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Vaccine could stop MS in its tracks
New Scientist ^ | 03.09.06 | Andy Coghlan

Posted on 03/10/2006 5:42:57 PM PST by Coleus

THE immune cells that attack the brains and nerves of people with multiple sclerosis could be turned into a weapon against the disease.

This month sees the beginning of a trial of a personalised vaccine for MS, designed to rein in and destroy the renegade white blood cells that attack myelin cells lining the brain and nerves of patients.

To make the vaccine, PharmaFrontiers of Woodlands, Texas, takes blood from an MS patient and extracts a sample of these renegade cells. The cells are then multiplied and weakened with radiation before being re-injected into the patient, whose immune system will then recognise them as damaged and attack them, sometimes wiping them out completely, according to the results of earlier trials. The immune system will also attack healthy renegade cells, which have the same markers on their surface. In one trial of 15 people with MS the rate of new flare-ups was reduced by 92 per cent.

If this success is repeated in the new trial it might mean that regular shots could slow or even arrest progression of the disease. "If that's the case, the earlier we can do it after diagnosis the better," says David McWilliams of PharmaFrontiers. In the current trial, 100 patients will receive the treatment and 50 a dummy treatment. The vaccine would only need to be injected four times a year, while other MS drugs need to be given on a weekly or daily basis.

However, since all previous attempts to develop a vaccine for MS have failed, Richard Rudick of the Mellen Center for Multiple Sclerosis Treatment and Research in Cleveland, Ohio, is cautious about its prospects. "None have worked so far. This one may, but we don't yet know."

In the meantime, good news may await MS patients in the US. This week the US Food and Drug Administration is expected to lift its ban on prescribing Tysabri following new evidence on its safety and effectiveness. Tysabri, which is twice as effective at quelling symptoms as any other MS drug available, was pulled a year ago after three people taking it died from rare brain infections.

The superiority of Tysabri over existing, beta-interferon treatments was shown by three separate studies published in The New England Journal of Medicine last week (vol 354, p 899, p 911 and p 924). "With interferons, we've normally seen roughly a one-third reduction in the relapse rate," says Rudick, who led one of the studies. "With Tysabri, we saw more than a two-thirds reduction."

From issue 2542 of New Scientist magazine, 09 March 2006, page 12


TOPICS: Culture/Society
KEYWORDS: brain; cns; ms; multiplesclerosis; neural; neuralcells; neuroligicaldisorder; neurons; spinalcord; vaccine; vaccines

1 posted on 03/10/2006 5:43:00 PM PST by Coleus
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To: Coleus

The headline led me to think the story was about computers. I need to spend less time on this stupid thing.


2 posted on 03/10/2006 5:48:23 PM PST by EricT. ("I reject your reality and substitute my own."-Adam Savage)
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To: Coleus; cgk; afraidfortherepublic

Good news MS ping.


3 posted on 03/10/2006 5:53:34 PM PST by Incorrigible (If I lead, follow me; If I pause, push me; If I retreat, kill me.)
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To: Coleus

bttt.


4 posted on 03/10/2006 6:00:45 PM PST by jeremiah (Anyone got a tagline for rent?)
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To: Coleus

Those eeeeevvvil drug companies are doint it again! I'll bet that they even want to be PAID!


5 posted on 03/10/2006 6:35:04 PM PST by Blood of Tyrants (G-d is not a Republican. But Satan is definitely a Democrat.)
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To: Incorrigible

This is good news.

Lets hope it works.


6 posted on 03/10/2006 6:48:01 PM PST by Syncro
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To: Blood of Tyrants
I'll bet that they even want to be PAID!

Hell I want to be paid! I backed in the pickup and filled it up with ELN when it was between $5 & $6. Holding out for $18 at least.

7 posted on 03/10/2006 8:01:46 PM PST by atomic_dog
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To: SuziQ

Ping for Peggy ...


8 posted on 03/10/2006 8:03:59 PM PST by SirKit (Truth is Precious---The Truth is of the Essence of God)
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To: Blood of Tyrants

Gee, I thought that all vaccines are bad, and that Big Pharma is out to give our kids autism and push vaccines through the FDA Fast Track process so that they can make tons of money before finding out the vaccine causes harm...

Before anyone flames me, yes, I realize that this is a vaccine for adults (as kids don't get MS). However, on the subject of vaccines, many conservatives are getting to sound like liberals: the evil drug company doesn't care about the patients, all they care about is money, it's a conspiracy, etc. etc. etc.


9 posted on 03/10/2006 8:04:29 PM PST by Born Conservative (Chronic Positivity - http://jsher.livejournal.com/)
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To: Coleus

for later


10 posted on 03/10/2006 8:04:54 PM PST by muir_redwoods (Free Sirhan Sirhan, after all, the bastard who killed Mary Jo Kopechne is walking around free)
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To: Coleus

BUMP!


11 posted on 03/10/2006 8:08:41 PM PST by Lancey Howard
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To: Coleus
Wish this had come sooner. I have an uncle with MS who is a near-immobile shell of his once athletic and vital self.
12 posted on 03/10/2006 8:39:03 PM PST by Denver Ditdat (Melting solder since 1975)
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To: SirKit

That's awesome news!


13 posted on 03/11/2006 12:25:21 PM PST by SuziQ
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To: Coleus

This is actually quite promising (for once) - if the FDA and the trial lawyers don't screw it up.


14 posted on 03/11/2006 12:30:43 PM PST by Jim Noble (And you know what I'm talkin' 'bout!)
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To: Jim Noble


You're right.
BTTT


15 posted on 03/11/2006 12:31:59 PM PST by onyx (IF ONLY 10% of Muslims are radical, that's still 120 MILLION who want to kill us.)
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To: Coleus

Excellent news.


16 posted on 03/11/2006 12:32:25 PM PST by Centurion2000 (Islam's true face: http://makeashorterlink.com/?J169127BC)
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To: Coleus; Iwo Jima; longhair; YankeeGirl; PoplarWill; DYngbld; octobersky; Incorrigible; ...
Thank you for the head's up, Incorrigible!


MS ping!

Please FReepmail me if you would like to be added to, or removed from, the Multiple Sclerosis ping list...

17 posted on 03/11/2006 4:09:42 PM PST by cgk (I don't see myself as a conservative. I see myself as a religious, right-wing, wacko extremist.)
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To: Coleus; cva66snipe; Iwo Jima; longhair; YankeeGirl; PoplarWill; DYngbld; octobersky; ...
Israel is also trying out a vaccine on MS patients:

Israeli researcher closes in on vaccine for autoimmune diseases

Excerpt: A revolutionary approach developed in Israel which uses the body's own cells as a vaccine for treating autoimmune diseases is showing tremendous potential in human trials.

The most recent trials are taking place at Sheba Hospital and Hadassah Ein Kerem Hospital, where multiple sclerosis patients are being vaccinated in hope that it will slow down the deteriorative effects of their disease. The results of the double-blind studies are expected to be released in coming months.

The trials are based on scientific research dating back 25 years to the laboratory of Prof. Irun Cohen of the Weizmann Institute. In 1981, Cohen and one of his students, Avraham Bin-Nun, first published their observation that the cells that trigger autoimmune diseases - called T-cells - can be adapted to vaccinate the body against their destructive action. T-cells are a subset of lymphocytes that play a large role in the immune response. The abbreviation "T" stands for thymus, the organ in which their final stage of development occurs.

18 posted on 03/12/2006 3:40:30 PM PST by cgk (I don't see myself as a conservative. I see myself as a religious, right-wing, wacko extremist.)
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To: Coleus

bump


19 posted on 03/12/2006 6:17:08 PM PST by KSCITYBOY
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To: Born Conservative

The pharmaceutical companies are incentivized to succeed at finding cures. When they find a cure they get profits and resulting stock price increases. The successful individual researchers get money and incredible prestige.

There is so much research going on now. The research is in many areas, governmental research, pharmaceutical company research, MS Society sponsored research and independent researchers. The myelin rebuilding studies are especially hopeful.

This "vaccine" is just one of many potential bright spots. We are going to win, it is just a matter of time.


20 posted on 03/13/2006 9:36:54 PM PST by 2ndClassCitizen
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To: Born Conservative
i bet that once the drug companies take out the mercury and make the MMR vaccine into 3 separate vaccines, you will see many of the anti-vaccine people come around.
21 posted on 03/28/2006 10:08:57 PM PST by Coleus (What were Ted Kennedy & his nephew doing on Good Friday, 1991? Getting drunk and raping women)
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To: Coleus
Hoping for a breakthrough here. The key is that those "renegade cells" that attack the myelin sheath are also a part of the immune system that eliminates their damaged counterparts. It is essentially using the immune system to counter an autoimmune reaction, which is pretty slick.

Crossing my fingers. A lot of people would get their lives back.

