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Novel non-antibiotic agents against MRSA and common strep infections
Biology News Net ^ | September 12, 2012 | NA

Posted on 09/21/2012 5:25:12 PM PDT by neverdem

Menachem Shoham, PhD, associate professor of biochemistry at Case Western Reserve University School of Medicine, has discovered novel antivirulence drugs that, without killing the bacteria, render Methicillin Resistant Staphylococcus Aureus (MRSA) and Streptococcus pyogenes, commonly referred to as strep, harmless by preventing the production of toxins that cause disease. The promising discovery was presented this week at the Interscience Conference on Antimicrobial Agents and Chemotherapy in San Francisco.

MRSA infections are a growing public health concern, causing 20,000 to 40,000 deaths per year in the United States alone. It is the most prevalent bacterial pathogen in hospital settings and in the community at large, with about one million documented infections per year nationally, costing an estimated $8 billion annually to treat.

The problem has become increasingly severe as the bacteria have developed a resistance to antibiotics. As result, health care providers are running out of options to treat patients suffering from antibiotic-resistant infections, like MRSA and strep, creating a dire need for alternative treatments and approaches.

"Staph bacteria are ubiquitous and normally do not cause infections, however, occasionally these bacteria become harmful due to their secretion of toxins," says Dr. Shoham. "We have discovered potential antivirulence drugs that block the production of toxins, thus rendering the bacteria harmless. Contrary to antibiotics, these new antivirulence drugs do not kill the bacteria. Since the survival of the bacteria is not threatened by this approach, the development of resistance, like that to antibiotics, is not anticipated to be a serious problem."

Dr. Shoham identified a bacterial protein, known as AgrA, as the key molecule responsible for turning on the release of toxins. AgrA, however, needs to be activated to induce toxin production. His goal was to block the activation of AgrA with a drug, thus preventing the cascade of toxin release into the blood that can lead to serious infections throughout the body.

The screening for AgrA inhibitors was initially carried out in a computer by docking libraries of many thousands of "drug-like" compounds and finding out which compounds would fit best into the activation site on AgrA. Subsequently, about 100 of the best scoring compounds were tested in the laboratory for inhibition of the production of a toxin that ruptures red blood cells. Seven of these compounds were found to be active. Testing compounds bearing chemical similarity to the original compounds lead to the discovery of additional and more potent so-called "lead" compounds.

Optimization of the initial "lead" compounds was performed by chemical synthesis of 250 new compounds bearing small but important chemical modifications on one of the initial leads. More than a dozen active compounds have been discovered by this method. The best drug candidate reduces red blood cell rupture by 95 percent without affecting bacterial growth.

Beginning this fall, Dr. Shoham and colleagues will begin testing the drug candidate in animal models.

"It is possible to inhibit virulence of MRSA without killing the bacteria," continues Dr. Shoham. "Such antivirulence drugs may be used for prophylaxis or therapy by themselves or in combination with an antibiotic. Antivirulence therapy may resensitize bacteria to antibiotics that have become ineffective by themselves." Source : Case Western Reserve University


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: antivirulenceagents; antivirulencedrugs; antivirulencetherapy; microbiology; mrsa; strep
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Antivirulence agents against MRSA

His paper from last year.

1 posted on 09/21/2012 5:25:20 PM PDT by neverdem
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To: neverdem

My cousin just about lost a leg to this stuff a couple of years ago ... quite an ordeal.


2 posted on 09/21/2012 5:29:20 PM PDT by MissMagnolia (Being powerful is like being a lady. If you have to tell people you are, you aren't. (M.Thatcher))
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To: neverdem

If they think they are making good progress now, wait till they try vinegar.


3 posted on 09/21/2012 5:34:45 PM PDT by whiterhino
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
The hidden threat of West Nile virus - Researchers probe possible link with kidney disease.

FReepmail me if you want on or off my combined microbiology/immunology ping list.

