Posted on 04/11/2024 9:46:06 PM PDT by ConservativeMind
A new meta-analysis shows sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of major adverse cardiovascular events in patients with either diabetes at high risk of atherosclerotic cardiovascular disease (ASCVD), heart failure, or chronic kidney disease (CKD).
SGLT2 inhibitors, also called gliflozins, are a class of drug that lower blood glucose by increasing its excretion in the urine. While late-stage trials of these medicines have demonstrated reductions in heart failure and adverse kidney outcomes, the effects on major adverse cardiovascular events (MACE), including cardiovascular death, myocardial infarction, and stroke, were less clear.
Researchers analyzed data across 11 trials involving 78,607 patients with diabetes, heart failure, or CKD and found a 9% reduction in MACE and a 14% reduction in cardiovascular death with SGLT2 inhibitors versus placebo.
The analysis showed a remarkably consistent effect across all three patient groups, as well as key subgroups (established ASCVD, prior myocardial infarction, diabetes, prior heart failure, and different levels of kidney function). The reduction in MACE was driven by a reduction in cardiovascular death, specifically heart failure death and sudden cardiac death. There were no significant effects on myocardial infarction or stroke.
Dr. Brendon Neuen said, "By looking at the totality of the worldwide data from all large-scale, placebo-controlled outcome trials of SGLT2 inhibitors, we observed a conclusive reduction in cardiovascular death among patients with a broad range of clinical characteristics."
Diabetes is a known risk factor for cardiovascular and kidney disease, with impaired glucose control causing damage to blood vessels in the heart and kidneys. Many patients with diabetes live with ASCVD, CKD, or heart failure, with prevalence increasing in the years following a diabetes diagnosis.
Dr. Neuen added, "Despite the various benefits of SGLT2 inhibitors on cardiovascular-kidney-metabolic diseases, this class of medicine remains under-prescribed."
(Excerpt) Read more at medicalxpress.com ...
I assume losing weight on your own could help similarly, though.
There is some risk. SGLT2 has also been associated with major adverse events, including diabetic ketoacidosis in type 1 diabetes patients and limb amputations and genital and urinary tract infections in type 2 diabetes patients. The use in type 2 diabetes patients with cardiovascular disease, renal disease, or heart failure has been established in several large trials. Of concern are the increased risks of lower-limb amputation and bone fracture, diabetic ketoacidosis, acute kidney injury (AKI), serious urinary tract infections, and—more recently—Fournier gangrene (necrotizing fasciitis of the perineum). This study was done in 2018/19 by:
Ryan J. Sangiovanni, PharmD
Assistant Professor of Pharmacy Practice
Presbyterian College School of Pharmacy
Clinton, South Carolina
Carley E. DeVee, PharmD, BCPS
Assistant Professor of Pharmacy Practice
Presbyterian College School of Pharmacy
Clinton, South Carolina
So in a perfect world there are inperfections.
wy69
One dose of Jardiance made my brain go crazy.
Not taking another ever.
Did you ever try Farxiga?
I take one of these, and it reduces glucose ;evels, reduces insulin dose and gradually allows one tio lose weight.
I take Dapagliflozin. No side effects after one month, dropped about 10 pounds.
I recommend it for anyone with type II diabetes with A1C readings over 7.5 ( 139 ).
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I’ve read reviews from users on these type of drugs, like Jardiance, et al. There can be some serious side effects. Be cautious.
Start with krill oil and lots of distilled water every day first, you might be amazed at the results.
I’ve been on Synjardy XR (Jardiance and networking combo) for years. Recovering from a STEMI that happened Sunday.
I’ve been on Jardiance for 6+yrs, along w/ Glipizide. No problems at all, so far.
I have taken Jardiance with good results. Of course, losing weight would be great, as another poster says.
But so would be not procrastinating, running yellow lights, or any number of things you also have control over.
I am lucky...I have been taking a cocktail of drugs for a number of years to keep off insulin, and they have worked pretty well. As I get older, my weight is dropping too.
Today, my weight is down to 181 lbs, which is below what I weighed as an E2 in the US Navy back in 1976. It is partially due to loss of muscle mass, surely, but still a milestone for me. My goal for the last 10 years has been to get to 180...I may finally get there.
Perhaps not the way I wanted, but...I may get there.
Sounds good. What saves me is cutting 5 cord of firewood off myh wood lot every year, bucking it, spitting ot and throwing it into our basement and ranking it.
I am slow but steady, LOL.
LOL, I wish I had a mechanical option like that, not much yield on my quarter acre!
Hey, if you bring your chain saw , you can visit anytime, LOL.I’ll throw in a few moose stakes.
I took Jardiance for a short time - didn’t help glucose any more than a good diet.
Heh, you’re ON FRiend!
Egad. I hope all is well. You have my prayers for a full and swift recovery.
Having issues getting my Trijardy (metformin, Jardiance, Trajenta combo) refilled this week, looks like we’re competing with the dieters now.
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