Alzheimer's disease - a neurospirochetosis.

The Journal of NeuroInflamation ^ | August 4, 2011 | By Judith Miklossy, MD

[Swordmaker]

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

Judith Miklossy
Correspondence: Judith Miklossy judithmiklossy@bluewin.ch

Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90

Published: 4 August 2011
Abstract (provisional)

It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls. Periodontal pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum, T. medium, T. socranskii) and Borrelia burgdorferi were detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in AD. The pathological and biological hallmarks of AD were reproduced in vitro. The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Persisting inflammation and amyloid deposition initiated and sustained by chronic spirochetal infection form together with the various hypotheses suggested to play a role in the pathogenesis of AD a comprehensive entity. As suggested by Hill, once the probability of a causal relationship is established prompt action is needed. Support and attention should be given to this field of AD research. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

[grey_whiskers]

Makes ABSOLUTE SENSE.

Will read over the weekend.

Consider yourself *HIGHLY* commended.

Cheers!

[grey_whiskers]

*PING* (Possibly controversial but well worth reading.)

Thanks, Swordmaker.

[9YearLurker]

Wow, that’s some dental office you’ve got there! Thanks for the info.

[Swordmaker]

Listerine kills them.

Sorry, no. It doesn't. Trust me... we've been researching these bugs for five years. The doctor who's office I manage is one of the top impantologists in the world... and essential oils in Listerine just do not kill the spirochetes well enough to do the job. We wish it did.

[Gadsden1st]

I rinse my mouth daily with colloidal silver solution. Should do the trick! And NO, I am not turning blue.

[momtothree]

Sorry, Swordmaker, another question popped in my mind. Can children use the clorox with water as a rinse as well? My youngest is 5... can she use it as well?

[drjulie]

It makes sense that baking soda would scratch veneers. My mom has alzheimer’s and type 2 diabetes. It really motivates me to keep up with the research. Interestingly, she was diagnosed with both of these diseases at the same time.

[old and tired]

Very interesting. I had an old aunt whose husband died of a massive heart attack. A couple of months prior he was experiencing pain in his chest. The old country doc said he needed to extract all my uncle's teeth immediately. My aunt begged her husband not to have his teeth pulled. She blamed herself for his heart attack until the day she died.

I always thought it was the ramblings of a crazy old lady...

[dangerdoc]

I was told that H2O2 would weaken enamel. What would laundry bleach do?

[Hot Tabasco]

I’ve always liked baking soda as a toothpaste but my dentist discouraged it as it is a bit abrasive.

Interesting because I had been brushing with Baking S prior to my last dental visit and told my hygienist of that fact and she applauded me.......

[Hot Tabasco]

I can’t use baking soda either. I have veneers.

I have veneers also and the Baking soda has no effect on them........FWIW

[grey_whiskers]

How do oral spirochetes react to

1) Sucrose

2) Glucose

3) Fructose

4) HFCS

5) Insulin

6) Glucagon

??

You can STILL brush your teeth with toothpaste if you like... the Fluoride is still a good idea... but don't be fooled: Even the Arm & Hammer Baking Soda Tooth Paste doesn't have enough baking soda in it to make a difference... Alcohol based mouthwashes don't do it, either.

I once read that alcohol-based mouthwashes have a dessicating effect on the tissues of the mouth and so over time are associated with oral carcinomas.

I switched to cetylpyridinium chloride 0.07% rinse.

Also -- do you know if any OTC preparations such as "PLAX" are effective at breaking up the plaque?

Cheers!

[Revolting cat!]

a neurospirochetosis.

That's what I've been saying all along!

[Hot Tabasco]

It's the Clorox™ brand-name with a blue cap on the bottle.

What about diluted Hydrogen Peroxide?

[Conservativegreatgrandma]

I brush my teeth with a mixture of hydrogen peroxide and baking soda. Maybe I’m on to something and didn’t even know it.

[grey_whiskers]

Does 3% or 1.5% hydrogen peroxide either kill spirochetes or break up plaque?

Cheers!

[Swordmaker]

“First, if you look at what kills spirochetes making plaque in your mouth, you will notice that the key ingredients include four essential oils present in products like Listerine. Further, we have been working with biological chemists who are extracting a wide range of natural chemicals from various botanicals. Some grow bacteria and others kill bacteria but hurt human membranes. Others kill bacteria and are profoundly safe.”

Another thing that that link has wrong is his assertion that the essential oils will do anything to the plaques... he is wrong. There is only one thing that will affect the plaques in the mouth... that is the Sodium Hypochlorite—bleach—that is found in Clorox. It will dissolve it. Unfortunately it will also dissolve human skin.

[Swordmaker]

I was wondering if the blue cap bleach is a specific brand or is it Clorox bleach with a blue cap on the bottle?

Oh, I forgot to mention. You have to make the 20-1 solution up new every day. You can't make up a big batch and keep it. It doesn't keep beyond a few hours at best.

[DLfromthedesert]

Bump for later and thank you!!

[Billthedrill]

Thanks for the ping. As an undergraduate in pathogenic bacteriology I was certain that we had already discovered all the bacteria associated with disease. Then along came Helicobacter pylori, causative agent of stomach ulcers and as of earlier this year, implicated in Parkinson's of all things. Guess we didn't really knew what we thought we did.

So I'd be reluctant to dismiss this one out of hand. And yeah, I'd vote to fund a study or three, if the drowning polar bear studies can spare the cash.