Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Bacterial molecules may prevent inflammatory bowel disease
Science News ^ | July 9, 2013 | Jessica Shugart

Posted on 07/13/2013 5:53:23 PM PDT by neverdem

Common compounds produced by gut microbes quench colitis in mice

Common molecules made by bacteria in the gut may act as chill pills for the immune system. Molecules secreted by intestinal bacteria work to prevent misplaced immune attacks in inflammatory bowel diseases like colitis, a new study finds.

“It is a huge advance,” says Sarkis Mazmanian of Caltech. “This opens up the notion that a very easy and potentially very safe therapy for inflammatory bowel disease could exist.”

Decades of research have hinted that microbes play a role in immune-related diseases such as obesity, allergy, inflammatory bowel disease and colon cancer. But scientists have had difficulty pinpointing direct links between the bacteria in the gut and the army of immune cells that live there.

Some researchers have focused on individual microbial species among the gut’s teeming hordes to see how they affect the immune system. But Wendy Garrett’s team at Harvard University decided to look instead for possible immune tamers among the various molecules that many different bacteria make. The team chose to investigate short-chain fatty acids because bacterial species that make large amounts are in short supply in some people with inflammatory bowel disease.

To see whether the microbial molecules play a role in quieting the immune system, the researchers added them to mice’s drinking water. The animals developed elevated levels of inflammation-dousing regulatory T cells in their colons, the team reports July 4 in Science. The cells work like wet blankets, dampening autoimmune flare-ups before they burn out of control.

The team also found that those short-chain fatty acids protected the mice from an experimental form of colitis, an immune disease that destroys the colon.

Garrett hopes that the acids play the same role in tamping down inflammation in people. Many bacterial species that inhabit the guts of...

(Excerpt) Read more at sciencenews.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: colitis; crohnsdisease; dietaryfiber; glyphosate; gmo; ibd; immunology; roundup; shortchainfattyacids; ulcerativecolitis

1 posted on 07/13/2013 5:53:24 PM PDT by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

One word...sauerkraut.


2 posted on 07/13/2013 5:55:46 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Two words...Kefir grains.


3 posted on 07/13/2013 5:56:32 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 1 | View Replies]

To: gorush

Three words: “handful of dirt”.


4 posted on 07/13/2013 5:57:29 PM PDT by Born to Conserve
[ Post Reply | Private Reply | To 3 | View Replies]

To: Born to Conserve

I’ll try it. :{)


5 posted on 07/13/2013 5:58:14 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 4 | View Replies]

To: neverdem

6 posted on 07/13/2013 5:59:10 PM PDT by bgill (This reply was mined before it was posted.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: gorush

Diatomaceous earth.


7 posted on 07/13/2013 6:04:36 PM PDT by bgill (This reply was mined before it was posted.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: bgill
I'll stick with Activa at the advice of my Doc, it's worked for me .
8 posted on 07/13/2013 6:07:25 PM PDT by jazusamo ("I am so old that I can remember when most of the people promoting race hate were white." T. Sowell)
[ Post Reply | Private Reply | To 7 | View Replies]

To: bgill

wheat beer


9 posted on 07/13/2013 6:07:38 PM PDT by volunbeer (We must embrace austerity or austerity will embrace us)
[ Post Reply | Private Reply | To 7 | View Replies]

To: Born to Conserve; bgill

You guys can laugh but your stomach bacteria can affect your well being in big ways. I have arrived at this conclusion after a regime of experimentation carried out by my wife...on me.


10 posted on 07/13/2013 6:09:07 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 4 | View Replies]

To: gorush

Many years I heard a dr say to have a bit of sauerkraut every day.


11 posted on 07/13/2013 6:09:37 PM PDT by presently no screen name
[ Post Reply | Private Reply | To 2 | View Replies]

To: afnamvet

Ping


12 posted on 07/13/2013 6:11:23 PM PDT by neverdem (Register pressure cookers! /s)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Two Words:

Fecal Transplant

http://en.wikipedia.org/wiki/Fecal_bacteriotherapy


13 posted on 07/13/2013 6:13:56 PM PDT by HangnJudge
[ Post Reply | Private Reply | To 1 | View Replies]

To: presently no screen name

yup


14 posted on 07/13/2013 6:14:47 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 11 | View Replies]

To: HangnJudge

I suffer from fecalphelia


15 posted on 07/13/2013 6:15:44 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 13 | View Replies]

To: neverdem

Probiotics, and the good stuff!


16 posted on 07/13/2013 6:18:55 PM PDT by goodwithagun (My gun has killed fewer people than Ted Kennedy's car.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: gorush
fecalphelia

An extreme infatuation with feces?

17 posted on 07/13/2013 6:22:28 PM PDT by HangnJudge
[ Post Reply | Private Reply | To 15 | View Replies]

To: neverdem

I take a daily capsule of probiotics, which has been beneficial for me. Basically, the idea is that the good bacteria crowd out the bad ones.

This report seems to be along those lines, although it’s a more specific kind of treatment.


