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Silver makes antibiotics thousands of times more effective
Nature News ^ | June 19, 2013 | Brian Owens

Posted on 06/21/2013 9:02:11 PM PDT by neverdem

Ancient antimicrobial treatment could help to solve modern bacterial resistance.

Like werewolves and vampires, bacteria have a weakness: silver. The precious metal has been used to fight infection for thousands of years — Hippocrates first described its antimicrobial properties in 400 bc — but how it works has been a mystery. Now, a team led by James Collins, a biomedical engineer at Boston University in Massachusetts, has described how silver can disrupt bacteria, and shown that the ancient treatment could help to deal with the thoroughly modern scourge of antibiotic resistance. The work is published today in Science Translational Medicine1.

“Resistance is growing, while the number of new antibiotics in development is dropping,” says Collins. “We wanted to find a way to make what we have work better.”

Collins and his team found that silver — in the form of dissolved ions(i.e. ionic compounds, aka salts, before being dissolved) — attacks bacterial cells in two main ways: it makes the cell membrane more permeable, and it interferes with the cell’s metabolism, leading to the overproduction of reactive, and often toxic, oxygen compounds. Both mechanisms could potentially be harnessed to make today’s antibiotics more effective against resistant bacteria, Collins says.

Many antibiotics are thought to kill their targets by producing reactive oxygen compounds, and Collins and his team showed that when boosted with a small amount of silver these drugs could kill between 10 and 1,000 times as many bacteria. The increased membrane permeability also allows more antibiotics to enter the bacterial cells, which may overwhelm the resistance mechanisms that rely...

--snip--

Before adding silver to antibiotics, “we’ll have to address the toxicity very carefully”, says Fowler. Ingesting too much silver can also cause argyria, a condition in which the skin turns a blue-grey colour — and the effect is permanent...

(Excerpt) Read more at nature.com ...


TOPICS: Health/Medicine; History; Science
KEYWORDS: antibioticresistance; antibiotics; argyria; boston; curad; massachusetts; microbiology; silver; silverchloride; silverions; silverpoisoning; silversalts
Silver bullets that kill bacteria, not werewolves - Silver engages in a multi-pronged assault on bacteria.

Hat tip yefragetuwrabrumuy, but we can only link Ars Technica.

1 posted on 06/21/2013 9:02:11 PM PDT by neverdem
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To: neverdem

If it aint your time to go, I dont care what the world or the devil throws...

“Science” means nothing to me.


2 posted on 06/21/2013 9:05:40 PM PDT by One Name (Ultimately, the TRUTH is a razor's edge and no man can sit astride it.)
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To: neverdem
Smurf in a bottle...


3 posted on 06/21/2013 9:08:27 PM PDT by ProtectOurFreedom
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To: neverdem

4 posted on 06/21/2013 9:08:56 PM PDT by Neidermeyer (I used to be disgusted , now I try to be amused.)
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To: neverdem

5 posted on 06/21/2013 9:11:22 PM PDT by Teacher317 (Sometimes I've believed as many as six impossible things before breakfast)
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To: neverdem

colloidal silver..lol


6 posted on 06/21/2013 9:12:17 PM PDT by yldstrk (My heroes have always been cowboys)
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To: ProtectOurFreedom
From the link...

Ingesting too much silver can also cause argyria, a condition in which the skin turns a blue-grey colour — and the effect is permanent.

7 posted on 06/21/2013 9:13:29 PM PDT by Jane Long (While Marxists continue the fundamental transformation of the USA, progressive RINOs stay silent.)
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To: neverdem

100 years from now it will be found that the silver resistant bacteria can only be stopped by the saliva of those afflicted with lycanthropy, but then it will be too late.

Freegards


8 posted on 06/21/2013 9:25:51 PM PDT by Ransomed
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To: neverdem

I had a series of wicked spider bites, and after removing the necrotic tissue, they still felt like someone putting cigarettes out on my skin. Curad makes a silver chloride ointment which was the only thing which would stop the pain—an immediate cooling effect. The bites took three months to heal over, and that ointment was my main source of relief. I alternated the silver chloride ointment with triple antibiotic at dressing changes. They never became infected.