22 posted on 03/28/2006 10:20:18 PM PST by Billthedrill
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To: Coleus
i bet that once the drug companies take out the mercury and make the MMR vaccine into 3 separate vaccines, you will see many of the anti-vaccine people come around.


I bet that once people stop spreading rumors that MMR vaccine contains mercury, the anti-vaccine people will come around. MMR vaccine does NOT contain mercury. (on second thought, they probably won't)

Thimerosal was used to prevent contamination in multi-dose vials (to the best of my knowledge, the only vaccine that currently contains Thimerosal is the ADULT flu vaccine). I have personally given at least hundreds of doses of the MMR vaccine since 1994, and the vaccine has always been in 2 separate single-dose vials (the 1 vial is sterile water, the other is the powdered form of the vaccine). If you look at the prescribing info, you will see that Thimerosal is NOT an ingredient.

In addition, the MMR and mercury "theories" on autism seemed to have merged. From what I gather, though, these are 2 separate theories.

Andrew Wakefield proposes a theory that by giving the measles and mumps vaccine together, there is a risk due to a poorly understood reaction that causes damage to the intestines ("autistic bowel").This was based on a study of 12 autistic children with "severe bowel conditions". That's pretty weak. If the study involved hundreds of autistic children over a period of years, you  may be able to have some hope that the theory is correct, but a study of 12?

As for the link between mercury and autism, read this.

23 posted on 03/29/2006 3:44:37 AM PST by Born Conservative (Chronic Positivity - http://jsher.livejournal.com/)
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To: Incorrigible
Cautiously sounds good to me. My bod is a toxic sewer when it comes to prescribed medications right now. But I'll keep my eyes on this one.


This is a ch__ch. What's missing?

24 posted on 03/29/2006 3:50:24 AM PST by rdb3 (What it is is what it was.)
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To: Born Conservative
MMR vaccine does NOT contain mercury. >>

I didn't say that, let me rephrase.

Most of the anti vaccine people will turn around if the drug companies and the medical professsion do 2 of the following:

1. Make the MMR into 3 separate vaccines: one vaccine for measles, one for mumps and one for rubella all given at separate times.

2. Remove mercury from vaccines.

(to the best of my knowledge, the only vaccine that currently contains Thimerosal is the ADULT flu vaccine). >>>

that's today, after: the the long fight, some pressure from congress and from pediatricians who follow the DAN protocol. From what I understand thimerosal is no longer used anymore in childhood vaccines, the consumer and political pressure envoked a change.
25 posted on 03/29/2006 10:15:26 AM PST by Coleus (STOPP Planned Parenthood http://www.freerepublic.com/focus/f-news/892053/posts)
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To: Coleus

Thanks for clarifying.

As for separate vaccines, I don't think that will happen anytime soon; there is minimal, if any scientific evidence to support that. My theory on multiple vaccines: everyday, our immune system is literally bombarded by thousands of microorganisms. Therefore, I don't think that giving multiple antigens will have any adverse effect.

I agree that the reason that Thimerosal was removed after political pressure, and indirectly, to consumer pressure. It's interesting to note that most of the vaccines were mercury-free by the end of the 20th century, yet autism rates continue to climb.


26 posted on 03/29/2006 11:39:43 AM PST by Born Conservative (Chronic Positivity - http://jsher.livejournal.com/)
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To: Born Conservative
I don't know why they are giving children hepatitis B shots. It's a disease usually contracted sexually and through sharing needles.

Back in the 60's most of us lived through the measles, mumps and the chicken pocks. As a matter of fact, when one of us contracted the disease, the doctor told our parents to let us all sleep in the same room, get the disease and be done with it all at once.
27 posted on 03/29/2006 11:47:35 AM PST by Coleus (STOPP Planned Parenthood http://www.freerepublic.com/focus/f-news/892053/posts)
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To: Coleus

You can probably tell that I'm pro-vaccine, but I agree about Hep B; why are we doing mass vaccinations of children? I can see MAYBE giving it pre-adolescence, but to babies? And now, they are going to start giving Hepatitis A; neither are common childhood diseases.

Yes, we did live through measles, mumps, and chicken pox, but measles can cause deafness and meningitis. Chicken pox vaccine-it's effective in 80% of kids who receive it, and the other 20% who get the disease even though they were vaccinated, will have a much milder case of it. There aren't too many healthy kids who get chicken pox and have bad outcomes, but it does help people with suppressed immune systems to cut down on the incidence of the disease.


28 posted on 03/29/2006 5:57:42 PM PST by Born Conservative (Chronic Positivity - http://jsher.livejournal.com/)
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