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A Dose of Worms, Please (multiple sclerosis head's up!)
ScienceNOW Daily News ^ | 17 January 2007 | Dan Ferber

Posted on 01/20/2007 9:56:21 PM PST by neverdem

A prolonged bout of intestinal parasites seems to slow the decline of patients with multiple sclerosis, according to a study released today. The results suggest that immune-modulating molecules from parasites could be developed into drugs to ease autoimmune diseases, and that by conquering parasite infections, modern medicine may have inadvertently increased our vulnerability to these illnesses.

Autoimmune diseases such as multiple sclerosis (MS) occur far more often in developed countries than in developing countries. And parasitic infections, which have been beaten down in the United States, are still common in South America and elsewhere in the developing world, says neuroimmunologist Jorge Correale of the Raúl Carrea Institute for Neurological Research in Buenos Aires, Argentina. What's more, studies have shown that infecting mice with parasites eased symptoms of an MS-like syndrome.

To see if the parasite-autoimmune link held up in humans, Correale and his colleague Maurício Farez identified 12 MS patients with high levels of parasite-fighting white blood cells called eosinophils and then confirmed parasite infections by examining stool samples under the microscope. They tracked those patients and equal numbers of uninfected MS patients and healthy people for 4 and a half years. In MS, the immune system attacks the insulating myelin sheath of nerves, disrupting the transmission of messages. Infected patients as a group suffered just three instances of new or worsening symptoms, compared with 56 in the uninfected patients. As measured by a standard neurological test, the degree of disability increased in 11 of the 12 uninfected patients, but in only two of the 12 infected individuals.

Next, the team measured white blood cells and immune-signaling chemicals called cytokines from each patient to understand how the invaders changed the immune system. Parasite infections induced much higher levels of three types of immune cells called regulatory T cells, the researchers report in January 2007 issue of Annals of Neurology. They propose that while fighting the parasite infection, these three types of cells also happen to dial down a different arm of the immune system that attacks myelin to cause multiple sclerosis. By finding the immune-signaling molecules responsible, it may one day be possible to identify parasite molecules that deactivate the immune system arm that causes autoimmune attacks, Correale says.

"It's a provocative study, and it would be interesting to do this in a larger number of individuals," says immunologist David Hafler of Harvard Medical School. If the results hold up, he says, it would underscore the emerging consensus that "an idle immune system is probably not good."

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TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: eosinophilia; intestinalparasites; medicine; ms; multiplesclerosis
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Association between parasite infection and immune responses in multiple sclerosis.
1 posted on 01/20/2007 9:56:23 PM PST by neverdem
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To: neverdem
Parasitic association with immune response in Croh's Disease www.webmd.com/content/Article/87/99477.htm
2 posted on 01/20/2007 10:16:08 PM PST by Jeff Chandler ("... without victory there is no survival." - Winston Churchill)
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To: Jeff Chandler

Crohn's


3 posted on 01/20/2007 10:16:21 PM PST by Jeff Chandler ("... without victory there is no survival." - Winston Churchill)
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To: neverdem; JockoManning

PING


4 posted on 01/20/2007 10:27:37 PM PST by Quix (LET GOD ARISE AND HIS ENEMIES BE SCATTERED. LET ISRAEL CALL ON GOD AS THEIRS! & ISLAM FLUSH ITSELF)
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To: neverdem; cgk
Interesting...


5 posted on 01/20/2007 10:35:42 PM PST by rdb3 (But the riot inside moves on...)
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To: rdb3; cgk

Now I know what to get my wife for her birthday. Parsites!

BTW, nice to see you rdb3. Haven't bumped into you in a long while.


6 posted on 01/20/2007 10:43:24 PM PST by Incorrigible (If I lead, follow me; If I pause, push me; If I retreat, kill me.)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
I'm going to start a convention here. When I make a link to a thread, and I made a link to a professional abstract, or I see some real fascinating stuff, I'll indicate it after the link by a number within parentheses, e.g. (12) which indicates the comment number on that thread to find it.

Scientific breakthrough: Danish researchers find possible schizophrenia cause (12)

It's Not So Bad To Be Fat (25)

Concern as revived 1918 flu virus kills monkeys

FReepmail me if you want on or off my health and science ping list.

7 posted on 01/20/2007 10:44:58 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: Jeff Chandler

Thanks for the link.


8 posted on 01/20/2007 10:45:51 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem; Jim Robinson

PING


9 posted on 01/20/2007 10:48:13 PM PST by Quix (LET GOD ARISE AND HIS ENEMIES BE SCATTERED. LET ISRAEL CALL ON GOD AS THEIRS! & ISLAM FLUSH ITSELF)
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To: neverdem

I sent the article link to my sister who has MS.