9 posted on 06/21/2013 9:40:50 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: ProtectOurFreedom
Is that one of the The Blue People of Troublesome Creek ?
10 posted on 06/21/2013 9:42:21 PM PDT by Slump Tester (What if I'm pregnant Teddy? Errr-ahh -Calm down Mary Jo, we'll cross that bridge when we come to it)
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To: yldstrk; Smokin' Joe

http://www.britannica.com/EBchecked/topic/125898/colloid

http://www.mayoclinic.com/health/colloidal-silver/AN01682

It doesn’t sound like colloidal silver to me. Siver ions are completely dissolved like the sodium ions in table salt in water. Colloids are suspensions; colloidal silver sounds like a suspension of elemental silver, not a silver salt. Silver salts have been used on wounds in medicine for a while, typically burns.


11 posted on 06/21/2013 9:51:26 PM PDT by neverdem (Register pressure cookers! /s)
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To: neverdem
I tried the silver ointment (no,not colloidal silver) because friends had said that colloidal silver might work (topically applied), and I couldn't get any colloidal silver as fast.

If you think about it, though, before the advent of cheap stainless steel, most people ate off of silver plate or silver utensils, even if the base metals were showing through. I would expect trace amounts of silver ended up in their system, and people seemed healthier (although I'll admit nostalgia may colour my memories). Cooking was done in cast iron, and after no-stick (Teflon, because good and well-seasoned cast iron is pretty much non-stick) cookware came out, it seemed like a lot more people had anemia, too.

As for the colloidal silver, I would not expect that to remain metallic in the digestive tract, but would end up as a silver salt (likely a chloride). The trick, of course is not to overdo it. The fellow who has the blue complexion made his own and ODd.

Btw, I prefer Tea Tree Oil on minor burns, after cold running water. Pain relief, and no blistering.

12 posted on 06/21/2013 10:04:54 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: neverdem
I don't take colloidal silver; but, I do use bandages with silver, for small wounds. They are great! Wounds seem to heal more quickly, and there are never infections.


13 posted on 06/21/2013 10:07:42 PM PDT by USFRIENDINVICTORIA
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To: neverdem

They still can’t get it right.

It is the impurities that cause the Argyria, and you have to consume mass quantities to cause it.

If you make your own. Use .9999 pure silver wire, attach the wires outside the glass, keep the voltage and amperage low(3-9V batteries) use only distiled water and filter the precipitates out before you take it. The smallest suspended particles are what you want.

I prefer to buy it in a lab produced, protein concentrate, that can be mixed into juice.

OK, now continue with the inevitable, ignorant, pictures of blue, gray, and green idiots that would OD on water if you told them to drink at least 4 glasses a day.


14 posted on 06/21/2013 10:27:21 PM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afghanistan and Iraq))
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To: One Name
If it aint your time to go, I dont care what the world or the devil throws...

“Science” means nothing to me.

Considering the fact that advancing science has raised life expectancies across the board, the "time to go" part has been altered by humans in the past 100 years to a phenomenal extent.

Even countries with primitive cultures that have been touched by the spell of modern science are seeing the same phenomenon of increased life expectancy.

Man played God in increasing his days and succeeded decades ago. Than science.

15 posted on 06/21/2013 10:29:04 PM PDT by James C. Bennett (An Australian.)
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To: James C. Bennett; All

Than = Thank


16 posted on 06/21/2013 10:30:26 PM PDT by James C. Bennett (An Australian.)
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To: PeaceBeWithYou
They still can’t get it right. It is the impurities that cause the Argyria, and you have to consume mass quantities to cause it.

Exactly! Thanks for that common sense explanation. Of course, you and I know Big Pharma won't allow a natural substance (that can't be patented) to "be found to cure anything" because they can't make money off of it. Colloidal silver has been proven to cure even tough infections like MRSA but you won't hear it in the main stream media.

