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Red Wine Ingredient Increases Endurance, Study Shows
NY Times via boston.com ^ | November 17, 2006 | Nicholas Wade

Posted on 11/24/2006 9:05:06 PM PST by neverdem

A drug already shown to reverse the effects of obesity in mice and make them live longer has now been shown to increase their endurance as well.

Experts say the finding may open up a new field of research on similar drugs that may be relevant to the prevention of diabetes and other diseases.

An ordinary laboratory mouse will run one kilometer on a treadmill before collapsing from exhaustion. But mice given resveratrol, a minor component of red wine and other foods, run twice as far. They also have energy-charged muscles and a reduced heart rate, just as trained athletes do, according to an article published online in Cell by Johan Auwerx and colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France.

“Resveratrol makes you look like a trained athlete without the training,” Dr. Auwerx (pronounced OH-wer-ix) said in an interview.

He and his colleagues said the same mechanism seemed likely to operate in humans, based on analysis in a group of Finnish subjects of the gene that is influenced by the drug.

Their rationale for testing resveratrol was evidence obtained three years ago that it could initiate a genetic mechanism known to protect mice against the degenerative diseases of aging and prolong their life spans by 30 percent.

Dr. Auwerx, whose interest is in the genetic control of metabolism, decided to see whether resveratrol would offset the effects of a high-fat diet, specifically the disturbances known as metabolic syndrome that are the precursors of diabetes and obesity. In his report, he and his colleagues say very large doses of resveratrol protected mice from weight gain and developing the syndrome.

Dr. Auwerx attributes this in large part to the significantly increased number of mitochondria he detected in the muscle cells of treated mice.

Mitochondria are...

(Excerpt) Read more at boston.com ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: health; medicine; oenology; resveratrol; wine

1 posted on 11/24/2006 9:05:08 PM PST by neverdem
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To: neverdem
Already posted:

http://www.freerepublic.com/focus/f-news/1730163/posts

2 posted on 11/24/2006 9:06:58 PM PST by Plutarch (To GWB: OBL >> GOP.)
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To: neverdem

Does this mean Olympic athletes are just a bunch of winos?


3 posted on 11/24/2006 9:14:30 PM PST by Man50D (Fair Tax , you earn it , you keep it!)
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To: neverdem

Sounds like I'll have to take my Ciallis with red wine.


4 posted on 11/24/2006 9:15:59 PM PST by Cobra64 (Why is the War on Terror being managed by the DEFENSE Department?)
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To: neverdem

Guess I'll try some red wine....I need more endurance...


5 posted on 11/24/2006 9:16:59 PM PST by Ernest_at_the_Beach (History is soon Forgotten,)
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To: Man50D

Bump


6 posted on 11/24/2006 9:18:08 PM PST by dcwusmc (The government is supposed to fit the Constitution, NOT the Constitution fit the government!)
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To: neverdem

but it giffs me more edurance ossifer...


7 posted on 11/24/2006 9:23:06 PM PST by kinoxi
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To: neverdem

It's also been reported a beer per day is good for the heart. That means if I drink a six pack I'll be good for almost one week!


8 posted on 11/24/2006 9:26:25 PM PST by Man50D (Fair Tax , you earn it , you keep it!)
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To: Man50D

And you guessed it only now?


9 posted on 11/24/2006 9:30:23 PM PST by GSlob
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To: Plutarch
Already posted:

http://www.freerepublic.com/focus/f-news/1730163/posts

Substance in Red Wine Could Extend Life, Study Says

I posted that too, but this is physical endurance as in running, not longevity.

10 posted on 11/24/2006 9:31:57 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: Man50D

Go distilled spirits. I read it somewhere that when they were autopsying the deceased heavy duty alcoholics, their arteries were as clean as those of babies [do not ask about the livers]


11 posted on 11/24/2006 9:32:42 PM PST by GSlob
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To: GSlob
And you guessed it only now?

I would have figured it out sooner but I drank too much beer and wine.
12 posted on 11/24/2006 9:35:03 PM PST by Man50D (Fair Tax , you earn it , you keep it!)
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To: neverdem

IIRC, the merck Index contains the reference to resveratrol synthesis - it is a rather simple molecule, not too hard to make.


13 posted on 11/24/2006 9:40:27 PM PST by GSlob
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To: Plutarch; neverdem

That is NOT the same article.

They are both about resveratrol, but discuss two different studies.

Read, before you jump to conclusions.


14 posted on 11/24/2006 9:45:02 PM PST by FairOpinion
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To: Clemenza; rmlew; PARodrig; martin_fierro

ping


15 posted on 11/24/2006 9:50:50 PM PST by Cacique (quos Deus vult perdere, prius dementat ( Islamia Delenda Est ))
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To: GSlob
Go distilled spirits. I read it somewhere that when they were autopsying the deceased heavy duty alcoholics, their arteries were as clean as those of babies [do not ask about the livers]

Sounds good. I don't want to go through an artery transplant.

