Posted on 10/18/2007 4:22:21 PM PDT by neverdem
The worlds most promising malaria vaccine has been shown to work in infants less than a year old, the most vulnerable group, according to a study being published today.
The study, being published in The Lancet, a British medical journal, was small, comprising only 214 babies in Mozambique, and intended to show only that the vaccine was safe at such young ages. But it also indicated that the risk of catching malaria was reduced by 65 percent after the full course of three shots.
Were now a step closer to the realization of a vaccine that can protect African infants, said Dr. Pedro Alonso, the University of Barcelona professor who leads clinical trials of the GlaxoSmithKline vaccine.
If it passes much larger clinical trials set to start in seven countries next year, and if it is accepted by national regulatory agencies, it could be ready for distribution by 2012, said Dr. W. Ripley Ballou, Glaxos vice president for international clinical trials.
In 2004, Dr. Alonso showed for the first time that the vaccine could protect children against infection or death. That study of 2,022 children aged 1 to 4 showed protection from infection about 45 percent of the time.
Such a relatively low level of protection would not be acceptable in a vaccine in the West, but malaria is a leading killer of African children, so even imperfect coverage is a major public health victory.
The vaccine, presently known as RTS,S and tentatively brand-named Mosquirix, is made by fusing a bit of outer protein of the deadly falciparum strain of the malaria parasite with a bit of hepatitis B virus and a chemical booster the latter two added to provoke a stronger immune reaction.
At least nine malaria vaccine candidates are in development, but Mosquirix is the furthest along...
(Excerpt) Read more at nytimes.com ...
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Huh, interesting.
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