Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Timid Mice Made Daring by Removing One Gene (most active in the brain's amygdala)
NY Times ^ | November 18, 2005 | BENEDICT CAREY

Posted on 11/17/2005 8:46:23 PM PST by neverdem

Scientists working with mice have found that by removing a single gene they can turn normally cautious animals into daring ones, mice that are more willing to explore unknown territory and less intimidated by sights and sounds that they have learned can be dangerous.

The surprising discovery, being reported today in the journal Cell, opens a new window on how fear works in the brain, experts said.

Gene therapy to create daredevil warriors is likely to remain the province of screenwriters, but the new findings may help researchers design novel drugs to treat a wide array of conditions, from disabling anxiety in social settings to the sudden flights of poisoned memory that can persist in the wake of a disaster, an attack or the horror of combat.

The discovery may well prove applicable to humans, the experts said, because the brain system that registers fear is similar in all mammals. Moreover, the genetic change did not appear to affect the animals' development in other ways.

"Potential clinical applications could be quite important" for people with "fear-related mental disorders," said Dr. Gleb Shumyatsky, an assistant professor of genetics at Rutgers, who led a team that included investigators from Columbia, Harvard, the Howard Hughes Medical Institute and the Albert Einstein College of Medicine.

Brain scientists who were not involved in the study said the study's finding was unexpected.

"The way I see it, there are three types of studies in science: one that moves a theory along, one that closes it and another that opens a new door altogether," said Dr. Thomas Insel, director of the National Institute of Mental Health, which helped finance the research. "This one opens a new chapter, introducing an entirely new molecular candidate for the study of anxiety, and we're going to be hearing a lot about..."

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Extended News; Government; News/Current Events; US: District of Columbia; US: Massachusetts; US: New York
KEYWORDS: amygdala; crevolist; stathmin
Navigation: use the links below to view more comments.
first 1-2021-36 next last

1 posted on 11/17/2005 8:46:24 PM PST by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

They would have to remove a million genes to keep Clinton from lying.


2 posted on 11/17/2005 8:48:31 PM PST by doug from upland ("Susan Estrich...get off your kneepads" - Juanita Broaddrick)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

social anxiety disorder ping


3 posted on 11/17/2005 8:49:22 PM PST by msf92497 (Uh Oh)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
interesting article, but I'm too scared to discuss it....

;-)

4 posted on 11/17/2005 8:49:36 PM PST by longshadow
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

I knew some college coeds who became daring upon the removal on one jean...


5 posted on 11/17/2005 8:50:45 PM PST by XEHRpa
[ Post Reply | Private Reply | To 1 | View Replies]

To: longshadow

Essentially, the mice will drop their genes and moon you.And that's no good.


6 posted on 11/17/2005 8:51:24 PM PST by BipolarBob (Yes I backed over the vampire, but I swear I looked in my rearview mirror.)
[ Post Reply | Private Reply | To 4 | View Replies]

To: neverdem
The Food You Eat May Change Your Genes For Life
7 posted on 11/17/2005 8:51:43 PM PST by blam
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Maybe we could use this discovery on demoncraps and wussy RINOs?


8 posted on 11/17/2005 8:52:12 PM PST by clee1 (We use 43 muscles to frown, 17 to smile, and 2 to pull a trigger. I'm lazy and I'm tired of smiling.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Thankfully this was discovered AFTER that meth lab in South Boston was found.


9 posted on 11/17/2005 9:01:15 PM PST by VeniVidiVici (What? Me worry?)
[ Post Reply | Private Reply | To 1 | View Replies]

To: El Gato; JudyB1938; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; ..
AIDS may help spread of bird flu

The Assembly of Protocells

FReepmail me if you want on or off my health and science ping list.

10 posted on 11/17/2005 9:13:04 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: VeniVidiVici

When this gene is removed from a U.S. Senator the become Republicans. Only way to spalin it


11 posted on 11/17/2005 9:15:26 PM PST by bybybill (GOD help us if the Rats win)
[ Post Reply | Private Reply | To 9 | View Replies]

To: blam

Thanks for the link.


12 posted on 11/17/2005 9:15:31 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 7 | View Replies]

To: neverdem

Shrews?


13 posted on 11/17/2005 9:21:26 PM PST by BIGLOOK (I once opposed keelhauling but recently have come to my senses.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: longshadow

I'm too scared to discuss it....

Uugh, don't tell anyone else, but I've heard rumors about substances that have the same, albeit temporary affect. But don't tell anyone I told you about it. BTW, I've heard rumors these substances may also 'enhance otherwise normal paranoia'..

14 posted on 11/17/2005 9:24:41 PM PST by ml1954 (NOT the disruptive troll seen frequently on CREVO threads)
[ Post Reply | Private Reply | To 4 | View Replies]

To: clee1

You beat me to it.


15 posted on 11/17/2005 9:33:09 PM PST by U S Army EOD (I NEED TO COME UP WITH ANOTHER TAG LINE)
[ Post Reply | Private Reply | To 8 | View Replies]

To: blam

I've noticed that from drinking.


16 posted on 11/17/2005 9:34:01 PM PST by U S Army EOD (I NEED TO COME UP WITH ANOTHER TAG LINE)
[ Post Reply | Private Reply | To 7 | View Replies]

To: neverdem

"... can turn normally cautious animals into daring ones, mice that are more willing to explore unknown territory and less intimidated ..."


Hmmmm?? I wonder how many of those genes we could have removed in the House and Senate.

WE NEED MORE DARING AND COURAGEOUS PEOPLE .. PEOPLE WHO ARE LESS INTIMIDATED BY THE LYING DEMOCRATS.


17 posted on 11/17/2005 9:59:38 PM PST by CyberAnt ( I believe Congressman Curt Weldon re Able Danger)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

If you take out the genes...are the shorts next?


18 posted on 11/17/2005 10:49:47 PM PST by WestVirginiaRebel (The Democratic Party-Jackass symbol, jackass leaders, jackass supporters.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: WestVirginiaRebel
If you take out the genes...are the shorts next?

lol

19 posted on 11/18/2005 6:25:15 PM PST by phantomworker (A new day! Begin it serenely; with too high a spirit to be encumbered with your old nonsense!)
[ Post Reply | Private Reply | To 18 | View Replies]

To: U S Army EOD

lol


20 posted on 11/18/2005 6:25:57 PM PST by phantomworker (A new day! Begin it serenely; with too high a spirit to be encumbered with your old nonsense!)
[ Post Reply | Private Reply | To 16 | View Replies]


Navigation: use the links below to view more comments.
first 1-2021-36 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson