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Cannabis-based drugs might relieve bowel disease
Yahoo ^

Posted on 08/13/2005 12:00:36 PM PDT by traumer

NEW YORK (Reuters Health) - Derivatives of the active compound in cannabis -- cannabinoids -- may have the potential for treating inflammatory bowel diseases like Crohn's disease and ulcerative colitis, UK researchers report.

"The system that responds to cannabis in the brain is present and functioning in the lining of the gut," lead researcher Dr. Karen Wright, of the University of Bath, explained to Reuters Health. "There is an increased presence of one component of this system during inflammatory bowel diseases," she explained.

Wright and her colleagues established the location of cannabinoid receptors CB1 and CB2 in human colon tissue, and used human colon cell lines to investigate the binding of cannabinoid compounds and in wound-healing experiments. They report their findings in the journal Gastroenterology

The team found that CB2 was increased in colonic tissue characteristic of inflammatory bowel disease. Cannabinoids enhanced surface wound closure via CB1-related mechanisms.

"Cannabinoids, which we make ourselves, as well as synthetic cannabinoids, can promote wound healing in the gut, which is extremely interesting given that inflammatory bowel disease involves damaged gut linings," Wright said.

Although results are available yet, she added, relevant studies of the use of cannabinoids are taking place in the UK and a clinical trial is being conducted in Germany.


TOPICS: Heated Discussion
KEYWORDS: health; medicine; thatsmrleroytoyou; wodlist
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1 posted on 08/13/2005 12:00:36 PM PDT by traumer
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To: traumer

Does this require ingesting the stuff? Sounds foul...


2 posted on 08/13/2005 12:02:04 PM PDT by coconutt2000 (NO MORE PEACE FOR OIL!!! DOWN WITH TYRANTS, TERRORISTS, AND TIMIDCRATS!!!! (3-T's For World Peace))
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To: traumer

BUll!

Anything to promote dope and more dopes.


3 posted on 08/13/2005 12:02:19 PM PDT by nmh (Intelligent people recognize Intelligent Design (God).)
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To: coconutt2000

cannibis colonic cocktail?


4 posted on 08/13/2005 12:02:56 PM PDT by al baby (Father of the beeber)
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To: traumer

"Wow! That's some good s%$#, man!"


5 posted on 08/13/2005 12:04:20 PM PDT by JennysCool (Non-Y2K-Compliant)
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To: traumer
Marijuana! The wonder drug!!!

Sarcasm/off

6 posted on 08/13/2005 12:04:29 PM PDT by FlingWingFlyer (We did not lose in Vietnam. We left.)
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To: JennysCool

LOL


7 posted on 08/13/2005 12:04:54 PM PDT by Stellar Dendrite (The presence of "peace" is the absence of opposition to socialism -- Marx)
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To: traumer
Would the new slogan be "Got hemorrhoids? Try cannabinoids!" ???
8 posted on 08/13/2005 12:05:01 PM PDT by NonValueAdded ("Freedom of speech makes it much easier to spot the idiots." [Jay Lessig, 2/7/2005])
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To: traumer

Hmmmm.... Legalizing marijuana might solve our health care problems?

Well, it would be better than socialized medicine.


9 posted on 08/13/2005 12:06:12 PM PDT by Brilliant
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To: nmh

Yeah, but don't tell the Liberal Christian Fundamentalists in this country that want more government intrusion into our personal lives.


10 posted on 08/13/2005 12:08:13 PM PDT by lightislife
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To: nmh

"Anything to promote dope and more dopes."

So, even if the medical research bears the claim out, you'll dismiss it as some sort of covert propaganda?

The bizarre hatred some people have of pot confuses me.

I don't know what the testing will show, and I'm skeptical until they can produce some sort of data, but I don't dismiss anything out of hand.


11 posted on 08/13/2005 12:09:11 PM PDT by highball ("I find that the harder I work, the more luck I seem to have." -- Thomas Jefferson)
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To: traumer

Time to change the old recipe from brownies to bran muffins...


12 posted on 08/13/2005 12:10:26 PM PDT by mikrofon (High colonic?)
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To: highball

The problem is that LEGITIMTE medical research does NOT bear this out ... as I said, anything to promote dope and more dopes.


