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A New US/Japan Variant To Watch: R.1 has a set of unique mutations that may confer an additional advantage in transmission, replication, and immune suppression.
Forbes ^ | 09/20/2021 | Michael Haseltine

Posted on 09/23/2021 6:34:07 PM PDT by SeekAndFind

A new variant has been detected in a Kentucky nursing home, infecting 45 residents and health care personnel. Many of these infections arose in fully vaccinated individuals. The variant, which originated in Japan, has over 10,000 entries in the GISAID SARS-CoV-2 database. The variant contains five mutations previously noted in variants of concern or interest, two of which are in the Spike protein (Figure 1). It also contains many unique mutations. Here we describe the potential effects of each mutation on replication, immune evasion, and pathogenesis.


Mutations in R.1 found in other variants. Those in red are unique to R.1. ACCESS HEALTH INTERNATIONAL

The Triad

The R.1 variant shares a common origin with all variants of interest or concern. They are marked by what I call the Triad, three mutations, one the 5’ untranslated region: C241U, a second in the viral polymerase NSP12: P323L, and the third D614G in the exterior S1 domain of the spike protein. The D614G mutation increases the infectivity. The contribution of the other two members of the Triad remains a mystery. Together these three mutations characterize the first major variant first observed in early 2020. That virus soon displaced almost all of the original Wuhan isolates. The Triad virus is the parent of all variants of concern or, interest including Alpha, Beta, Gamma, Delta, Lambda, and Mu. Only two currently circulating variants, A.30 and A.23.1, both of East Africa origin, lack the Triad and are most likely independent descendants of the original Wuhan virus.

The spike protein of SARS-CoV-2 binds the host ACE2 receptor and initiates infection. The R.1 variant contains three Spike mutations, two of which are previously noted in other variants the other which is unique.


(Excerpt) Read more at forbes.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: andagain; chinavirus; coronaviru; mutation; r1; r1variant; variant; variants
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AUTHOR CONCLUDES

R.1 is a variant to watch. It has established a foothold in both Japan and the United States. In addition to several mutations notably in the spike and nucleocapsid protein in common with variants of concern, R.1 has a set of unique mutations that may confer an additional advantage in transmission, replication, and immune suppression.
1 posted on 09/23/2021 6:34:07 PM PDT by SeekAndFind
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To: SeekAndFind

Or not.

There is no science going on.

It is all propaganda targeted at fundamental transformation.


2 posted on 09/23/2021 6:39:47 PM PDT by E. Pluribus Unum ("Communism is not love. Communism is a hammer which we use to crush the enemy." ― Mao Zedong)
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To: SeekAndFind

There’s thousands of viruses in the world...this will never end


3 posted on 09/23/2021 6:42:13 PM PDT by goodnesswins (The issue is never the issue. The issue is always the revolyution." -- Saul Alinksy)
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To: SeekAndFind

Wake me up when we get to the R2D2, C3PO or Death Star variant.


4 posted on 09/23/2021 6:43:03 PM PDT by MagnoliaB ( You can't always get what you want but if you try sometime you will find you get what you need.)
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To: SeekAndFind
Have any of the top people in Xi's administration died of COVID?
5 posted on 09/23/2021 6:45:23 PM PDT by GOPJ (Same people who supplied pallets of bricks for BLM are supplying tent poles for illegals.)
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To: MagnoliaB

Lol!


6 posted on 09/23/2021 6:45:23 PM PDT by EvilCapitalist (Pets are no substitute for children.)
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To: SeekAndFind

Sure it does.

Why should this information be accurate or truthful when all the government has done concerning this scamdemic is lie to us?


7 posted on 09/23/2021 6:47:16 PM PDT by SoConPubbie (Mitt and Obama: They're the same poison, just a different potency)
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To: SeekAndFind

Hey let’s just keep jabbing people that seems to be a great approach. /s


8 posted on 09/23/2021 6:47:55 PM PDT by tatown
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To: goodnesswins

Remember when Obama was inviting Ebola patients into the US?


9 posted on 09/23/2021 6:51:01 PM PDT by RushIsMyTeddyBear (RIP my "teddy bear". )
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R.1 variant a/k/a “The Midterm Variant”


10 posted on 09/23/2021 6:55:05 PM PDT by JonPreston (Q: Never have so many, been so wrong, so often)
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To: RushIsMyTeddyBear

Yup.


11 posted on 09/23/2021 6:56:06 PM PDT by EvilCapitalist (Pets are no substitute for children.)
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To: SeekAndFind

The variant contains five mutations previously noted in variants of concern or interest…

R.1. The One Ring mutant.


12 posted on 09/23/2021 7:00:23 PM PDT by Flick Lives (We may or may not have reached herd immunity, but we've definitely achieved herd stupidity.)
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To: tatown

Maybe, just maybe, the same jab that didn’t work the first time will work this time.


13 posted on 09/23/2021 7:07:13 PM PDT by matt04 ( )
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To: GOPJ

Have any Democrat political leaders died from Covid?


14 posted on 09/23/2021 7:07:24 PM PDT by Baldwin77 (Traitor Joe is NOT my president)
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To: matt04

….or maybe the time after that.


15 posted on 09/23/2021 7:08:38 PM PDT by tatown
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To: MagnoliaB

I find your lack of faith disturbing...


16 posted on 09/23/2021 7:10:29 PM PDT by bobby.223 (Retired up in the snowy Mountains of the American Redoubt and it's a great life!)
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To: SeekAndFind

Quite the devilish little bug that Fauci and the Chinese have cooked up.


17 posted on 09/23/2021 7:10:31 PM PDT by Lurkinanloomin ( )
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To: goodnesswins

My god the world has gone insane. We are regressing rapidly.


18 posted on 09/23/2021 7:12:24 PM PDT by shanover (...To disarm the people is the best and most effectual way to enslave them.-S.Adams)
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To: GOPJ
Have any of the top people in Xi's administration died of COVID?

Were there any justice in the world, they would have all died from a heavy dose of gamma radiation by now.

19 posted on 09/23/2021 7:13:04 PM PDT by noiseman (The only thing necessary for the triumph of evil is for good men to do nothing.)
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To: MagnoliaB

They need to rename this R1 crap. We were fine doing Revenge of the Nerds variants previously.


20 posted on 09/23/2021 7:13:53 PM PDT by EEGator
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