18 posted on 07/13/2013 6:23:57 PM PDT by Cicero (Marcus Tullius)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
excerpt: “It is a huge advance,” says Sarkis Mazmanian of Caltech. “This opens up the notion that a very easy and potentially very safe therapy for inflammatory bowel disease could exist.”

Why is this “news”?

article below from some years ago -
excerpt: “According to Dr. Campbell-McBride, 84 percent of your immunity is located in your gut wall. And if you don't have healthy gut flora, your immune system simply can't function optimally.”

And it wasn't ‘news’ then. People just jumping on the bandwagon to get a slice of the ‘research’ pie?

http://products.mercola.com/gaps-diet/

19 posted on 07/13/2013 6:29:04 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 1 | View Replies]

To: HangnJudge

It was a South Park joke from years ago.


20 posted on 07/13/2013 6:29:43 PM PDT by gorush (History repeats itself because human nature is static)
[ Post Reply | Private Reply | To 17 | View Replies]

To: gorush

Yes, sauerkraut! We also drink home brewed kefir from raw goats milk and home brewed kombucha. We think we have our gut bases covered.


21 posted on 07/13/2013 6:33:15 PM PDT by MomwithHope (Buy and read The Liberty Amendments by Mark Levin!)
[ Post Reply | Private Reply | To 2 | View Replies]

To: Cicero

capsules of food?

excerpt:
“each mouthful of fermented food can provide trillions of beneficial bacteria—far more than you can get from a probiotics supplement, which will typically provide you with colony-forming units in the billions.”

http://articles.mercola.com/sites/articles/archive/2012/07/14/gut-microbes-for-healthy-immune-system.aspx#!


22 posted on 07/13/2013 6:37:07 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 18 | View Replies]

To: MomwithHope

I think you do! ;o)


23 posted on 07/13/2013 6:38:30 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 21 | View Replies]

To: maine-iac7

oops “capsules OR food”

(broke my reading glasses today - having a hard time!


24 posted on 07/13/2013 6:39:41 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 22 | View Replies]

To: gorush
Change in Gut Flora May Drive Surgical Weight Loss
25 posted on 07/13/2013 6:39:47 PM PDT by Straight Vermonter (Posting from deep behind the Maple Curtain)
[ Post Reply | Private Reply | To 10 | View Replies]

To: maine-iac7

Our kraut is homemade too and I also do kosher pickles. The kraut is tops in my book. I call it natures brillo pad.


26 posted on 07/13/2013 6:39:58 PM PDT by MomwithHope (Buy and read The Liberty Amendments by Mark Levin!)
[ Post Reply | Private Reply | To 23 | View Replies]

To: MomwithHope
natures brillo pad.

I like s'kraut - but in small doses.

However, I really like Kosher dills - and pepperoni (also fermented)

27 posted on 07/13/2013 6:43:34 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 26 | View Replies]

To: MomwithHope

oh - and ‘real’ cheese


28 posted on 07/13/2013 6:44:20 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 26 | View Replies]

To: maine-iac7

Yes I make real cheese from our goats milk, cream cheese, fresh mozzarella and a couple other kinds. I like the cream cheese (soft chevre) because it’s made at 72 degrees and all the good enzymes and vitamins are not roached.


29 posted on 07/13/2013 6:47:43 PM PDT by MomwithHope (Buy and read The Liberty Amendments by Mark Levin!)
[ Post Reply | Private Reply | To 28 | View Replies]

To: HangnJudge; gorush
Fecalphelia

An extreme infatuation with feces?

Actually the proper term is coprophilia.

30 posted on 07/13/2013 6:52:19 PM PDT by Pontiac (The welfare state must fail because it is contrary to human nature and diminishes the human spirit.)
[ Post Reply | Private Reply | To 17 | View Replies]

To: MomwithHope

I was at a farmers market today where they had samples of their goat cheese. I passed.


31 posted on 07/13/2013 7:21:36 PM PDT by darkangel82
[ Post Reply | Private Reply | To 29 | View Replies]

To: gorush

“You guys can laugh...”
No, seriously, a handful of dirt. We evolved with dirt all over the place. It is what is missing in our diets. Eating less and eating dirt, will make you healthy. No joke.


32 posted on 07/13/2013 7:26:09 PM PDT by Born to Conserve
[ Post Reply | Private Reply | To 10 | View Replies]

To: MomwithHope

wow that sounds good lol! I love cheese.


33 posted on 07/13/2013 7:32:16 PM PDT by visualops (artlife.us)
[ Post Reply | Private Reply | To 29 | View Replies]

short-chain fatty acids bump


34 posted on 07/13/2013 7:33:03 PM PDT by Gene Eric (Don't be a statist!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: MomwithHope
Yes I make real cheese from our goats milk, cream cheese, fresh mozzarella and a couple other kinds. I like the cream cheese (soft chevre) because it’s made at 72 degrees and all the good enzymes and vitamins are not roached.

Great!

I think a lot more people would make cheese if they realized that it's quite easy - especialy the solf cheeses

35 posted on 07/13/2013 11:19:19 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
[ Post Reply | Private Reply | To 29 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson