They put Basil in the ratatouille????
Posted on 10/05/2021 8:21:55 AM PDT by ConservativeMind
Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer's disease pathology.
…Then, they performed large-scale virtual screening of more than 144,000 natural compounds to find potential candidates that could mimic the same beneficial effect of microbiota produced SCFAs in activating FFAR2 signaling. Identifying a natural compound alternative to SCFAs to optimally target the FFAR2 receptor on neurons is important, because cells in the gut and other organs consume most of these microbial metabolites before they reach the brain through blood circulation, Dr. Yadav noted.
Dr. Yadav's team narrowed 15 leading compound candidates to the most potent one. Fenchol, a plant-derived compound that gives basil its aromatic scent, was best at binding to the FFAR's active site to stimulate its signaling.
Further experiments in human neuronal cell cultures, as well as Caenorhabditis (C.) elegans (worm) and mouse models of Alzheimer's disease demonstrated that fenchol significantly reduced excess Aβ accumulation and death of neurons by stimulating FFAR2 signaling, the microbiome sensing mechanism. When the researchers more closely examined how fenchol modulates Aβ-induced neurotoxicity, they found that the compound decreased senescent neuronal cells, also known as "zombie" cells, commonly found in brains with Alzheimer's disease pathology.
Zombie cells stop replicating and die a slow death. Meanwhile, Dr. Yadav said, they build up in diseased and aging organs, create a damaging inflammatory environment, and send stress or death signals to neighboring healthy cells, which eventually also change into harmful zombie cells or die.
"Fenchol actually affects the two related mechanisms of senescence and proteolysis," Dr. Yadav said of the intriguing preclinical study finding. "It reduces the formation of half-dead zombie neuronal cells and also increases the degradation of (nonfunctioning) Aβ, so that amyloid protein is cleared from the brain much faster."
(Excerpt) Read more at medicalxpress.com ...
Herbs are good.
They put Basil in the ratatouille????
I love me some basil.
My wife has 3 large, flowering and fragrant Basil plants in one of her horse watering troughs.
Then, we have one near to our char-coaling area. I cut the Basil and some near by rosemary and dampen them. When it is time to put the main course on the barbq, I toss half of the rosemary and basil on a side of the grill and close the cover.
When it is time to turn the main course on the grill, I turn it and throw what is left of the herbs to the other side to finish our dinner.
Well, you need to cover up with something when in public, when you are “without pants.”
Looks like lunch will be a pizza with basil pesto sauce.
Hmm interesting.
Will a basil drop or supplement do the same thing?
Is holy basil contain wholly different compounds?
I already had basil and pepperoni sandwiches scheduled for today’s meal. I don’t know if I’ll get any more out of my garden before cold weather finishes it off, but I do have a few containers of chopped basil in my freezer to get me through the winter.
First thing I thought of.
Snack: Toothpick. Cherry Tomato. Mozzarella ball (ciliegne). Basil. YUM!
Thanks for your post.
Hmmmm....
A little basil, Extra Virgin Olive Oil, Garlic, roasted pine nuts and fresh parmesan..
Yep....I’m cured...
How do you prepare it for freezing?
*
Pesto is the besto.
I chop the leaves with a chopping knife. Put the chopped up leaves in a 1 quart container and pour some olive oil over them. Stir it all up well to get all the leaf surfaces coated with oil. Transfer the oil coated leaves into 1 cup plastic containers and press down to get most of the air out to save space. Put the 1 cup containers in the freezer. You can cut off as much as you want off a frozen chunk of leaves as needed.
If you don't coat them with oil before freezing, the leaves turn black. When you coat them with oil they stay green and don't oxidize and lose their flavor and nutritional content.
You’re welcome! Always trying to find ways to get good nutrients!
That’s close to how I’ve been doing it , except I used an ice cube tray, and popped out what I needed. I used a little too much oil, I’ll have to use less next time.
Thanks for posting - perfect solution...
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