4 posted on 09/21/2012 5:36:58 PM PDT by neverdem ( Xin loi min oi)
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To: whiterhino

I’m glad the researchers ahven’t limited their thinking to merely topical treatments ...


5 posted on 09/21/2012 5:44:26 PM PDT by MHGinTN (Being deceived can be cured.)
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To: neverdem

Had just this past summer that landed me up in the hospital, another really bad bacterial infection, second most serious after MRSA, which if left untreated, could also become life threatening and I had it on my lower left jaw/chin area because of two dead wisdom teeth in the lower left jaw area as well called cellulitis. The wisdom teeth were removed and the area drained.


6 posted on 09/21/2012 5:48:13 PM PDT by Biggirl ("Jesus talked to us as individuals"-Jim Vicevich/Thanks JimV!)
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To: whiterhino

:’)


7 posted on 09/21/2012 5:49:34 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/)
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To: AdmSmith; AnonymousConservative; Berosus; bigheadfred; Bockscar; ColdOne; Convert from ECUSA; ...

Thanks neverdem


8 posted on 09/21/2012 5:49:50 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/)
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To: neverdem

http://www.mayoclinic.com/health/cellulitis/DS00450

About cellulitis.


9 posted on 09/21/2012 5:50:04 PM PDT by Biggirl ("Jesus talked to us as individuals"-Jim Vicevich/Thanks JimV!)
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To: neverdem

ping


10 posted on 09/21/2012 5:51:54 PM PDT by dalebert
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To: neverdem

Wonderful news! Cleveland is a pit,,, but it can be very proud of Case Western, and the work done there! My Dad graduated summa cum laude in ‘42.


11 posted on 09/21/2012 5:54:20 PM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: whiterhino

Exactly what I was thinking. Then H2O2. What are they going to do with the extra money in their budgets?


12 posted on 09/21/2012 5:56:00 PM PDT by B4Ranch (There's Two Choices... Stand Up and Be Counted ... Or Line Up and Be Numbered .)
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To: Biggirl

If you have a occurrence try drinking a tsp of baking soda in water. Raise your O2 level and kill it.


13 posted on 09/21/2012 5:58:56 PM PDT by B4Ranch (There's Two Choices... Stand Up and Be Counted ... Or Line Up and Be Numbered .)
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To: whiterhino

Dittos to that!

Several years ago, I got strep throat. My sister-in-law got it about the same time. She went to the Dr and got medicine to treat hers. I chose to gargle with cider vinegar. After two days of this, I woke up in the middle of the night to a feeling that something ‘popped’ in my throat and then feeling something slightly gritty. The sore throat was gone and I felt much better in the morning. It took my sister-in-law a week before she started to feel better.


14 posted on 09/21/2012 5:59:15 PM PDT by sneakers (Go Sheriff Joe!)
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To: Biggirl

re-occurrence


15 posted on 09/21/2012 6:00:02 PM PDT by B4Ranch (There's Two Choices... Stand Up and Be Counted ... Or Line Up and Be Numbered .)
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To: whiterhino

acetic acid, hydrogen peroxide...

how about coloidial silver?


16 posted on 09/21/2012 6:02:23 PM PDT by Mrs.Z
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To: whiterhino

“Source : Case Western Reserve University”

I worked at The University Hospitals of Cleveland for years (associated with Case.) I’d have to be at deaths door to see a doctor. There are so many cures for so many things.... If it can’t be made a pharmaceutical drug and patented, forget it. If you don’t follow alternative medicine or old treatments, tough luck. They’ve cured cancer so many different ways it’s ridiculous, but cures don’t make money for the doctors, hospitals or pharmaceutical companies, especially when they can’t be patented.


17 posted on 09/21/2012 6:05:16 PM PDT by pops88 (Standing with Breitbart for truth.)
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To: neverdem; All

Great post; great thread. Thanks to all posters.

life/health BUMP!