13 posted on 08/13/2005 12:10:33 PM PDT by nmh (Intelligent people recognize Intelligent Design (God).)
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To: traumer

Any excuse.

With every disease that comes down the turnpike, someone claims a joint is the cure all.


14 posted on 08/13/2005 12:11:44 PM PDT by mtbopfuyn (Legality does not dictate morality... Lavin)
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To: traumer

So legalize a dangerous drug to treat something that can already be taken care of with existing medications? No thanks. Plus there's an element of class warfare here. Replacing commercial drugs that pharmaceutical companies worked hard to develop, with something that's cheap and unpatented.


15 posted on 08/13/2005 12:12:45 PM PDT by balch3
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To: nmh
as I said, anything to promote dope and more dopes.

I think you have been asked -- so what? Can you imagine the effect if they were to declare the WOD over? Overnight, the cartels would collapse, crime would reduce at least 50%, and no one's life would be any the worse.

Arresting someone for smoking a little doob' in the privacy of their own home has got to be the worst possible use of public funds.

16 posted on 08/13/2005 12:14:20 PM PDT by freedumb2003 (Durka Durka Durka. Muhammed Jihad Durka.)
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To: lightislife
"Yeah, but don't tell the Liberal Christian Fundamentalists in this country that want more government intrusion into our personal lives."

This thread is about promoting dope again based on shoddy medical research.


YAAAWWWWNNNN Don't try the bait and switch crap with me - from promoting dope to Liberals. A fundamentalist doesn't want government in their lives so if you're trying to change the subject be consistent - LIBERALS of any stripe want dope legalized because they are dopes too.
17 posted on 08/13/2005 12:14:43 PM PDT by nmh (Intelligent people recognize Intelligent Design (God).)
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To: traumer

This requires it to be administrated by a rectal enema of course?!


18 posted on 08/13/2005 12:14:45 PM PDT by 26lemoncharlie ('Cuntas haereses tu sola interemisti in universo mundo!')
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To: nmh
LIBERALS of any stripe want dope legalized because they are dopes too.

I guess that explains all of the freepers in favor of eliminating the War On (some) Drugs.

They must all be evil LIBERALS!

Maybe you should look at the history of why pot was criminalized in the first place.

19 posted on 08/13/2005 12:18:57 PM PDT by ActionNewsBill ("In times of universal deceit, telling the truth is a revolutionary act")
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To: al baby
cannibis colonic cocktail?

Ahhh yes, the fabled high colonic. This might be a wonderful adjunct to the fabled coffee enema.

20 posted on 08/13/2005 12:19:24 PM PDT by Pearls Before Swine
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To: nmh

Do you have proof that the research will not bear it out for this application? The article seems to indicate that the research is not yet complete.

Or are you generalizing based on previous, unrelated studies for different applications?


21 posted on 08/13/2005 12:23:40 PM PDT by highball ("I find that the harder I work, the more luck I seem to have." -- Thomas Jefferson)
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To: ActionNewsBill
Or ask them why the federal government needed a constitutional amendment to ban alcohol, but need no such amendments to ban pot.

The WOD is a state's rights issue. Get the feds out of it. If states want to wage their own drug wars, let them.

Letting the government take power it shouldn't have because you like to make fun of "stoners and potheads" is worse than any stoner or pothead out there. You're enabling the wholesale abuse of the constitution...and then you moan when they piss on the constitution when it comes taking YOUR constitutional rights.
22 posted on 08/13/2005 12:26:17 PM PDT by flashbunny (Always remember to bring a towel!)
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To: balch3
"Plus there's an element of class warfare here. Replacing commercial drugs that pharmaceutical companies worked hard to develop, with something that's cheap and unpatented."

Are you trying to say that if someone finds a cheap inexpensive unpatented cure for a disease it shouldn't be allowed because it would discriminate against the rich pharmaceutical companies ?
23 posted on 08/13/2005 12:26:56 PM PDT by grjr21
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To: traumer

My next door neighbor and his 5 yr old son both have severe
Crohns..