I doubt she will be running out to get a gut full of worms though.


10 posted on 01/20/2007 10:56:27 PM PST by Chewbacca (I reject your reality and substitute my own.)
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To: Incorrigible
How you be, Incorrigible? It has been a minute.

I'm still around, just in the shadows.


11 posted on 01/20/2007 11:02:31 PM PST by rdb3 (But the riot inside moves on...)
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To: Jeff Chandler; All
Helminths and mucosal immune modulation.

Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation.

Enter Weinstock jv at PubMed. Lower case is accepted. You've just done a chronological author search for the guy mentioned in your link. Look at the rectangles just to the left of each title. If it has just lines, all you get is an abstract. If it has a green or orange bars, you can link the free article.

12 posted on 01/20/2007 11:18:26 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: Chewbacca

http://clinicaltrials.gov/ct/gui


13 posted on 01/20/2007 11:23:06 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem; All
Here's where you get the worms for Crohn's: http://www.ovamed.de/english/home/home.html
14 posted on 01/20/2007 11:30:11 PM PST by Jeff Chandler ("... without victory there is no survival." - Winston Churchill)
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To: neverdem

reminder bump for am - thanks. :-)


15 posted on 01/20/2007 11:54:55 PM PST by Tunehead54 (Nothing funny here ;-)
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To: neverdem

Same seems to happen with asthma.

Sometimes I think we have sterilized our world to the point that our bodies can't deal with it....


16 posted on 01/21/2007 12:02:03 AM PST by Gamecock (Ecclesia reformata, semper reformanda secundum verbum Dei)
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To: Jeff Chandler

Diet of worms protects against bowel cancer

REGULAR doses of worms really do rid people of inflammatory bowel disease. The first trials of the treatment have been a success, and a drinkable concoction containing thousands of pig whipworm eggs could soon be launched in Europe.
The product will be called TSO, short for Trichuris suis ova, and will be made by a new German company called BioCure, whose sister company BioMonde sells leeches and maggots for treating wounds. Chief executive Detlev Goj says he expects sales of TSO in Europe will start in May, after approval by the European Agency for the Evaluation of Medicinal Products. The agency would not comment. The pig whipworm was chosen as it does not survive very long in people. Patients would have to take TSO around twice a month. The human whipworm, which infects half a billion people, can occasionally cause problems such as anaemia.

The latest trials, carried out in the US, involved 100 people with ulcerative colitis and 100 with Crohn's disease, both incurable and potentially serious diseases collectively known as inflammatory bowel disease. In many of the volunteers the symptoms of IBD- such as abdominal pain, bleeding and diarrhoea- disappeared. The remission rate was 50 per cent for ulcerative colitis and 70 per cent for Crohn's, says gastroenterologist Joel Weinstock of the University of Iowa, who devised the treatment.

~SNIP~

http://www.eurekalert.org/pub_releases/2004-04/ns-dow040704.php


17 posted on 01/21/2007 12:20:29 AM PST by stlnative
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To: neverdem

Interesting ... I was diagnosed with MS 12 years ago. About 6 years back I was bitten by a tick. I started feeling really tired and awful and feverish. The only thing my doctor could find was VERY high levels of eosinophils ... he was worried it might be cancer, and sent me to a hematologist. They found nothing.

After 2 months of antibiotics (levaquin), I felt better, but the eosinophil level never got quite all the way down. Before then I was having 3-4 MAJOR exacerbations per year ... solu-medrol ... the whole bit ... and I was on Beta-Seron, then Avonex.

After that bout of eosinophilia, I've had one very, very minor MS attack (I'm not even sure it was one it was so mild ... maybe a flare of old symptoms?). I was never tested for intestinal parasites, but don't they cause other symptoms? Interesting.


18 posted on 01/21/2007 12:22:23 AM PST by lkco
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To: lkco
I was never tested for intestinal parasites, but don't they cause other symptoms? Interesting.

Yes they can cause other symptoms, but maybe you haven't become symptomatic yet. I would get my stool checked for ova and parasites.

19 posted on 01/21/2007 12:37:10 AM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem

I just emailed a friend that works in a research lab to see if she can get me a copy of the full article from the Annals of Neurology. I don't mind getting tested, but frankly I want to find out what kind they are so I can figure out what their favorite foods are :).

If I've had them for 6 years, they can't be all bad. The article (I've read a few dumbed-down versions in the last hour now) says they're common in some parts of the world, so they can't be too harmful or cause too many symptoms. Maybe their favorite food is chocolate?