18 posted on 09/21/2012 6:07:33 PM PDT by PGalt
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To: neverdem

bookmark. Thanks.


19 posted on 09/21/2012 6:07:51 PM PDT by SueRae (See it? Hell, I can TASTE November from my house!)
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To: B4Ranch

Thank-you!


20 posted on 09/21/2012 6:10:18 PM PDT by Biggirl ("Jesus talked to us as individuals"-Jim Vicevich/Thanks JimV!)
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To: Mrs.Z

Silver is antimicrobial. A lot of your better athletic socks have silver in the thread to kill bacteria and prevent foot odor.

This would be considered topical, however. I don’t honestly know about ingestion, even though the antimicrobial properties of silver are well known. Seems like a little excess has sprung up around colloidal silver verging upon quackery. That doesn’t mean it has no value, but I get very cautious whenever I see much in the way seemingly of over the top claims.

Some positive reinforcement via cites from PubMed and the like would go a long way toward allaying any suspicion.


21 posted on 09/21/2012 6:12:00 PM PDT by RegulatorCountry
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To: sneakers

I use Bragg’s vinegar as it has the “mother” with live cultures. I also brew kombucha with live cultures. I swear it helped cure my urinary track infection.


22 posted on 09/21/2012 6:16:25 PM PDT by Conservativegreatgrandma
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To: neverdem

“Beginning this fall, Dr. Shoham and colleagues will begin testing the drug candidate in animal models.”

This should be interesting. Many things work in vitro that do not in vivo. Plus, sometimes the “drug” can be as bad as the infection.

Anyway, this approach would seem to show promise to me. By attacking the release of exotoxins from Staph would be a mechanism that does not currently exist in nature. Therefore, I would not expect resistance to it to develope. Generally, most antibiotic resistance is conferred by pre-existing genetic material in plasmids, etc. that already exist. They get horozontally transferred...sometimes between species.


23 posted on 09/21/2012 6:19:15 PM PDT by Sola Veritas (Trying to speak truth - not always with the best grammar or spelling)
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To: pops88
I’d have to be at deaths door to see a doctor.

Why would you go to a doctor if all these alternative cures are so great?

24 posted on 09/21/2012 6:19:56 PM PDT by Right Wing Assault (Dick Obama is more inexperienced now than he was before he was elected.)
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To: neverdem

The only known side-effect is it makes you spontaneously sing like Ethel Merman, and break wind at the same time.


25 posted on 09/21/2012 6:23:39 PM PDT by theDentist (FYBO/FUBO; qwerty ergo typo : i type, therefore i misspelll)
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To: Conservativegreatgrandma

Braggs is on my shelf, too. Wonderful for just a lift when you feel down. Sooooooo many uses!


26 posted on 09/21/2012 6:31:50 PM PDT by Exit148
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To: theDentist
is it makes you spontaneously sing like Ethel Merman, and break wind at the same time.

Heck, I do that now.

/johnny

27 posted on 09/21/2012 6:34:19 PM PDT by JRandomFreeper (Gone Galt)
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To: Dr. Bogus Pachysandra

http://www.cleveland.com/business/index.ssf/2012/09/alexander_mann_solutions_narro.html

Here’s a London-based company that just chose “the pit” for its U.S. hub. Interesting story, since they explain, “Why Cleveland?”

Republican Governor Kasich involved. Those damn Republicans bringing companies to Ohio!


28 posted on 09/21/2012 6:37:27 PM PDT by Right Wing Assault (Dick Obama is more inexperienced now than he was before he was elected.)
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To: Right Wing Assault

Case/Western Reserve. Great area during the day. But be armed at night. Of course, you can head up to Murray Hill and be completely safe!


29 posted on 09/21/2012 6:45:01 PM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: Exit148

Yes, and my favorite website for health is earthclinic.com


30 posted on 09/21/2012 6:45:33 PM PDT by Conservativegreatgrandma
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To: neverdem

Manuka honey is something else to look at.

