Posted on 09/14/2023 12:19:50 PM PDT by EBH
Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed a novel vaccine that, in laboratory tests, can completely reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and Crohn’s disease — all without shutting down the rest of the immune system.
A typical vaccine teaches the human immune system to recognize a virus or bacteria as an enemy that should be attacked. The new “inverse vaccine” does just the opposite: it removes the immune system’s memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, rheumatoid arthritis, or Crohn’s disease, in which the immune system attacks a person’s healthy tissues.
The inverse vaccine, described in a recent paper published in Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reactions to cells that die by natural processes. PME researchers coupled an antigen — a molecule being attacked by the immune system— with a molecule resembling a fragment of an aged cell that the liver would recognize as friend, rather than foe. The team showed how the vaccine could successfully stop the autoimmune reaction associated with a multiple-sclerosis-like disease.
“In the past, we showed that we could use this approach to prevent autoimmunity,” said Jeffrey Hubbell, the Eugene Bell Professor in Tissue Engineering and lead author of the new paper. “But what is so exciting about this work is that we have shown that we can treat diseases like multiple sclerosis after there is already ongoing inflammation, which is more useful in a real-world context.”
Unwinding an immune response The job of the immune system’s T cells is to recognize unwanted cells and molecules — from viruses and bacteria to cancers — as foreign to the body and get rid of them. Once T cells launch an initial attack against an antigen, they retain a memory of the invader to eliminate it more quickly in the future.
T cells can make mistakes, however, and recognize healthy cells as foreign. In people with Crohn’s disease, for instance, the immune system attacks cells of the small intestine; in those with multiple sclerosis, T cells mount an attack against myelin, the protective coating around nerves.
Hubbell and his colleagues knew that the body has a mechanism for ensuring that immune reactions don’t occur in response to every damaged cell in the body— a phenomenon known as peripheral immune tolerance and carried out in the liver. They discovered in recent years that tagging molecules with a sugar known as N-acetylgalactosamine (pGal) could mimic this process, sending the molecules to the liver where tolerance to them develops.
“The idea is that we can attach any molecule we want to pGal and it will teach the immune system to tolerate it,” explained Hubbell. “Rather than rev up immunity as with a vaccine, we can tamp it down in a very specific way with an inverse vaccine.”
In the new study, the researchers focused on a multiple-sclerosis-like disease in which the immune system attacks myelin, leading to weakness and numbness, loss of vision and, eventually mobility problems and paralysis. The team linked myelin proteins to pGal and tested the effect of the new inverse vaccine. The immune system, they found, stopped attacking myelin, allowing nerves to function correctly again and reversing symptoms of disease in animals.
n a series of other experiments, the scientists showed that the same approach worked to minimize other ongoing immune reactions.
Toward clinical trials Today, autoimmune diseases are generally treated with drugs that broadly shut down the immune system.
“These treatments can be very effective, but you’re also blocking the immune responses necessary to fight off infections and so there are a lot of side effects,” said Hubbell. “If we could treat patients with an inverse vaccine instead, it could be much more specific and lead to fewer side effects.”
More work is needed to study Hubbell’s pGal compounds in humans, but initial phase I safety trials have already been carried out in people with celiac disease, an autoimmune disease that is associated with eating wheat, barley, and rye, and phase I safety trials are underway in multiple sclerosis. Those trials are conducted by the pharmaceutical company Anokion SA, which helped fund the new work and which Hubbell cofounded and is a consultant, board member, and equity holder. The Alper Family Foundation also helped fund the research.
“There are no clinically approved inverse vaccines yet, but we’re incredibly excited about moving this technology forward,” says Hubbell.
Reference: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses” by Andrew C. Tremain, Rachel P. Wallace, Kristen M. Lorentz, Thomas B. Thornley, Jennifer T. Antane, Michal R. Raczy, Joseph W. Reda, Aaron T. Alpar, Anna J. Slezak, Elyse A. Watkins, Chitavi D. Maulloo, Erica Budina, Ani Solanki, Mindy Nguyen, David J. Bischoff, Jamie L. Harrington, Rabinarayan Mishra, Gregory P. Conley, Romain Marlin, Nathalie Dereuddre-Bosquet, Anne-Sophie Gallouët, Roger LeGrand, D. Scott Wilson, Stephan Kontos and Jeffrey A. Hubbell, 7 September 2023, Nature Biomedical Engineering. DOI: 10.1038/s41551-023-01086-2
No “laboratory tests” prove any such thing.
This was the story two days ago:
CDC data shows COVID-19 vaccines can decrease the life expectancy of men by 24 YEARS.
Inverse Vaccine, sounds like One Hell of a Bio-Weapon. Make people’s immune system “forget” how to protect the body.
WHAT could possibly go wrong ??????
It’s so good it will make a blind man hear and a deaf man see.
so essentially the readers digest version states, this vaccine will cure the illnesses that the previous vaccines caused.
Yeah, sign me up.
NOT!!!
Did no one see the movie “I am legend”
The implication of this is HUGE. Being able to selectively delete items from immune memory means potentially all autoimmune disorders can be cured.
It's smart, but because companies aren't liable for any injuries vaccines cause. If they call all medication vaccines from now on, they will save trillions on vaccines.
Yes! and a few drops on a Mcdonalds filet of fish and you canfeed a family of 35 with the finest Chilean Bass...
Bump
Wonder if tried this on Giant Cell Arteritis?
Like polio, Spanish flu, MERS, SARS and all kinds of potentially fatal viruses. China is going to love this when they get hold of it.
It is...if you can get past the doubters...LOL
I sure hope they figure these things out
rheumatoid inflammation is no joke - and I speak from experience. The drugs today have come along way in preventing joint damage, but your life is still shortened, and your quality of life is severely harmed.
“New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease”
Islets of Langerhan have already been destroyed in Type 1 diabetes ... NO vaccine can re-establish them ... period ...
Pritzker as any relation to the Illinois Governor.
Or it could kill you within a year. Roll the dice.
This is what zero credibility looks like.
In other words, yet again the pharmaceutical industry has
a “solution” for medical problems it created.
Going to be almost impossible to trust any new thing after the covid bio weapon vaxx
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