I don’t think you can rely on pressure cooking alone to eliminate the threat from prions. Typically it needs to be combined with some extremely harsh phenol/chlorine/etc.
“20,000 ppm (2% sodium hypochlorite) available chlorine for 1 hour with sodium hypochorite as the chlorine releasing agent.”
“autoclave at 121°C for 30 minutes in sodium hydroxide.”
“The most effective chemical treatment for decontaminating formalin-fixed tissue is 96% formic acid for 1 hour.”
N.B.: Once infected, death is typically within six months.
Yes, my recollection was that there had been a demonstration that CJD prions were still active after being heated to 600°C. However, I could not find that reference by a quick Google search.