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Bacterial molecules may prevent inflammatory bowel disease
Science News ^ | July 9, 2013 | Jessica Shugart

Posted on 07/13/2013 5:53:23 PM PDT by neverdem

Common compounds produced by gut microbes quench colitis in mice

Common molecules made by bacteria in the gut may act as chill pills for the immune system. Molecules secreted by intestinal bacteria work to prevent misplaced immune attacks in inflammatory bowel diseases like colitis, a new study finds.

“It is a huge advance,” says Sarkis Mazmanian of Caltech. “This opens up the notion that a very easy and potentially very safe therapy for inflammatory bowel disease could exist.”

Decades of research have hinted that microbes play a role in immune-related diseases such as obesity, allergy, inflammatory bowel disease and colon cancer. But scientists have had difficulty pinpointing direct links between the bacteria in the gut and the army of immune cells that live there.

Some researchers have focused on individual microbial species among the gut’s teeming hordes to see how they affect the immune system. But Wendy Garrett’s team at Harvard University decided to look instead for possible immune tamers among the various molecules that many different bacteria make. The team chose to investigate short-chain fatty acids because bacterial species that make large amounts are in short supply in some people with inflammatory bowel disease.

To see whether the microbial molecules play a role in quieting the immune system, the researchers added them to mice’s drinking water. The animals developed elevated levels of inflammation-dousing regulatory T cells in their colons, the team reports July 4 in Science. The cells work like wet blankets, dampening autoimmune flare-ups before they burn out of control.

The team also found that those short-chain fatty acids protected the mice from an experimental form of colitis, an immune disease that destroys the colon.

Garrett hopes that the acids play the same role in tamping down inflammation in people. Many bacterial species that inhabit the guts of...

(Excerpt) Read more at sciencenews.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: colitis; crohnsdisease; dietaryfiber; glyphosate; gmo; ibd; immunology; roundup; shortchainfattyacids; ulcerativecolitis
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1 posted on 07/13/2013 5:53:24 PM PDT by neverdem
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To: neverdem

One word...sauerkraut.


2 posted on 07/13/2013 5:55:46 PM PDT by gorush (History repeats itself because human nature is static)
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To: neverdem

Two words...Kefir grains.


3 posted on 07/13/2013 5:56:32 PM PDT by gorush (History repeats itself because human nature is static)
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To: gorush

Three words: “handful of dirt”.


4 posted on 07/13/2013 5:57:29 PM PDT by Born to Conserve
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To: Born to Conserve

I’ll try it. :{)


5 posted on 07/13/2013 5:58:14 PM PDT by gorush (History repeats itself because human nature is static)
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To: neverdem

6 posted on 07/13/2013 5:59:10 PM PDT by bgill (This reply was mined before it was posted.)
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To: gorush

Diatomaceous earth.


7 posted on 07/13/2013 6:04:36 PM PDT by bgill (This reply was mined before it was posted.)
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To: bgill
I'll stick with Activa at the advice of my Doc, it's worked for me .
8 posted on 07/13/2013 6:07:25 PM PDT by jazusamo ("I am so old that I can remember when most of the people promoting race hate were white." T. Sowell)
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To: bgill

wheat beer


9 posted on 07/13/2013 6:07:38 PM PDT by volunbeer (We must embrace austerity or austerity will embrace us)
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To: Born to Conserve; bgill

You guys can laugh but your stomach bacteria can affect your well being in big ways. I have arrived at this conclusion after a regime of experimentation carried out by my wife...on me.


10 posted on 07/13/2013 6:09:07 PM PDT by gorush (History repeats itself because human nature is static)
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To: gorush

Many years I heard a dr say to have a bit of sauerkraut every day.


11 posted on 07/13/2013 6:09:37 PM PDT by presently no screen name
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To: afnamvet

Ping


12 posted on 07/13/2013 6:11:23 PM PDT by neverdem (Register pressure cookers! /s)
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To: neverdem

Two Words:

Fecal Transplant

http://en.wikipedia.org/wiki/Fecal_bacteriotherapy


13 posted on 07/13/2013 6:13:56 PM PDT by HangnJudge
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To: presently no screen name

yup


14 posted on 07/13/2013 6:14:47 PM PDT by gorush (History repeats itself because human nature is static)
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To: HangnJudge

I suffer from fecalphelia


15 posted on 07/13/2013 6:15:44 PM PDT by gorush (History repeats itself because human nature is static)
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To: neverdem

Probiotics, and the good stuff!


16 posted on 07/13/2013 6:18:55 PM PDT by goodwithagun (My gun has killed fewer people than Ted Kennedy's car.)
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To: gorush
fecalphelia

An extreme infatuation with feces?

17 posted on 07/13/2013 6:22:28 PM PDT by HangnJudge
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To: neverdem

I take a daily capsule of probiotics, which has been beneficial for me. Basically, the idea is that the good bacteria crowd out the bad ones.

This report seems to be along those lines, although it’s a more specific kind of treatment.


18 posted on 07/13/2013 6:23:57 PM PDT by Cicero (Marcus Tullius)
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To: neverdem
excerpt: “It is a huge advance,” says Sarkis Mazmanian of Caltech. “This opens up the notion that a very easy and potentially very safe therapy for inflammatory bowel disease could exist.”

Why is this “news”?

article below from some years ago -
excerpt: “According to Dr. Campbell-McBride, 84 percent of your immunity is located in your gut wall. And if you don't have healthy gut flora, your immune system simply can't function optimally.”

And it wasn't ‘news’ then. People just jumping on the bandwagon to get a slice of the ‘research’ pie?

http://products.mercola.com/gaps-diet/

19 posted on 07/13/2013 6:29:04 PM PDT by maine-iac7 (Christian is as Christian does - by their fruits)
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To: HangnJudge

It was a South Park joke from years ago.


20 posted on 07/13/2013 6:29:43 PM PDT by gorush (History repeats itself because human nature is static)
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