Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis

Wiley-Liss ^ | 12,27.05 | Mokenge P. Malafa

[Coleus]

Cancer Cell Biology

Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis

Mokenge P. Malafa ^{1 *}, Frida D. Fokum ², Jennifer Andoh ², Leslie T. Neitzel ², Sucharita Bandyopadhyay ³, Rui Zhan ³, Megumi Iiizumi ³, Eiji Furuta ³, Elizabeth Horvath ¹, Kounosuke Watabe ³

¹Division of GI Tumors, Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Surgical Oncology Laboratory, Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL
³Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, IL

email: Mokenge P. Malafa (malafamp@moffitt.usf.edu)

^*Correspondence to Mokenge P. Malafa, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, SRB-1-21207, Tampa, FL 33612, USAFax: 813-745-8332

Funded by:
 US Army Medical Research, Department of Defense Breast Cancer Research Program; Grant Number: DAMD17-01-1-04
 William E. McElroy Charitable Foundation Research Grant

Keywords

vitamin E succinate • prevention • nutrition • cancer • proliferation • tumor growth

Abstract

Prostate cancer is a major cause of cancer death and morbidity in western countries. However, because of its intrinsic nature of chemoresistance, there is only limited systemic therapy available for the patients. Vitamin E (VE) has been under intensive study as a chemopreventive agent for various types of cancers. Preclinical studies suggest that vitamin E succinate (VES) is the most effective antitumor analogue of VE, yet there are scarce studies of VES in prostate cancer. In this study, we investigated the effects of VES on a panel of prostate cancer cells, and a xenograft model of prostate cancer. Our results indicate that VES significantly inhibited proliferation and induced apoptosis of prostate cancer cell lines in a dose and time dependent manner. The results of microarray analysis followed by real-time RT-PCR and inhibitor analyses indicated that the VES-induced apoptosis is mediated by caspase-4 in prostate tumor cells. In our animal model of prostate cancer in SCID mouse, daily injection of VES significantly suppressed tumor growth as well as lung metastases. These results suggest a potential therapeutic utility of VES for patients with prostate cancer. © 2005 Wiley-Liss, Inc.

[Archie Bunker on steroids]

Thats a record for words I don't understand in a title.

[Salamander]

I think apoptosis has something to do with these;

[al baby]

Yuo don't mean we have to insert pop tarts rectaley do you ?

[Global2010]

Studies have found a drawback in the therapeutic inducement may cause severe adverse reactions such as those found in para menopausal women ...
induced crying was the most pronounced especially in the arena of hunting and sport gaming when the smallest game was gathered..




ok it was not funny but I gave it my weakest sarcastic shot...

[Lurker]

Inserting them rectally is optional.

L

[Global2010]

In other words, eat well, walk around a whole lot and fellows gulp and let the Doc check your hiney.

Your wives will love you for it.

[Salamander]

I dunno but you wouldn't wanna toast them first, if it does....:)