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One drug to rule them all: Researchers find treatment that kills every kind of cancer tumor
New York Post ^ | 03/29/2013 | By MICHAEL BLAUSTEIN

Posted on 03/29/2013 1:51:33 PM PDT by SeekAndFind

Edited on 03/29/2013 2:51:23 PM PDT by Sidebar Moderator. [history]

Researchers might have found the Holy Grail in the war against cancer, a miracle drug that has killed every kind of cancer tumor it has come in contact with.

The drug works by blocking a protein called CD47 that is essentially a "do not eat" signal to the body's immune system, according to Science Magazine.


(Excerpt) Read more at nypost.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: cancer; cure; drug

1 posted on 03/29/2013 1:51:33 PM PDT by SeekAndFind
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To: SeekAndFind

See also here:

http://www.natureworldnews.com/articles/1091/20130329/ultimate-antibody-cures-type-cancer-clinical-tests-video.htm

Ultimate Antibody Cures Every Type Of Cancer In Clinical Tests (VIDEO)

EXCERPT:

Cancer researchers made a groundbreaking discovery by developing a sort-of “Ultimate antibody” — a single treatment that has been shown to kill every type of cancer it was tested on.

The latest developments are based on research that began a decade ago at Stanford School of Medicine, where researchers discovered a link between cancer cells and high levels of a protein called CD47 while studying leukemia. Irving Weissman, the biologist behind the breakthrough, continued to study CD47 and found at a CD47-blocking antibody that could cure some cases of leukemia by stimulating the immune system to recognize cancer cells as invaders.

Now, Weissman has established a link between CD47 and most of primary caners that affect humans, finding that cancer cells always had higher levels of CD47 than healthy cells. The inordinate amounts of CD47 produced by the cancer cells effectively trick the immune system into not destroying the cancer cells.

“What we’ve shown is that CD47 isn’t just important on leukemias and lymphomas,” says Weissman, according to Science magazine. “It’s on every single human primary tumor that we tested.”

Weissman and his team used that observation to develop an antibody that blocks cancer cells’ CD47, causing the body’s immune system to attack the cancerous cells.

In tests on laboratory mice infected with a litany human cancers — breast, ovarian, colon, bladder, brain, liver prostate — the antibody was shown to force the mice’s immune systems to kill the tumorous cells.

“We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis,” said Weissman.

CLICK ABOVE LINK FOR THE VIDEO AND THE REST OF THE ARTICLE...


2 posted on 03/29/2013 1:53:00 PM PDT by SeekAndFind
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To: SeekAndFind

FROM THE VIDEO...

The next step is for clinical tests in humans, which should be underway thanks to a $20 million grant by the California Institute for Regenerative Medicine to move the findings to human safety tests, which was granted in 2012, after the study took place.

“We have enough data already that I can say I’m confident that this will move to phase I human trials,” said Weissman.


3 posted on 03/29/2013 1:53:44 PM PDT by SeekAndFind
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To: SeekAndFind

MORE HERE:

Scientists Have Silver Bullet To Kill Multiple Cancers, Human Trials Starting

Read more at http://www.medicaldaily.com/articles/14434/20130328/cancer-treatment-cd47-miracle-bullet-breast-colon-bladder-antibody-eat-macrophage-immune.htm#WEB82SPJ1c2JQdzj.99

EXCERPT:

Researchers have previously noticed that a specific surface marker, called CD47, was expressed at high levels on cancer cells and cells in the blood. They found that this CD47 molecule signals the immune system to ‘not eat me,’ and protects cells from being killed off. Cancers use this flag to evade the immune system and hide while it grows and eventually spreads through the body, ignored by the immune system.

Recently the lab of Irving Weissman at the Stanford University School of Medicine in Palo Alto, California has treated mice with leukemias and lymphomas with an antibody that blocks and effectively hides this CD47 marker and calls on the immune system to attack and kill the cancerous cells.
Now in the most recent publication, Weissman and his research group has gone a step further and tested multiple types of human cancer cells including breast, ovary, colon, bladder, brain, liver, and prostate tumors in petri dishes and in mice to determine the effectiveness of this ‘Anti-CD47’ antibody treatment.