16 posted on 11/24/2006 10:00:34 PM PST by Erasmus (I finally figured out that my life has a purpose--as a cautionary example to others.)
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To: Cacique; Clemenza; rmlew; PARodrig
Red Wine Ingredient Increases Endurance, Study Shows

I'm set to go all night.

17 posted on 11/24/2006 10:02:07 PM PST by martin_fierro (< |:)~)
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To: neverdem

If someone put me on a thread mill and made me run until I collapsed in exhaustion, I would probably loose weight too.


18 posted on 11/24/2006 10:05:33 PM PST by CindyDawg
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To: neverdem

Bottom line....drink wine....don't be a Rat!


19 posted on 11/24/2006 10:11:57 PM PST by TheLion
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To: Ernest_at_the_Beach
Guess I'll try some red wine....I need more endurance...

The amount they're giving to the test mice in these resveratrol experiments equates to a lot more for people than can be found in a few glasses of red wine. If humans can achieve similar results, it'll have to be with pills at a much higher dosage. Meantime I'm going by the health food store and see if they have resveratrol pills. By the time experiments lead to clinical trials lead to FDA approval in 50 years or so, I'll probably be dead of old age.
20 posted on 11/24/2006 10:56:02 PM PST by AnotherUnixGeek
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To: neverdem

My wife is diabetic, we didn't drink, my wife controls her blood sugar through diet rather than drugs, lately her blood sugar was creping up in the mornings, she has started having a glass of wine with dinner and it has help her blood sugar.


21 posted on 11/24/2006 11:04:17 PM PST by Leto
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To: TheLion

Somebody's really pushing the wine drinking stuff lately! Could it be the wine industry?

But - for those that cannot drink alcohol for one reason or another - you still get resveratrol in Bilberry supplements - which has been used in the same problems of diabetes, eye ailments, cataracts, diabetic retinopathy, high blood pressure, macular degeneration, and sickle cell anemia - just to mention a few things.

Do a Google search on resveratrol and you will find it says: Resveratrol was found in varying amounts in bilberry.

You can also get bilberry from grape skins - which is also in supplements - a safer source for some people.


22 posted on 11/24/2006 11:04:48 PM PST by Anita1 ((In support of the troops, but opposed to the war means - you don't believe in what they are doing!))
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To: Anita1
You can also get bilberry from grape skins.

Perhaps flavinoids and anthocyanidins, but the bilberry is related to blueberries and cranberries.

Bilberry

23 posted on 11/25/2006 12:26:47 AM PST by Sarajevo
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To: Cobra64

Yep. Bacchus and Venus go side by side.


24 posted on 11/25/2006 2:02:23 AM PST by GSlob
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To: AnotherUnixGeek

From the higher resveratrol dose [similar to what was given to the research mice] you might grow a mouse tail, or even [god forbid!] become a RAT.


25 posted on 11/25/2006 2:05:24 AM PST by GSlob
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To: neverdem

I remember being a tourist in the Alps and going on a hike with this French tour guide named Manuel. We Americans were gasping and panting and falling behind him in the thin oxygen of the mountains, and he was just striding along, smoking cigarettes and drinking red wine out of his flask. Every so often, he'd turn, notice that half the group had collapsed about a quarter mile back, and say, "Oh... We take a break now, yes?


26 posted on 11/25/2006 3:11:25 AM PST by A_perfect_lady
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To: Leto
My wife is diabetic, we didn't drink, my wife controls her blood sugar through diet rather than drugs, lately her blood sugar was creping up in the mornings, she has started having a glass of wine with dinner and it has help her blood sugar.

Beware about your wife being prescribed a sulfonylurea, e.g. Diabeta, Micronase, etc., in the future. Alcohol and sulfonylureas don't mix.

27 posted on 11/25/2006 2:25:26 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: Sarajevo

Bilberry is a rich source of quercetin, a bioflavonoid that helps strengthen capillaries. Studies have shown that quercetin and other flavonoids modify anti-inflammatory responses, prevent LDL oxidation and platelet aggregation, and promote the relaxation of cardiovascular smooth muscle. These actions may help to prevent cardiovascular conditions such as atherosclerosis, hypertension, and arrhythmia...

Moreover, the berries from this low-growing deciduous shrub native to northern Europe are packed with Resveratrol, a natural antioxidant with anti-inflammatory, anti-tumorigenic, and immunomodulatory actions. Resveratrol is both chemopreventive and chemotherapeutic...

http://216.239.51.104/search?q=cache:o5nQjX2-CVMJ:www.lef.org/magazine/mag2006/nov2006_aas_01.htm+resveratrol+in+Bilberry&hl=en&gl=us&ct=clnk&cd=1


28 posted on 11/26/2006 1:32:20 AM PST by Anita1 ((In support of the troops, but opposed to the war means - you don't believe in what they are doing!))
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To: neverdem

All this time I've been drinkin' the white stuff. I coulda been a contendah...


29 posted on 11/26/2006 1:39:52 AM PST by TADSLOS (Mohammed was the L. Ron Hubbard of his time.)
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