17 posted on 06/21/2013 11:15:29 PM PDT by ASouthernGrl (BHO sucks - literally or metaphorically, you decide.)
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To: Smokin' Joe

manuka honey will also help wounds not get infected. manuka honey kills all bacteria that comes in contact with it.


18 posted on 06/21/2013 11:31:05 PM PDT by Secret Agent Man (Gone Galt; Not averse to Going Bronson.)
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To: Smokin' Joe

Had a brn recluse bite middle finger...almost had to cut it off..”which would have reduced my ability to respond competitively in heavy traffic by upwards of 50%” any way...after a 25yr old female somoli “ dr.” working for the most Infamous clinic in north america in could not identify the problem ... In desperation I googled it.found out it was a brn recluse bite...anti biotics are good...burning it out with a hot iron is good....but the best apparently is an electric current passing through the wound combined with antibiotics it negates the toxin causing necrosis ...I would like to take this opp. to WARN THE SHT OUT OF ANYONE WITH A BITE donot go to sleep...do not get drunk do not eat pain meds and hope it gets better....Get some anti biotics and fry the wound w heat or a stun gun...do it when its small...dont wait....dont put it off....OF COURSE IM NOT A DR.!you certainly
dont have listen to me....Im just a guy who can still flip you off with EITHER hand because I ate antibiotics and fryed the wound myself while it was still dime size....GLTUA

ps hydrogen peroxide also seems to help debilitate the toxins effect.
pss I think I can climb better now...call me Psychosomatic if ya want I dont care.,........:)


19 posted on 06/21/2013 11:36:45 PM PDT by Therapsid (Communism has killed 50-60 Million people in only 50 yrs.)
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To: ASouthernGrl

I gave up long ago trying to explain Colloidal silver. I can’t imagine any serious prepper not having such a simple device available. The blue man pops up on any silver thread as quick as the “It’s the Aliens” dude on space threads.

Makes one wonder just how smart this community really is.

Then Rubio pops up and I kinda know.


20 posted on 06/22/2013 12:03:17 AM PDT by Gadsden1st
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To: Jane Long

the effect is permanent...

Same can be said about that “death” thingie..

Choose your poison!


21 posted on 06/22/2013 12:17:57 AM PDT by djf (Rich widows: My Bitcoin address is... 1ETDmR4GDjwmc9rUEQnfB1gAnk6WLmd3n6)
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To: neverdem

Old idea. 40 years ago we used to use silver nitrate on burns: but it did make a mess (turned everything black). Now we use Silvadene instead.

The problem is that you can’t just drink it and expect it to work.

And if you take too much of it, your skin turns grey (not dangerous, but ugly).


22 posted on 06/22/2013 12:37:49 AM PDT by LadyDoc (liberals only love politically correct poor people)
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To: Gadsden1st

You would think FReepers would be smarter to read the true story behind that guy instead of buying into the headline.

Colloidal silver is great to use on pets too. It saved my cat’s life a few years ago. He was most likely a day from death. We put some on his wound and dropped some into his mouth. We did this every 2 hours or so and the next morning he was drinking and eating again.

I have 1% silver sulfadiazine cream (Silvadene) that I was prescribed when I was in the hospital for cellulitis. I asked if silver would help heal it, the doctor said it couldn’t hurt. I made sure my doctor keeps it in my list of medicine I use so I can get refills.

I use it on my feet when they crack open - how I got cellulitis both times- on my many cysts and boils, burns and any other wounds like when I fell or the damn crazy cat - not the above cat- scratched the hell out of my leg.


23 posted on 06/22/2013 1:24:23 AM PDT by CARDINALRULES (Tough times never last -Tough people do. DK57 -- 6-22-02)
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To: James C. Bennett; One Name

I prefer to think of it as God blessed the Doctors with knowledge and skill. And God tends to calls those that won’t take advantage of doctors home a little earlier than he calls those that do take advantage of them.


24 posted on 06/22/2013 2:05:31 AM PDT by DannyTN
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To: neverdem

It’s not just silver. Certainly gold, but it’s cost prohibitive. Even copper to an extent. The known antimicrobial benefit of certain metals is more often environmental or topical rather than internal (via ingestion), though.