In vitro, in petri dishes, researchers found that when they blocked this ‘do not eat me’ signal, macrophages, a type of immune cell that eats harmful cells and bacteria, killed and ate the cancer cells. And without the drug, the macrophages ignored the cancer cells completely.

In mice, researchers transferred multiple types of human cancer cells, which would normally grow large, metastasize and eventually kill the mouse. Yet, the mice treated with the drug all had shrinkage of tumors, no evidence of cancer spread to lymph nodes and remained cancer free for four months after researchers stopped the treatment (when the experiment was completed).

From the Science editorial “In mice given human bladder cancer tumors, for example, 10 of 10 untreated mice had cancer that spread to their lymph nodes. Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer.”

The editorial continues: Cancer researcher Tyler Jacks of the Massachusetts Institute of Technology in Cambridge says that although the new study is promising, more research is needed to see whether the results hold true in humans. “The microenvironment of a real tumor is quite a bit more complicated than the microenvironment of a transplanted tumor,” he notes, “and it’s possible that a real tumor has additional immune suppressing effects.”

Weissman’s research laboratory has received a $20 million grant from California Institute for Regenerative Medicine to move from mouse trials to safety tests in humans (Phase I trials).


4 posted on 03/29/2013 1:55:24 PM PDT by SeekAndFind
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To: SeekAndFind

This is very interesting. I just wish the laws were relaxed enough to let people make the informed choice to try it for themselves so doctors could collect the data and get it on the market if findings merit it.


5 posted on 03/29/2013 1:56:24 PM PDT by cripplecreek (REMEMBER THE RIVER RAISIN!)
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To: SeekAndFind

Reports coming in fast...

SEE HERE: http://en.ria.ru/science/20130327/180288463.html

US Scientists Find One Drug to Fight Different Cancers

EXCERPT:

Researchers at the Stanford University School of Medicine in California have discovered a single drug that has killed or shrunk every kind of cancer tumor it has been used against.

The drug blocks a protein called CD47, which cancer cells produce in large amounts and thereby trick the body’s immune system into not destroying the cancer cells. Scientists have created an antibody that blocks CD47, prompting the immune system to attack the cancer cells.

“We showed that even after the tumor had taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis,” biologist Irving Weissman of the Stanford University School of Medicine was quoted by Science Magazine as saying.

The drug was effective against several kinds of cancer tumors that were transplanted into mice, including human breast, ovary, colon, bladder, brain, liver and prostate tumors. In every case the antibody was able to get the mice’s immune system to kill the cancer cells.

“It is the first antibody treatment shown to be broadly effective against a variety of human solid tumors, and the dramatic response … has the investigators eager to begin phase-1 and -2 human clinical trials within the next two years,” the Stanford School of Medicine reported on its website.

The research was published Tuesday on the website of the Proceedings of the National Academy of Sciences.

A decade ago Weissman discovered that leukemia cells produce higher levels of CD47 than healthy cells, Science Magazine reported. And in the last several years, Weissman and his team of researchers discovered that blocking CD47 with an antibody cured some cases of lymphoma and leukemia in mice by stimulating the immune system to see the cancer cells as invaders.

“What we’ve shown is that CD47 isn’t just important on leukemias and lymphomas,” Weissman said. “It’s on every single human primary tumor that we tested.”


6 posted on 03/29/2013 1:57:36 PM PDT by SeekAndFind
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To: SeekAndFind
I'm from Missouri. And I'll probably be dead before somebody shows me.
7 posted on 03/29/2013 1:58:57 PM PDT by Past Your Eyes (Never attribute to malice that which is adequately explained by stupidity.)
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To: cripplecreek

And our govt. will approve it’s use in about 1o to 20 years.


8 posted on 03/29/2013 1:59:18 PM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: cripplecreek
This is NOT interesting at all.;-)

Our government should be funding important things like, for example, the sex lives of snails and ducks...and shrimp jogging on treadmills.

BTW, it is Friday and my cocktail hour begins in 2 minutes.

9 posted on 03/29/2013 2:00:07 PM PDT by RoosterRedux (Get armed, practice in the use of your weapons, get physically fit, stay alert!)
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To: SeekAndFind
I hope they didn't use any current malicious disease viruses to create this antibody.

zombie

10 posted on 03/29/2013 2:01:05 PM PDT by fwdude ( You cannot compromise with that which you must defeat.)
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To: SeekAndFind

Will be withheld from seniors over 72 years old.