If this stuff were to aid in their suffering I am all for it
inspite of being a fundamentalist Christian

Once upon a time medical doctors swore and oath to 'first do no harm' to their patients this includes denying them pain relief that our asinie war on drugs has precluded them often from being able to do..

Meanwhile illegal alien drug mules who also do farm and food processing are making sure that rural midwestern school kids
are introduced to the wonderful medicinal benefits of Mexican 'Red' Methamphetamine...

Thanks to the OBL...and BayouBush

imo


24 posted on 08/13/2005 12:30:44 PM PDT by joesnuffy (Save the whales. Redeem them for valuable prizes.)
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To: nmh
'Good' bacteria helps ease pain of colitis

A mixture of bacteria developed in part by University of Alberta researchers has been proven highly effective in treating people suffering from ulcerative colitis.

The findings, published in the July, 2005 issue of American Journal of Gastroenterology showed that the majority of patients taking a probiotic mixture of 8 bacteria (VSL#3) for 6 weeks improved their ulcerative colitis. Probiotics are preparations of living microbial cells that, when ingested, are thought to positively influence the composition of microbes in the gut and improve the health of the intestine.

While "bad" bacteria have been flagged as potential culprits in the cause of inflammatory diseases of the bowel, in this case, the ingestion of supplemental "good" bacteria (probiotics) to the intestine proved beneficial in treating ulcerative colitis, said Dr. Richard Fedorak, a professor of gastroenterology at the University of Alberta. The joint study included researchers from the University of Bologna in Italy and the University of North Carolina.

In this open label clinical trial, 86 per cent of those treated with probiotic bacteria mixture VSL#3 experienced relief of their mild to moderate ulcerative colitis. The mixture of eight lactic acid bacterial species is believed to be effective by mechanisms that include (1) reducing the number of "bad" bacteria, (2) reducing the amount of inflammation (3) increasing the mucus layer in the gut, and (4) increasing the amount of anti-inflammatory molecules in the intestine.

Ulcerative colitis is an inflammatory bowel disease that affects the large intestine (colon) and causes acute bloody diarrhea, sever stomach pain, urgency, anemia and fatigue. In its most severe form, ulcerative colitis that does not respond to medical treatment will require surgical removal of the colon.

The VSL#3 was administered over a six-week period to 30 patients who ranged in age from 18 to 65. Remission of the colitis was achieved in 63 per cent of the patients, while another 23 per cent responded with improvement in their symptoms and with healing of the colon's lining. There were no adverse effects to the medication.

The VSL#3 can be considered an important potential treatment for those patients who don't respond to conventional therapy such as mesalamine or 5ASA, Dr. Fedorak said.

###

For more information on this study, contact:

Bev Betkowski Media Relations Officer University of Alberta 780-492-3808 beverly.betkowski@ualberta.ca

25 posted on 08/13/2005 12:36:57 PM PDT by Moonman62 (Federal creed: If it moves tax it. If it keeps moving regulate it. If it stops moving subsidize it)
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To: grjr21

They should be allowed to make a fair profit. Is there something wrong with "rich companies?" Why are you bashing them? What's next, a rant against the oil companies for making "too much money?"


26 posted on 08/13/2005 12:38:50 PM PDT by balch3
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To: traumer
Cigarettes have the same affect.
27 posted on 08/13/2005 12:45:46 PM PDT by dila813
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To: traumer
"Hey, man. How's your intestinal tract, man?"

"Healthy, man!"


28 posted on 08/13/2005 12:48:43 PM PDT by governsleastgovernsbest (check out my posts on Today Show bias at www.newsbusters.org)
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To: balch3
Making a fair even great profit is one thing,
but from your post you seemed to suggest that since they worked hard for it if anything threatened that profit it should be made illegal
29 posted on 08/13/2005 12:49:46 PM PDT by grjr21
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To: mikrofon
Time to change the old recipe from brownies to bran muffins...

no, no, no, think texture

corn bread!!

30 posted on 08/13/2005 12:50:08 PM PDT by KosmicKitty (Well... There you go again!)
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To: nmh
"Yeah, but don't tell the Liberal Christian Fundamentalists in this country that want more government intrusion into our personal lives."