There are all manner of natural antimicrobials. Salt is a great one. Most of your typical kitchen spice rack. Vinegar. Sugar. Honey. Top of the organic heap would be garlic in various forms, fresh and especially oils.

Then there are various other essential oils used topically. Oil of oregano is powerful. So is melaleuca oil, otherwise known as tea tree oil.

Good old chlorine bleach is greatly underrated as an environmental antimicrobial also.

You’ve got them at your disposal, it’s just that few have been taught to view them in that manner let alone use them for this purpose. The time may be coming that they’re all you have.


25 posted on 06/22/2013 2:33:44 AM PDT by RegulatorCountry
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To: Gadsden1st

You owe me another monitor and a cup of coffee! :)


26 posted on 06/22/2013 3:10:48 AM PDT by poobear (Socialism in the minds of the elites, is a con-game for the serfs, nothing more.)
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To: DannyTN

Premature delivery once used to be a death sentence - they used to not see life outside the womb, at all. We are slowly progressing to the point where soon an artificial womb will first allow better intensive care to those born prematurely, and after that, to produce humans without a natural womb.

You may feel free to pigeon-hole reality however you want in your mind, but the fact is, humans have altered lifespans across countries, across cultures, with the only commonality being the increased application of science, a lot of it developed on the borders of ethics as well. Many vaccines, for example, use products derived from cell lines extracted from human embryos.


27 posted on 06/22/2013 4:43:25 AM PDT by James C. Bennett (An Australian.)
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To: Jane Long

The dosage required to give an adult argyria is magnitudes higher than the dosage that is adequate for medical purposes.

from: Silver Toxicity - How much is harmful?

One tsp. contains 5 ml. of liquid

One ppm concentration is the same as 1 milligram (mg.) per liter
(Example: 10 PPM colloidal silver contains 10 mg of silver in one liter of liquid)
(Example: One tsp. of 10 PPM colloidal silver contains 50 micrograms of silver)

The EPA reference dose for a 160 pound adult (the average amount consumed per day in food and water): 364 micrograms per day.

The EPA critical dose for a 160 pound adult (the amount that should not be exceeded in daily consumption): 1.09 milligrams per day

The EPA proposed limit for silver in drinking water is: 0.1 mg per liter ( 0.1 PPM)

The average person consumes approximately 90 mcg. of silver/day in their food

The estimated dosage of silver required to trigger an anti-infection response (based on anecdotal reports and other data); is believed to be approximately 1 milligram of silver
References (8) and ( 70) state that the estimated total dosage of silver required to treat serious infections such as LYME disease is: Approximately 18 to 90 milligrams of silver over the period of one month.

The estimated accumulated dosage required to produce argyria is: Approximately one to six grams of silver, depending on the reference cited. Some references state as high as 50 grams.(1)(62)

The estimated single dose lethal quantity of silver is: Approximately ten grams of silver (56)

http://www.info-archive.com/colsil%20silvertox.htm


28 posted on 06/22/2013 4:48:55 AM PDT by theBuckwheat
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To: neverdem

Like papa smurf here; http://www.dailymail.co.uk/news/article-1212557/Blue-man-Paul-Karason-blue-self-medicates-silver-skin-condition.html


29 posted on 06/22/2013 4:50:19 AM PDT by nomad
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To: Gadsden1st

I’ve heard a lot of good things about the curing aspects of silver. I’ve even heard about it getting rid of tumours and such.


30 posted on 06/22/2013 5:07:23 AM PDT by Bulwyf
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To: Therapsid
Not sure what got me. There were about 30 little red dots and a few hours later 20+ had become 1/4 inch black spots. Antibiotic and band-aids, the first round, and when I peeled those off, out came plugs of dead meat. I spent the afternoon with a jackknife and a large bottle of hydrogen peroxide I carry in my med bag, scraping out dead meat and irrigating wound sites. No fun.