11 posted on 03/29/2013 2:01:07 PM PDT by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: SeekAndFind

My uncle just passed from stomach and bone cancer. Though too late for him, this is excellent news!


12 posted on 03/29/2013 2:01:12 PM PDT by taxcontrol
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To: SeekAndFind

I must admit, this line just about slowed me down....
“So far, researchers have used the antibody in mice with human breast”, but I kept on reading and now I don’t have an image in my head of mice with female boobs in a lab somewhere.

Other than that, this is really great news.


13 posted on 03/29/2013 2:03:28 PM PDT by History Repeats (sic transit gloria mundi)
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To: SeekAndFind

Incredible.


14 posted on 03/29/2013 2:04:53 PM PDT by BuckeyeTexan (There are those that break and bend. I'm the other kind. ~Steve Earle)
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To: SeekAndFind

AMA & AHA will buy up rights and it’ll sent to Warehouse 13.


15 posted on 03/29/2013 2:06:33 PM PDT by stylin19a (obama - Fredo smart)
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To: steve86

Unless one is a high ranking elite liberal.


16 posted on 03/29/2013 2:06:44 PM PDT by wally_bert (There are no winners in a game of losers. I'm Tommy Joyce, welcome to the Oriental Lounge.)
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To: fwdude

It’s okay, we’ve got Will Smith.


17 posted on 03/29/2013 2:09:20 PM PDT by EEGator
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To: fwdude

Yeah, I was think about that movie when I read this article — sounds too good to be true. What side-effects will a treatment have if ever developed?


18 posted on 03/29/2013 2:10:23 PM PDT by 3Fingas (Sons and Daughters of Freedom, Committee of Correspondence)
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To: wally_bert
Unless one is a high ranking elite liberal.

Such as most of the Republican senators.

19 posted on 03/29/2013 2:14:33 PM PDT by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: SeekAndFind

Will this disappear just like DRACO?

https://en.wikipedia.org/wiki/DRACO_%28antiviral%29


20 posted on 03/29/2013 2:15:40 PM PDT by Little Ray (How did I end up in this hand-basket, and why is it getting so hot?)
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To: steve86

Depending on useful they were, some would be allowed.


21 posted on 03/29/2013 2:16:25 PM PDT by wally_bert (There are no winners in a game of losers. I'm Tommy Joyce, welcome to the Oriental Lounge.)
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To: SeekAndFind

Bump.


22 posted on 03/29/2013 2:18:53 PM PDT by Sans-Culotte ( Pray for Obama- Psalm 109:8)
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To: History Repeats

Ah, but what kind of mice are they growing? Maybe that is the real story. Who knows what weird stuff they are doing these days. It’ll only get more bizarre in the future when gene manipulation kicks into high gear.


23 posted on 03/29/2013 2:21:07 PM PDT by dhs12345
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To: SeekAndFind

This is irresponsible reporting.
Killing cancer cells in mice is nothing new. Virtually every cancer drug or compound out there did well with testing in mice.
BUT, only a small fraction are able to get approved and pass the initial human trial tests of toxicity before reaching effective dose levels.
Many fail because the liver won’t process them properly.
This product is years away from completing just the Phase1 human trial, if it gets approved for human testing.

There is a drug currently in human trials at the Harvard Cancer complex (Dana Farber Hospital) that has a different MOA from the product hyped in the news releases.
It is Kevetrin, and it is very promising. Several other prominent cancer research hospitals have started or are soon to start additional trials using K with compounds already approved.


24 posted on 03/29/2013 2:22:23 PM PDT by There's millions of'em (Tis a relentless battle for freedom)
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To: cripplecreek
Ya. It is about frikkin time. How many trillions have gone into Cancer research?
25 posted on 03/29/2013 2:22:34 PM PDT by dhs12345
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To: RoosterRedux

Do forget the fat lesbian studies Rooster.
Cheers!
Have one on me.


26 posted on 03/29/2013 2:22:57 PM PDT by Ouchthatonehurt ("When you're going through hell, keep going." - Sir Winston Churchill)
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To: There's millions of'em
Two topics ~ eliminating a protective enzyme from cancer cells so that they get et, and increasing the amount of an anti-cancer cell enzyme so that they die.

