Hundreds of thousands of lives have been saved over the years when naloxone — commonly known as Narcan — is administered to someone overdosing on opioids. Drugs Illegal drugs such as cocaine, heroin, and fentanyl can be mixed with xylazine, either to enhance drug effects or increase street value by increasing their weight. sedative/tranquilizer called xylazine to heroin, fentanyl and other opioids. And that’s bad news for addicts because naloxone doesn’t reverse a xylazine overdose. National Center for Biotechnology Information “You overdose on xylazine, and you’re going to die,” said the commander of the Greater Harrison Drug & Violent Crimes...