20 posted on 01/21/2007 1:20:22 AM PST by lkco
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To: lkco

If they can't get it, ask someone with access to a medical library, e.g. a doc with hospital privileges.


21 posted on 01/21/2007 1:40:21 AM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem

Parasites can be found in abundance in blue states.


22 posted on 01/21/2007 1:45:15 AM PST by Stallone (War and Politics: When the Enemy begins to feel pain, they change their behavior to avoid it.)
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To: ImaTexan

ping


23 posted on 01/21/2007 1:48:19 AM PST by bjcintennessee (Don't Sweat the Small Stuff)
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To: neverdem

Interesting as it meshes with bee venom therapy for MS. The same thing happens with a slowing of the progression of the disease and bee venom also kicks up the immune system. In essence, both treatments are counterintuitive, sine it would seem that you would want to suppress the immune system, not kick it up with an auto-immune disease.


24 posted on 01/21/2007 3:35:27 AM PST by KeyWest (Help stamp out taglines!)
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To: neverdem

My wife has MS and I let her read this. I hope it leads to a treatment.

Okay, part of me was trying to gross her out, too.


25 posted on 01/21/2007 6:01:38 AM PST by Puddleglum
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To: neverdem

very grateful to be on your ping list


26 posted on 01/21/2007 6:25:43 AM PST by 1234 (WHO is Responsible for ENFORCING IMMIGRATION LAWS?)
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To: neverdem
Rather than using parasites to reduce inflammation, one should consider eating lots of Omega-3s while reducing Omega-6s.
27 posted on 01/21/2007 7:35:06 AM PST by ConservativeMind
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To: neverdem; 2ndClassCitizen; balls; Born Conservative; cva66snipe; dawn53; Deut28; Draco; dredhawk; ..

MS Ping!

Please FReepmail me if you would like to be added to, or removed from, the Multiple Sclerosis ping list...

28 posted on 01/21/2007 8:41:54 AM PST by cgk (I don't see myself as a conservative. I see myself as a religious, right-wing, wacko extremist.)
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To: Incorrigible; rdb3

Thanks for the pings! I haven't read this yet, as I'd like some time to *REALLY* process what it's saying, but already I'm kind of --- hmm... uhm... ewwww!


29 posted on 01/21/2007 8:43:29 AM PST by cgk (I don't see myself as a conservative. I see myself as a religious, right-wing, wacko extremist.)
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To: neverdem; xsmommy; Gabz; WhyisaTexasgirlinPA; secret garden; tioga; theDentist
Yet today's nanny-state (mothers and power-hungry politicians/bureaucrats/day-care regulators and schools) are DEMANDING an ever-increasing level of sanitation: Anti-bacterial soaps will be working AGAINST the long-term health of the kids.
30 posted on 01/21/2007 8:55:40 AM PST by Robert A. Cook, PE (I can only donate monthly, but Hillary's ABBCNNBCBS continue to lie every day!)
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To: Chewbacca; All
I sent the article link to my sister who has MS.

Better yet, send her the link to www.marshallprotocol.com. There's a cure waiting. It worked for my sarcoid, and is being used for several MS patients by Dr Doug Blaney.

31 posted on 01/21/2007 8:56:12 AM PST by slowhandluke (It's hard work to be cynical enough in this age)
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To: Puddleglum
My wife has MS and I let her read this. I hope it leads to a treatment.

Point her to www.marshallprotocol.com. There's a cure waiting. It worked for my sarcoid, and is being used for several MS patients by Dr Doug Blaney. I'm sure Dr Blaney is willing to discuss current progress with your doc.

32 posted on 01/21/2007 8:59:11 AM PST by slowhandluke (It's hard work to be cynical enough in this age)
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To: Robert A. Cook, PE; neverdem

I totally agree, Rob't. Clean is one thing, total sanitization of everything is something else.

My ex-husband passed away last year because of complications of MS. The man was an absolute fanatic when it came to cleaning....he bleached EVERTYHING.


33 posted on 01/21/2007 9:21:09 AM PST by Gabz (I like mine with lettuce and tomato, heinz57 and french-fried potatoes)
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To: neverdem

I've recently been diagnosed with RRMS... thanks so much for the information/links.


34 posted on 01/21/2007 9:45:35 AM PST by Sweet_Sunflower29 (Interferon Beta 1-b is my new best friend. <><)
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To: neverdem

bttt


35 posted on 01/21/2007 10:16:40 AM PST by Smokin' Joe (How often God must weep at humans' folly.)
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To: neverdem

Thanks for the ping. I read the article a few days ago. Somebody had posted it on an MS forum. I have a sister who lives in Central America. Maybe I she visit her in hopes of picking up a parasite!