BTW, all Jew-hating Moslems should take note that this doc is Jewish - best to keep up your boycott of things Jewish.


31 posted on 09/21/2012 6:55:29 PM PDT by Ancesthntr (Bibi to Odumbo: Its not going to happen.)
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To: Ancesthntr

Propolis : http://www.sciencedaily.com/releases/2010/06/100628111840.htm

We investigated propolis, as part of a programme aimed at discovering new antibiotics from natural sources, because bees use it as an antiseptic glue to seal gaps between honeycombs and preserve their hives from microbial contamination.

“Beeglue is also a natural remedy widely-used in folk medicine for a variety of ailments but little has been known until now about its capacity to target MRSA. Our results have been highly encouraging and we will be taking our research further to understand how active substances in propolis work and to seek the treatments which patients urgently require.”


This PDF is useful as well:

http://www.annmicro.unimi.it/full/55/kilic_55_113-117.pdf


Your local BeeKeep is your friend!


32 posted on 09/21/2012 7:15:33 PM PDT by NoNAIS (Yet another Government program not needed.)
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To: GGpaX4DumpedTea

Ping...


33 posted on 09/21/2012 7:16:28 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders.)
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To: sneakers

Sounds more like an abcess.


34 posted on 09/21/2012 7:23:35 PM PDT by skr (May God confound the enemy)
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To: JRandomFreeper

“A sad case. He thinks he’s Ethyl Merman…”


35 posted on 09/21/2012 7:25:40 PM PDT by null and void (Day 1340 of our ObamaVacation from reality - Obama, a queer and present danger)
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To: null and void
Everything's coming up roses. ;)

/johnny

36 posted on 09/21/2012 7:29:45 PM PDT by JRandomFreeper (Gone Galt)
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To: neverdem

So thanks to those bacteria being left alive, will we now have instead of “Typhoid Mary” a “MRSA Mary” wandering around and infecting hundreds or even thousands?

I sometimes wonder if these egghead types think these things through...

I admit it is an interesting approach, but there is a bigger picture here.


37 posted on 09/21/2012 7:31:09 PM PDT by djf (Political Science: Conservatives = govern-ment. Liberals = givin-me-it.)
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To: JRandomFreeper

I love FR...


38 posted on 09/21/2012 7:33:19 PM PDT by null and void (Day 1340 of our ObamaVacation from reality - Obama, a queer and present danger)
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To: whiterhino

“If they think they are making good progress now, wait till they try vinegar.”

Oregano Oil really works, too.


39 posted on 09/21/2012 7:38:36 PM PDT by PastorBooks
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To: Biggirl

There’s a dental “peroxide” you can get to use on gums/mouth if you feel something “coming on”. Sorry can’t remember the name but can be found at the drugstore and probably walmart. I used to have a lot of problems and found it worked miracles very quickly.


40 posted on 09/21/2012 7:39:26 PM PDT by visualops (artlife.us)
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To: B4Ranch
What is O2 level? I brush my teeth with baking soda instead of toothpaste and have for years.
41 posted on 09/21/2012 7:49:59 PM PDT by Ditter
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To: Right Wing Assault

“Why would you go to a doctor if all these alternative cures are so great?”

If something happened that I needed CPR or stitched up, then I’d go. Just about anything else will be treated at home. I’m guessing you haven’t seen what I have or spent years following alternative medicine and big pharma. Iatrogenic- theres a word.... FWIW, I graduated from the top nursing school in my state, one of the top in the country, and worked at a top teaching hospital. Follow the money.