A couple of debrieding/irrigation sessions later, the mess had stabilized, with the largest bite (open wound) about 5/8-3/4 inch across. they still burned, off and on, and the closest I can describe that is someone putting a cigarette out on the skin. The last of them scabbed over 3 months later--(I went through a LOT of band-aids--a tube of the silver chloride ointment, and a tube of basic triple antibiotic, and every dressing change I irrigated the wound sites with peroxide.

When I finally made it in to see a doctor, he said "I have never seen anything like that". (big help, that)

I did some research on my own and found out about spider bites. Considering, a limited venom load, some bites not festering, multiple bites all seem to point to a hatch in the bedding of the location housing I was staying in. I bagged up the linnens, put them outside (winter), and did not sleep in the bunk for the duration of the job. No new bites.

Next well, I had a different housing unit.

The last and largest to heal scabbed over after roughly 3 months, now it looks like I got hit with a shotgun (both feet, one shin).

31 posted on 06/22/2013 5:29:32 AM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: LadyDoc

Wasn’t it during the Civil War that the first battlefield photographers discovered that silver nitrate used for fixing negative plates also served as an antiseptic to treat wounds?


32 posted on 06/22/2013 6:37:36 AM PDT by elcid1970 ("The Second Amendment is more important than Islam.")
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To: Slump Tester

That condition was genetic, not due to silver consumption.


33 posted on 06/22/2013 6:46:00 AM PDT by tbw2
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To: tbw2

Yeah, I know. Did you read my link? I remember when that was in “Science 82”.


34 posted on 06/22/2013 7:46:56 AM PDT by Slump Tester (What if I'm pregnant Teddy? Errr-ahh -Calm down Mary Jo, we'll cross that bridge when we come to it)
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To: neverdem

Bkmk


35 posted on 06/22/2013 7:49:31 AM PDT by novemberslady
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To: neverdem

BOOKbump


36 posted on 06/22/2013 10:16:50 PM PDT by S.O.S121.500 (Nothing so vexes me as a thief above ground.ENFORCE THE BILL OF RIGHTS! It's the Law.)
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To: elcid1970
I am unsure when it was discovered, but I wouldn't be surprised if the docs used it during the civil war, and "stole" it from the photography plates.

Wikipedia suggests that it was used in the days of Hippocrates.

The southern doctors did all sorts of stuff to try to keep their patients alive. Check this article.link from the Va medical society

And a manual on civil war medicine can be read here if you are interested in the subject.

37 posted on 06/24/2013 12:15:49 AM PDT by LadyDoc (liberals only love politically correct poor people)
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To: neverdem
The precious metal has been used to fight infection for thousands of years — Hippocrates first described its antimicrobial properties in 400 bc — but how it works has been a mystery.

Makes me wonder what miraculous healing effects gold can have on the human body. There's a reason gold has been so valued for thousands of years. What could be more valuable than a fountain of youth, or a cure for everything?

38 posted on 06/24/2013 12:21:10 AM PDT by Lancey Howard
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To: Smokin' Joe
Curad makes a silver chloride ointment which was the only thing which would stop the pain—an immediate cooling effect. The bites took three months to heal over...

I got a minor spider bite 5 or 6 weeks ago - and it hasn't gone away yet - still itches... I'll try the Curad.

39 posted on 06/24/2013 6:10:58 AM PDT by GOPJ (... liberal anger - - the privileged wheeze of entitled brats ... Greenfield)
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To: Smokin' Joe

I could make a horror movie out of that story. People wouldn’t sleep well ever again.


40 posted on 06/24/2013 6:17:58 AM PDT by roofgoat
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To: CARDINALRULES

“I have 1% silver sulfadiazine cream (Silvadene) that I was prescribed when I was in the hospital for cellulitis. I asked if silver would help heal it, the doctor said it couldn’t hurt. I made sure my doctor keeps it in my list of medicine I use so I can get refills.”

My wife was an office RN in a busy family practice.

Our two sons from ages of 9 to their 20’s rode dirt bikes, regular bikes, hiked, played baseball, football and other fun stuff which often resulted in large areas of their outer skin being shredded, known as road rash or baseball sliding rashes.

We started using Silvadene after a serious road rash case with our older son and Adaptic bandages which didn’t remove the clots when they were removed.

