Posted on 09/30/2021 1:13:38 PM PDT by nickcarraway
A likely cause of Alzheimer’s disease offers a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.
Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer’s disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.
The study, published in the prestigious PLOS Biology journal and tested on mouse models, identified that a probable cause of Alzheimer’s disease was the leakage from blood into the brain of fat-carrying particles transporting toxic proteins.
Lead investigator Curtin Health Innovation Research Institute (CHIRI) Director Professor John Mamo said his collaborative group of Australian scientists had identified the probable ‘blood-to-brain pathway’ that can lead to Alzheimer’s disease, the most prevalent form of dementia globally.
“While we previously knew that the hallmark feature of people living with Alzheimer’s disease was the progressive accumulation of toxic protein deposits within the brain called beta-amyloid, researchers did not know where the amyloid originated from, or why it deposited in the brain,” Professor Mamo said.
“Our research shows that these toxic protein deposits that form in the brains of people living with Alzheimer’s disease most likely leak into the brain from fat carrying particles in blood, called lipoproteins.
“This ‘blood-to-brain pathway’ is significant because if we can manage the levels in blood of lipoprotein-amyloid and prevent their leakage into the brain, this opens up potential new treatments to prevent Alzheimer’s disease and slow memory loss.”
Building on previous award-winning research that showed beta-amyloid is made outside the brain with lipoproteins, Professor Mamo’s team tested the ground-breaking ‘blood-to-brain pathway’ by genetically engineering mouse models to produce human amyloid-only liver that make lipoproteins.
“As we predicted, the study found that mouse models producing lipoprotein-amyloid in the liver suffered inflammation in the brain, accelerated brain cell death, and memory loss,” Professor Mamo said.
“While further studies are now needed, this finding shows the abundance of these toxic protein deposits in the blood could potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid, therefore reducing their risk or slowing the progression of Alzheimer’s disease.”
Alzheimer’s WA Chairman Adjunct Professor Warren Harding said the findings may have a significant global impact for the millions of people living with Alzheimer’s disease.
“Having universities like Curtin working with the pharmaceutical industry is important if we are to tackle this devastating disease,” Mr. Harding said.
“In Australia, approximately 250 people are diagnosed with dementia daily, adding to the staggering half a million Australians who are already living with dementia. Without significant medical advances like the breakthrough Professor Mamo’s team has made, it is estimated that the number of Australians living with dementia will exceed one million by 2058. This has a significant impact on families, carers and communities.”
Professor Mamo and his research team’s previous research in this area was awarded the NHMRC-Marshall and Warren Award for the most innovative and potentially transformative research.
Currently, the team is conducting a clinical trial, the Probucol in Alzheimer’s-clinical trial, which is based on previous findings that a historic cardiovascular agent lowers lipoprotein-amyloid production and supports cognitive performance in mice.
For more on this research, see Protein Made in the Liver May Cause Alzheimer’s Disease in the Brain.
Reference: “Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype” by Virginie Lam, Ryusuke Takechi, Mark J. Hackett, Roslyn Francis, Michael Bynevelt, Liesl M. Celliers, Michael Nesbit, Somayra Mamsa, Frank Arfuso, Sukanya Das, Frank Koentgen, Maree Hagan, Lincoln Codd, Kirsty Richardson, Brenton O’Mara, Rainer K. Scharli, Laurence Morandeau, Jonathan Gauntlett, Christopher Leatherday, Jan Boucek, John C. L. Mamo, 14 September 2021, PLOS Biology. DOI: 10.1371/journal.pbio.3001358
They need to look at the researcher that found bacteria in the plaques.
Then read the Scientific American article this year that detailed an experiment twenty years ago that found stress compromised the blood brain barrier in mice.
Statins affect the fat levels in the blood.
Wondering if long term statin use has positive results against AZ.
This has to be at least the 10th (in as many years) “breakthrough” for the treatment of Alzheimer’s that I’ve seen, never to be heard of again.
I add chocolate. High in antioxidants. ;-)
I believe you. Pizza actually doesn’t contain anything really bad (not really really I mean). It’s got all 5 food groups and no pesky grown or artificial sugars.
Its only ground breaking if Uncle steve is hooked up to a drool cup on Monday and perfectly fine on Friday.
Eat more fish. (See tagline)
He also weighs 300 pounds.
Perfect Pizza is like quantum mechanics. If you think you know what it is, you don’t know what it is.
Real Sicilian pizza doesn’t use yeast but a starter from old dough.
And yes, it’s da bomb.
Fat is essential to the brain. Without it the brain goes dull.
A misleading article for sure.
Bkmk
Well, since his wife died, he’s joined a couple of these cooking clubs/shows, and this is a variant of a recipe he got. He always sends me pics of his masterwork as soon as it’s done, and it looks delicious. I’m overdue to go visit his new home in WV, so I think it may be time to go gorge, drink beer, and shoot guns. Not necessarily in that order. Damn shame he sold his boat.
I specifically remember…
Off Taormina, outside, scraping toppings off the crust…
All those centuries of stuff under the fields. That TASTE!,,,
Have fun,Viking2002
Mmmmmm, organic and a nice mineral finish, eh?
I'd stick with the pizza and beer, and drop the ice cream. Apparently that's what Biden eats all the time, and it's not done his senility any good.
How’s it do on stains?
And yet Vitamn D poisoning is virtually non-existent despite people taking these levels.
And yet Vitamn D poisoning is virtually non-existent despite people taking these levels.
I think it causes problems that people don’t know are caused by excess vitamin D.
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