Posted on 10/08/2023 8:25:55 AM PDT by ConservativeMind
Obesity often involves hyperlipidemia (high concentrations of fats/lipids in the blood), diabetes, hypertension, chronic inflammation and oxidative stress, which increase susceptibility to CVD.
Low-density lipoprotein (LDL) is a nanoparticle that transports cholesterol in blood. Cholesterol, which is good in moderation, is essential for normal cellular function.
"Our results showed that in obesity, it is not the quantity but the quality of LDL that contributes to disease: 'bad cholesterol' becomes worse due to obesity-associated inflammation. As a result, cholesterol delivery is shifted from normal to abnormal, so more cholesterol is retained in the arterial wall, ultimately forming plaques that occlude the blood flow," explained Shobini Jayaraman, Ph.D.
In the study, blood lipoproteins from patients with severe obesity before bariatric surgery and 6 or 12 months after were compared with lipoproteins from a control group of lean healthy subjects.
In patients with obesity, they found LDL particles became dysfunctional and were less efficient at delivering their cholesterol cargo to LDL receptors. Additionally, the LDL particle also tended to either preferentially deliver cholesterol to scavenger receptors or stick to the arterial wall matrix. "This aberrant behavior stemmed from alterations in LDL biochemical composition induced by obesity-associated inflammation. These harmful changes contributed to increased risk of CVD in patients with obesity," added Jayaraman.
According to the researchers, during the first year after the bariatric surgery the patients lost a lot of weight, the obesity-induced inflammation subsided, and the LDL quality progressively improved 6 and 12 months post-operatively.
"Our study shows that LDL quality continues to improve as a patient's weight normalizes, suggesting that the risk of CVD continues to decline. This is promising not only for patients undergoing bariatric surgery but perhaps for many others who are overweight or obese and use various approaches to weight loss," said Olga Gursky, Ph.D.
(Excerpt) Read more at medicalxpress.com ...
There are various subclasses of LDL.
as if these meth users don't have health problems...or smokers....
“However you do it, getting your fat under control changes the LDL quality to a healthier form.”
My understanding is that it’s the LDL Particle Size that determines the danger. Small Particles are the threat, larger ones are low risk. No doubt losing weight is effective, but the Small Particles come from carbs, so limiting carbs is also effective.
Anyway, at least they’re now talking about differences in LDL, which is a good thing...although it will take another 20 years to filter that down to the doctors.
This makes sense. It’s the quality, not quantity. Also raises the fire vs. firefighter issue, due to inflammation.
Obesity has a high correlation with many, many health problems...from COVID to Maternal Death and Infant Death and Lung disease and Heart disease and on and on.
Americans are more obese than other civilized areas and that is the #1 reason we have worse health statistics than others.
Although that could be debateable if you join substance abuse of all types of substance abuse.
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