Drug warriors are the right wings answer to gun banners. The great H.L. Mencken labeled them "wowsers," that is, people who bear a divine commission to regulate and improve the rest of us. He described them along the lines of "people who cannot sleep at night knowing that somewhere in America, someone is having fun."

31 posted on 08/13/2005 12:50:33 PM PDT by atomic_dog
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To: traumer

Gives a whole new meaning to "Your a** sucks wind," don't it?


32 posted on 08/13/2005 12:55:48 PM PDT by Old Professer (As darkness is the absence of light, evil is the absence of good; innocence is blind.)
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To: joesnuffy

There is research and genuine testing going on now regarding the use of pigworm larve in the treatment of IBD. I have a relative that is afflicted and they have been looking into the subject. The early numbers are positive. She is hoping the treatment gets approval. Old story from WebMD:

http://my.webmd.com/content/Article/74/89187.htm?pagenumber=1

Parasitic Worms Ease IBD

May Reduce Overactive Immune Response Behind Crohn's Disease, Ulcerative Colitis


33 posted on 08/13/2005 12:56:36 PM PDT by ChildOfThe60s (If you can remember the 60s......you weren't really there.)
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To: highball

Do you have any proof that you won't self-destruct in the next thirty seconds?


34 posted on 08/13/2005 12:56:58 PM PDT by Old Professer (As darkness is the absence of light, evil is the absence of good; innocence is blind.)
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Comment #35 Removed by Moderator

To: atomic_dog
Drug warriors are the right wings answer to gun banners.

You might be surprised at the number of FReepers who are both.

36 posted on 08/13/2005 12:58:48 PM PDT by ActionNewsBill ("In times of universal deceit, telling the truth is a revolutionary act")
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To: ActionNewsBill
You might be surprised at the number of FReepers who are both.

No, not at all. What did surprise me greatly was the number of FReeeprs who are 100% behind the open border policy. That to me is inexplicable.

37 posted on 08/13/2005 1:01:06 PM PDT by atomic_dog
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To: traumer

A Crohn's patient died in trials of a new drug for Crohn's, Tysabri.

An MS patient died in trial of the same drug.

The drug was found to have the potential to cause a devastating neurological disease, PML.

They pump Crohn's patients full of steroids, and MS patients full of interferons, but heaven forbid that a little marijuana might work for these conditions.

I have MS, and what amazes me is that nobody seems too concerned with the "danger" involved in the interferon I "shoot up" every other day.

But let someone suggest that marijuana might help, and everybody starts talking about the side effects or how dangerous it might be, when in comparison to what is already prescribed for these conditions, marijuana has minimal side effects.


38 posted on 08/13/2005 1:01:56 PM PDT by dawn53
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To: al baby

yuck yuck yuck...

Sounds like a plot from a Three Stooges episode... Well, a hybrid three stooges and Snoop Doggie Dog...


39 posted on 08/13/2005 1:06:17 PM PDT by coconutt2000 (NO MORE PEACE FOR OIL!!! DOWN WITH TYRANTS, TERRORISTS, AND TIMIDCRATS!!!! (3-T's For World Peace))
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To: coconutt2000
>>>
I dont think that it is the marijuana that relieves the bowel disease, it is the bag-after-bag of Doritos that gives the fiber necessary to relieve the bowel disease.
40 posted on 08/13/2005 1:07:29 PM PDT by keithtoo (Howard Dean's Democratic Party: Traitors, Haters, and Vacillators)
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To: keithtoo

I once found wild MJ plants growing on a service driveway on our property once... I uprooted them and tossed them in the compost heap. The landscapers were later directed to clear away all the wild brush that was creeping over from our neighbors property, where I think the plants had originated.


41 posted on 08/13/2005 1:11:05 PM PDT by coconutt2000 (NO MORE PEACE FOR OIL!!! DOWN WITH TYRANTS, TERRORISTS, AND TIMIDCRATS!!!! (3-T's For World Peace))
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To: nmh
LIBERALS of any stripe want dope legalized because they are dopes too.

