statins would do more good than anything else. Read and exercise your mind or play chess. Stay mentally healthy. Meditation and blocking out negative thoughts are beneficial for everybody.
I am living proof of that. At age 83, I am still writing complex computer programs, managing my investments, and do not need a single prescription. Regular exercise is amazing benefit for delaying old age issues. I do this simple exercise 4 days every week for 30 minutes.
https://youtube.com/shorts/cOZbElfBdCU?
Good for you...following in your footsteps... at 81.
bookmark
BTTT
Do you do that to music?
https://today.duke.edu/2015/03/irisin-myth
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The discovery of the “exercise hormone” irisin three years ago and more than 170 related papers about it since have been called into question by recent research showing they were based on flawed testing kits....
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Good tips!
Yes! Music gets me in the mood to make dancing moves.
Otherwise treadmill is very boring exercise.
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