All pretty simple concepts and will probably be used together to double your doctor bills!

Just hope those macrophages don't carve holes in your gizzard though.

27 posted on 03/29/2013 2:36:47 PM PDT by muawiyah
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To: SeekAndFind

I’ll be the cynic and say this drug will never make it to human trials.

Way too much money is being made in the treatment of cancer to allow one drug to take down an entire industry. Ain’t gonna happen, which is a shame.


28 posted on 03/29/2013 2:42:00 PM PDT by upchuck (Free Republic: faster than a speeding bullet!)
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To: SeekAndFind

29 posted on 03/29/2013 2:44:40 PM PDT by martin_fierro (< |:)~)
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To: SeekAndFind

And under Obamacare, if youre above the age of 65 with cancer, they’ll refuse to give you this cure. Giving you a pain pill and a pamphlet on assisted suicide instead.


30 posted on 03/29/2013 2:44:42 PM PDT by lowbridge (Joe Biden: "Look, the Taliban per se is not our enemy.")
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To: There's millions of'em

Many promising cancer therapies fail because the human testing is done on people who have already been compromised by chemo therapy. The chemo industry is powerful and doesn’t like any competition.


31 posted on 03/29/2013 2:46:22 PM PDT by aimhigh ( Guns do not kill people. Abortion kills people.)
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To: Past Your Eyes
I'm from Missouri. And I'll probably be dead before somebody shows me.

Yeah

32 posted on 03/29/2013 2:47:55 PM PDT by VRW Conspirator (Cyprus - the beginning)
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To: SeekAndFind

The population control crowd isn’t going to like this.


33 posted on 03/29/2013 2:48:15 PM PDT by mtg
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To: History Repeats

RE: but I kept on reading and now I don’t have an image in my head of mice with female boobs in a lab somewhere.

It says in the article:

mice with human breast, ovary, colon, bladder, brain, liver and prostate TUMORS (my emphasis) transplanted into them.

They did not give the mice human breasts, they gave them HUMAN BREAST TUMORS.


34 posted on 03/29/2013 2:48:27 PM PDT by SeekAndFind
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To: RoosterRedux
BTW, it is Friday and my cocktail hour begins in 2 minutes.

That's taunting... ;-)

35 posted on 03/29/2013 2:51:30 PM PDT by Hoffer Rand (There ARE two Americas: "God's children" and the tax payers)
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To: lowbridge

“Giving you a pain pill and a pamphlet on assisted suicide instead.”

Only the pamphlet is free ...


36 posted on 03/29/2013 4:08:46 PM PDT by PIF (They came for me and mine ... now it is your turn ...)
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To: Ouchthatonehurt
I knew a lesbian who once chased me around the room...I said, I can't, I have a girl friend.

She said, let's pretend we're having a threesome.

Ouch.;-)

37 posted on 03/29/2013 6:03:17 PM PDT by RoosterRedux (Get armed, practice in the use of your weapons, get physically fit, stay alert!)
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To: dhs12345

My thoughts exactly. Prolly about as much as the fed gubmint gets—”we dont wanna find a cure too soon, cuz then we’ll lose our jobs”.


38 posted on 03/29/2013 6:49:54 PM PDT by SgtHooper (The last thing I want to do is hurt you. But it's still on the list.)
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To: SgtHooper

It could have been by design.

And the standard treatment for cancer still isn’t that great. It is brute force — chemo and radiation and surgery. They may have perfected these treatments but the basic technology is decades old.

Something is not right here.


39 posted on 03/29/2013 7:21:15 PM PDT by dhs12345
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To: SeekAndFind

Our current govt will approve this treatment AFTER all the baby boomers are long dead. They have to find a way to sustain Social Security you know. Can’t be lettin those SS/Medicare hangers on live too long you see.


40 posted on 03/30/2013 12:17:19 AM PDT by tinamina
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To: SeekAndFind

Don’t have a sense of humor do you.


41 posted on 03/30/2013 3:15:09 PM PDT by History Repeats (sic transit gloria mundi)
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To: SeekAndFind

Ping


42 posted on 04/02/2013 6:41:18 AM PDT by Clump ( the tree of liberty is withering like a stricken fig tree)
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