The results were so impressive, we bought the largest jar of Silvadene and kept it at home with small jars for my wife’s purse which also served as a EMT bag. Adaptic bandages have also been another well stocked item.

We learned about using Honey applied to the wounds if we felt the Silvadene might get overwhelmed. She would use Silvadene and put the honey on a few hours later.

After their injuries happened, either at home or at the site, my wife would bring out a bottle of hydrogen peroxide to pour or squirt on their wounds to wash out the contaminants. Then, the Silvadene would go on and maybe an Adaptive patch. Now she opens a bottle of Green Tea to wash down a new wound.

Then, Silvadene would be used at regular time periods, before bedtime, in the morning and after school. After the afternoon Silvadene and maybe honey treatment, we tried to leave their wounds uncovered until bedtime to allow the O2 to work.

Both sons survived and are very healthy adults. When they left home for school, they got an emergency wound care kit of Silvadene, Adaptive bandages and Neosporin. They could buy their own honey if needed.

Active grand kids receive the same treatment, and zero infections and one hasn’t missed a day of school in spite of a couple of self inflicted accidents where she looked like a poster child for road rash.

About ten years ago for smaller skin wounds we started using New Skin liquid bandage with an antiseptic in a super glue base. We buy it at Walmart for a couple bucks per bottle.

Sometimes when we fly fish, we can get small skin cracks in the skin around our around our hands and fingers. Since we are always down stream, only God knows what bad stuff is in the water.

About 10 years ago, I got a minor infection on my index finger and remembered what that a doctor friend had recommended the New Skin. I stopped fishing and drove to a pharmacy bought some New Skin an some rubber gloves for casting. I put it on an didn’t fish the rest of that day. In a couple of days, I could go back to fishing without rubber gloves, which I used the next day after treating my skin cracks.

We now have the small bottles of New Skin in our vehicles, er kits, at home, back packs. About a month ago, I was walking barefoot on an ocean beach and sliced a big toe. My wife had me sit down away from the water. She opened a bottle of Green Tea to rinse away the dirt and crud. She let it dry off used one of our New Skin backpack bottles to cover the cut. I stopped bleeding and the New Skin’s super glue did its thing. She went back to my truck and got new socks and my sandals brought them back to where I was setting and applied one more application of New Skin.

A couple of minutes later, we put on the clean sock and sandals and went back to the truck.

It was a pretty good size cut, but the New Skin held it together for the rest of the trip and for a week after we got home. One of her doctors looked at my toe after we got home and said to continue the New Skin for a few more days.
He now has a couple of bottles of New Skin in his er kit for his family and some Green Tea for washing away crud from a new wound.

Serious wounds and bites should be treated by doctor. Avoid hospitals if you can to avoid the bad bugs living in hospitals. Quick ER visits should be okay. Preferably go to your FP or PED’s office for most wounds/bites.

Keep your tetanus shots up to date. If you are bit by a dog or cat, get the owners name and address and to see if the critter has been vaccinated. Dog/cat bites can carry a lot of dangerous pathogens and should be treated by a doctor.


41 posted on 06/24/2013 8:43:19 AM PDT by Grampa Dave ('How empty and dead' were they to let Chris Stevens, one of them , die for 'Obama-Clinton fiction?')
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To: Jane Long

“Ingesting too much silver can also cause argyria...”

This is BS - Old Wives Tale...


42 posted on 06/24/2013 11:20:59 AM PDT by GGpaX4DumpedTea
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To: GGpaX4DumpedTea
Tell that to the author of the linked article. That's where that line is from.

I have no problem with silver....as an antibiotic or otherwise ;)

43 posted on 06/24/2013 11:23:54 AM PDT by Jane Long (While Marxists continue the fundamental transformation of the USA, progressive RINOs stay silent.)
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To: Jane Long

Nor do I have a problem with silver - colloidal silver - I know it does not cause argryia. If silver does, it is when itg is in its ionic form.


44 posted on 06/24/2013 7:17:32 PM PDT by GGpaX4DumpedTea
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