I do not avoid women, Mandrake...
Posted on 09/19/2007 7:07:34 PM PDT by neverdem
Tracking down powerful adult stem cells in mouse testes may benefit humans, too
Researchers say they have found a way to pluck out a potent type of stem cell from the testes of adult mice and transform it into other kinds of tissue, including heart muscle and blood vessels.
The result—the second such finding in the past year—suggests that similar cells from human testicles might have similar powers, paving the way to creating replacement tissue for men who have suffered damage from heart attacks or other injuries and avoiding some of the controversy surrounding embryonic stem cells (ESC).
Three separate groups reported in June that they had reprogrammed adult mouse skin cells into a form nearly indistinguishable from ESCs. But researchers still have to figure out how to prevent those cells from causing cancer.
Women already have a source of custom stem cells (in principle) in the form of parthenogenesis embryos grown without sperm.
To give men their fair shake, Shahin Rafii, professor of genetic medicine at Weill Cornell Medical College in New York City, along with Memorial Sloan-Kettering Cancer Center medical oncologist Marco Seandel and their colleagues homed in on a specific group of mouse spermatogonial progenitors—stemlike cells that give rise to cellular sperm factories called spermatogonia.
Normally, adult stem cells can only morph into the type of tissue in which they reside, such as blood, brain or muscle. Rafii says, however, that cells giving rise to sperm—and, therefore, embryos—should have the same developmental potential as sperm do. He notes that testicular and ovarian cancers often produce teratomas, noninvasive tumors made up of tissues from all three embryonic layers.
The group first extracted and purified progenitor cells bearing a protein molecule called GPR125. When transplanted back into the mouse testis, they produced spermatogonia as expected.
The team then cultured the cells for several months in a bath of growth-promoting proteins, trying to get the cells to reverse course and become more like stem cells. When they injected the tissue into growing mouse embryos, the cells formed teratomas like ESCs do, and mingled with the blood vessels of the mice, the group reports in this week in Nature.
Other groups reprogrammed mouse skin cells by inserting four embryonic genes, some of which are oncogenes (genes that promote cancer). "To me the therapeutic potential of this is much more tremendous than to reprogram a skin cell with four oncogenes," Rafii says. "We reprogram without genetic tweaking."
The challenge, he says, will be figuring out how to force the transition from progenitors to stem cells, which spontaneously occurred in about one third of testicular cell lines.
Scientists in Germany last year reported that they could transform adult mouse spermatogonial progenitors into cells genetically resembling ESCs by using a different growth medium for just a few weeks. Without a marker, however, "they have no clue where their cells came from," Rafii says.
Better markers would be valuable for purifying and studying cells, says molecular geneticist Takashi Shinohara of Kyoto University in Japan, who led a group that in 2004 discovered cells similar to ESCs from newborn mouse testes. But he is skeptical about the newer studies, which are yet to be confirmed by other labs.
Others are more upbeat, but agree more research is needed. "The studies seem carefully done to me," says stem cell biologist Sean Morrison of the University of Michigan Medical School. "I suspect a lot of people are watching to see if the results will fully hold up or whether it will turn out to be only partially true."
SC ping
” human testicles might have similar powers”
Never mind, it’s just too easy.
Something about “vital bodily fluids” in this.
I do not avoid women, Mandrake...
Mouse balls are now available as FRU (Field Replacement Unit). Therefore, if a mouse fails to operate or should it perform erratically, it may need a ball replacement. Because of the delicate nature of this procedure, replacement of mouse balls should only be attempted by properly trained personnel.
Before proceeding, determine the type of mouse balls by examining the underside of the mouse. Domestic balls will be larger and harder than foreign balls. Ball removal procedures differ depending upon the manufacturer of the mouse. Foreign balls can be replaced using the pop-off method. Domestic balls are replaced by using the twist-off method. Mouse balls are not usually static sensitive. However, excessive handling can result in sudden discharge.
Upon completion of ball replacement, the mouse may be used immediately. It is recommended that each replacer have a pair of spare balls for maintaining optimum customer satisfaction. Any customer missing his balls should suspect local personnel of removing these necessary items."
I like where this thread is going.
Looks like the survivors of the explosion at the Sta-Puft factory.
Mice Testicles Yield 'Ethical' Stem Cells
Testicles May Provide A Better Kind Of Stem Cell
Key To Future Stem Cell Production May Lie Inside The Testicles
Mouse Testicle Cells Behave Like Stem Cells, Suggesting New Source For Therapy
Testes To Incubate Stem CellsTreating male infertility with stem cells
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One of the greatest movies ever!
Fascinating. I had no idea that stem cells had balls.
Oh, come on!
Every man usually has two. Why would you even miss one?
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