I'm a conservative, and I want it legalized. Criminalization of marijuana for adults is just a plain waste of energy and a restriction on freedom. Also, I think I'll have to give it try for treatment of my ulcerative colitis. ;-)

42 posted on 08/13/2005 1:17:27 PM PDT by glorgau
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To: nmh
Although results are available yet, she added, relevant studies of the use of cannabinoids are taking place in the UK and a clinical trial is being conducted in Germany.

This thread is about promoting dope again based on shoddy medical research.

Since it appears that the studies are not yet complete, it may be a bit reactionary to pronounce them shoddy.

The following is just my personal observation so take it for what it's worth.

Back in the 80's I was acquainted with a fellow who suffered from Crohns disease and who also was a regular pot smoker. He never once related that weed helped alleviate his suffering. He did mention that codeine based cough syrups were helpful. (He managed to get himself in trouble because of because of that fact.)

So I'm skeptical of the suggestion that smoking weed would have any efficacy here. But I'm not willing to dismiss out-of-hand that a chemical present in cannabis, correctly delivered, may be useful.

I'll wait until the studies are published and reviewed first.

43 posted on 08/13/2005 1:22:05 PM PDT by Freebird Forever (AMERICA FIRST !!!)
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To: coconutt2000
I once found wild MJ plants growing on a service driveway on our property once... I uprooted them and tossed them in the compost heap. The landscapers were later directed to clear away all the wild brush that was creeping over from our neighbors property, where I think the plants had originated.

Good thing you did, or else you might have been visited very soon by black-garbed gun-toting "public servants" who made their entrance by kicking in your front door at midnight. That is of course, after your assets were frozen and your car impounded.
44 posted on 08/13/2005 1:22:34 PM PDT by fr_freak
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To: freedumb2003

just ask that 22 yr old guy in Florida that was shot 10 times by the swat team when they busted into his home at 6:15 a.m. on a no knock warrant.

They scooped up 2 oz of pot!!!! big time dealer!!! There is a major uproar about it down there...a thread was here about it. I hope the 2 cops that shot him get about 12 yrs each...till their execution date and I hope the guys folks sue this police dept into complete bankruptcy and oblivion.


45 posted on 08/13/2005 1:29:55 PM PDT by cajun-jack
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To: traumer
Cannabis-based drugs might relieve bowel disease
Another Dippy-Hippy ruse to get a buzz-on!
46 posted on 08/13/2005 1:30:17 PM PDT by Minutemen ("It's a Religion of Peace")
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To: fr_freak

No need to worry about the Feds. They don't have a regular presence in the territory, and it was only a few plants that apparently sprouted from seeds that blew over the property border.

I went back and walked over the area after it was completely cleared and found no new growth. The stuff is a weed, literally. The cops have a bigger problem with the actual farms of the stuff that have apparently been cultivated up in the hills, hidden between taro plants.

Personally, I'm in favor of NOT legalizing the damned plant, even for medicinal use. The culture that has grown up around the plant is one that induces and invites abuse, and we have enough other problems to deal with as it is. Why add to it?

(And our neighbor is a prime example of someone who lives in a house that is falling apart around him, but will spend money on weed, rather than on repairs.)


47 posted on 08/13/2005 1:39:47 PM PDT by coconutt2000 (NO MORE PEACE FOR OIL!!! DOWN WITH TYRANTS, TERRORISTS, AND TIMIDCRATS!!!! (3-T's For World Peace))
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To: traumer
Sounds more like Alice B. Toklas brownies are the ticket ~ smoking wouldn't quite do it.

Leastwise not "normal" smoking~!

48 posted on 08/13/2005 1:40:19 PM PDT by muawiyah (/ hey coach do I gotta' put in that "/sarcasm " thing again?)
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To: highball
We got your number ~ you guys are all the time coming up with "new cures" from dope ~ and if any of them were true, most of you would be in the epitome of health rather than crouched down over there in the corner trying to shade your eyes from sunlight.

Odds are always very good that druggies lie.

49 posted on 08/13/2005 1:42:06 PM PDT by muawiyah (/ hey coach do I gotta' put in that "/sarcasm " thing again?)
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To: traumer

There's no way that that can help Crons disease nor IBS. Wouldn't do a thing for diverticulitis either.


50 posted on 08/13/2005 1:45:29 PM PDT by nopardons
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