42 posted on 09/21/2012 7:49:58 PM PDT by pops88 (Standing with Breitbart for truth.)
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To: null and void
Much larger percentage of well-read smartasses than the average population, that's for sure. Especially on a Friday night. ;)

/johnny

43 posted on 09/21/2012 8:07:15 PM PDT by JRandomFreeper (Gone Galt)
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To: Right Wing Assault

Here’s a case in point since you seem skeptical. My daughter developed a urinary tract infection that presented after office hours. I put her in a cool tub and gave her about 4 oz beer (pain relief and flushing.) That was followed by cranberry juice and dried cranberries. Saved me probably upwards of $100 in doctor’s bills. There are many, many remedies that have been lost thanks to the culture of big pharma. My nursing instructors were old, pre-WWII broads. They were some tough, no B.S. women. “But this practice contradicts what you just taught us...” followed by a stern look to get a clue.


44 posted on 09/21/2012 8:15:22 PM PDT by pops88 (Standing with Breitbart for truth.)
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To: Ditter

O2 = Oxygen

Brushing your teeth with Baking Soda is a very good idea because you cannot swallow any flouride or other chemicals. I found an old tube of Colgate Total in the guest bathroom.

the Inactive Ingredients are

hydrated silica
glycerin
sorbitol
flavor,
PVM/MA
copolymer
sodium lauryl sulfate
cellose gum
sodium hydroxide
proplyene glycol
carrageenan
sodium sacharin
mica
titanium dioxide
FD&C blue no.1
D&C yellow no.10

Exactly what is meant by the “inactive ingrediants” term I don’t know but since the area under your tongue is the most porous place on your body if you have your underwear on. Myself, I don’t want all these chemicals being absorbed into my system when I brush my teeth.

the Active Ingredients are

Sodium flouride
Triclosan

All of which you nor I consume twice a day.


45 posted on 09/21/2012 8:31:05 PM PDT by B4Ranch (There's Two Choices... Stand Up and Be Counted ... Or Line Up and Be Numbered .)
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To: B4Ranch
A few months ago I bought a tube of toothpaste, it contained baking soda and hydrogen peroxide. I brush with baking soda and sometimes gargle with peroxide, so I thought the toothpaste would be perfect for me. Within a few weeks my tongue was swollen and the inside of my mouth felt like it had been scalded. It came on slowly so it took me a week or so to figure it out. It was probably the “inactive ingredients” that you listed. Not so very inactive in my case. LOL!
46 posted on 09/21/2012 8:41:05 PM PDT by Ditter
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To: whiterhino

Oil of Oregano. Killer stuff.


47 posted on 09/21/2012 9:22:08 PM PDT by Secret Agent Man (I can neither confirm or deny that; even if I could, I couldn't - it's classified.)
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To: Secret Agent Man
Yes, as is GSE (Grapefruit Seed Extract) I have the liquid and the capsules - use it both topically and internally and it kicks just about any infection in a day or two. It also comes as a nasal spray.

We have a bottle of GSE "Ear Drops", which is GSE, glycerin and Tea Tree oil - the best remedy for anything on the skin. My girls thought I was nuts, but now any time they have a breakout and I say, "put some ear drops on it", they will answer with "already did".

Angstrom silver is also very good - inside and out - smaller particle size than colloidal - won't make you turn gray.

48 posted on 09/21/2012 9:41:48 PM PDT by Mygirlsmom (Our only Hope is Obama's Change.........of Address!!!!)
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To: RegulatorCountry

Silver is a very powerful antibiotic.

On my birth certificate, there is a spot for “Eye treatment” or somesuch, and it has AgHO3 in the box.

Silver Nitrate.

They use (or at least used to) an antibiotic treatment in the eyes to prevent infections that the infant might come in contact to from passage through the birth canal.

And Silver Sulfadiazene is still the treatment of choice for severe burns.
It promotes healing and prevents infections.


49 posted on 09/21/2012 10:03:49 PM PDT by djf (Political Science: Conservatives = govern-ment. Liberals = givin-me-it.)
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To: djf

Oooopps, typo, not AgHO3, AgNO3.

I need a brighter light on my keyboard...


50 posted on 09/21/2012 10:22:20 PM PDT by djf (Political Science: Conservatives = govern-ment. Liberals = givin-me-it.)
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