36 posted on 01/21/2007 11:04:43 AM PST by dawn53
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To: Puddleglum

My wife has MS, I never realized how much she meant to me until she was diagnosed. I now cherish every day we have.


37 posted on 01/21/2007 11:14:33 AM PST by 2ndClassCitizen
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To: ConservativeMind

Any basis for this recommendation? references?


38 posted on 01/21/2007 11:24:32 AM PST by 2ndClassCitizen
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To: slowhandluke

I had sarcoidosis when I was twenty five. It went away on its own. I did take 100 times the minimum daily requirement for vitamin c for several months (lots of water also).


39 posted on 01/21/2007 11:26:56 AM PST by 2ndClassCitizen
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To: dawn53

This reminds me of a kid I knew who was allergic to beestings. He wanted to get out of being drafted and sent to Vietnam. He got a bee just before going to the doctor and held it in his hand until it stung him. It really hurt, but he no longer had an allergy.

I think this study and so many others offer real hope. We are going to beat MS, just got to keep optimistic.


40 posted on 01/21/2007 11:30:05 AM PST by 2ndClassCitizen
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To: 1234

"very grateful to be on your ping list"

You're added, but I almost missed your request. That's why I recommended FReepmail requests. Adios


41 posted on 01/21/2007 11:42:43 AM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem

Thanks Neverdem.

Actually she actually emailed me back already with other articles by this author. This new one isn't available on PubMed yet ... it's not even on the Annals of Neurology site yet ... where it's supposed to be published already. It should be there by the end of the week.

I'll summarize and post once I get the full article. The abstract doesn't say much more than the "for public consumption" ones did.


42 posted on 01/21/2007 11:51:13 AM PST by lkco
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To: neverdem

Oh, and please add me to the ping list.

Freepmail coming.


43 posted on 01/21/2007 11:53:27 AM PST by lkco
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To: 2ndClassCitizen
I had sarcoidosis when I was twenty five. It went away on its own. I did take 100 times the minimum daily requirement for vitamin c for several months (lots of water also).

You were lucky. The recent NIH Access study did not did not find any remissions longer than 2 years.

44 posted on 01/21/2007 12:29:58 PM PST by slowhandluke (It's hard work to be cynical enough in this age)
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To: 2ndClassCitizen

I am a huge fan of Vitamin C that one would think I sell the stuff or own stock in a company making it. It's worked miracles for my rheumatoid arthritis and other problems. I've been reading a lot about intravenous Vit C, too. Wish I knew of someone to administer it, if I ever need it.


45 posted on 01/21/2007 12:32:02 PM PST by Conservativegreatgrandma
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To: Robert A. Cook, PE
Good luck sanitizing the world. That dang stuff drys out the skin on my hands. I use plain old soap and water whenever I can. I never put that antibacterial alcohol saturated lotion on.
46 posted on 01/21/2007 12:32:19 PM PST by tioga
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To: neverdem

Know someone that has MS with many exacerbations a year of varying degrees in intensity, since they've been on a low dose of cozaar (25 mg daily) not one exacerbation in over two years... lots of stress and mitigating circumstances to warrant an exacerbation but not one, a bit of weakness from time to time but nothing that required medical intervention. The doc said that it wouldn't hurt, so let's try it, and they did.


47 posted on 01/21/2007 12:38:12 PM PST by WellsFargo94 ("All that is necessary for evil to succeed is for good men to do nothing.")
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To: cgk

Oh yuck! A gut full of worms sounds nasty but it would be nice if these parasites can someday lead to a cure.


48 posted on 01/21/2007 1:07:04 PM PST by octobersky
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To: WellsFargo94
Know someone that has MS with many exacerbations a year of varying degrees in intensity, since they've been on a low dose of cozaar (25 mg daily) not one exacerbation in over two years... lots of stress and mitigating circumstances to warrant an exacerbation but not one, a bit of weakness from time to time but nothing that required medical intervention.

Was blood pressure checked when the person complained of feeling weakness? BTW, I couldn't find anything reported about cozaar and MS. Maybe something else has done it, e.g. meds, bee sting or parasites, etc.?

49 posted on 01/21/2007 1:50:40 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: lkco
I'll summarize and post once I get the full article. The abstract doesn't say much more than the "for public consumption" ones did.

IMHO, a well written abstract is enough to make the take home point and satisfy my curiosity. Otherwise, the stuff in a whole article gets dense on time consuming details, usually only good for arguing those particular details or having its references, although it's nice to have.

50 posted on 01/21/2007 1:51:33 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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