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Experts: New diabetes treatment flushes sugar, calories out of body
KVUE ^ | April 3, 2013 | Karen Grace

Posted on 04/05/2013 12:59:11 PM PDT by neverdem

A new diabetes drug that hit the market in the past week boasts it can drop your glucose levels and flush out "guilty" calories every time you use the bathroom.

Experts say that every time the patient urinates, out goes all the unwanted sugar and calories.

Doctors say this drug could even help prevent Type 2 diabetes.

KVUE's sister station KENS went behind closed doors at the Veterans Affairs hospital to witness clinical trials for other drugs similar to Invokana.

Last Friday, the FDA approved Invokana, a drug experts are hailing as a game changer for Type 2 diabetes treatment.

The drug works in the kidneys and blocks an enzyme that would put sugar back in the bloodstream.

Dr. Devjit Tripathy with UT Medicine San Antonio, the clinical practice of the School of Medicine at the UT Health Science Center, says the drug helps curb obesity.

"This drug not only has the potential to treat Type 2 diabetes but also obesity," Tripathy said. "With the loss of a lot of glucose, you lose a lot of calories and by that you lose weight."

He said the same weight loss results can occur in non-diabetic subjects, but he emphasized that so far the drug is only approved for Type 2 diabetes patients and not specifically as a weight-loss drug.

"In San Antonio, we have a very big problem with obesity," Tripathy said. "This drug will definitely help us."

He also said this drug has the potential to help prevent Type 2 diabetes.

Keep in mind taking this drug doesn't mean you can eat whatever you want. The doctor said the drug is limited on how much sugar is excreted, so it's important to continue watching your diet.

Experts say they are still assessing the long-term effects of the medication.


TOPICS: Culture/Society; Government; News/Current Events
KEYWORDS: canagliflozin; diabetes; invokana; obesity; type2diabetes
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Invokana, aka canagliflozin, "works in the kidneys and blocks an enzyme that would put sugar back in the bloodstream." Here's more from Forbes.
1 posted on 04/05/2013 12:59:12 PM PDT by neverdem
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To: neverdem

Yeah, that sounds safe and non invasive. What could go wrong?

Diet and exercise. Don’t become someone’s chemistry experiment.


2 posted on 04/05/2013 1:02:52 PM PDT by brownsfan (Behold, the power of government cheese.)
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To: neverdem

Wow! Great news for a lot of people. Ignore type 2 diabetes and it’ll get you every time, and I’m afraid a lot of people have it but still neglect to take care of themselves despite knowing they have it. This ought to help.


3 posted on 04/05/2013 1:03:52 PM PDT by LibWhacker
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To: neverdem

Confucious say: Block action of enzyme long time much bad mojo.

See: statins, cox2 inhibitors, others.


4 posted on 04/05/2013 1:04:38 PM PDT by Black Agnes
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To: LibWhacker

And you have people like one of my kin who will say, ‘Hurray, I can stop watching my diet, eat what I want, and just take this pill!’.


5 posted on 04/05/2013 1:07:04 PM PDT by Black Agnes
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To: self

ping


6 posted on 04/05/2013 1:08:44 PM PDT by PetroniusMaximus
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To: brownsfan

I am 5-10 weigh 145# and walk 6 miles a day on an inclined treadmill.

Still have “pre-Diabetes. Will be looking into this.


7 posted on 04/05/2013 1:08:48 PM PDT by traderrob6
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To: brownsfan
Diet and exercise. Don’t become someone’s chemistry experiment.

I am constantly confounded that people will simply not accept this simple solution.

The body is an amazing machine, but you have to perform maintenance. Sitting in an office 8 hours a day, driving home and then sitting in front of the TV or computer until bedtime in between stuffing your pie hole with 3 meals and countless snacks is a certain death sentence.

And yet, people seem not to grasp why they are obese and have a plethora of ailments and maladies. Stunning.

No one has to be a middle-aged Olympian, put ya gotta move!

8 posted on 04/05/2013 1:12:58 PM PDT by Obadiah (High speed, low drag.)
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To: brownsfan

I thought everything you eat is broken down in the body and turned into sugar ,fuel for your body ,so if it’s flushed before it’s used ,could be trouble


9 posted on 04/05/2013 1:13:26 PM PDT by molson209
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To: traderrob6

Do you have a meter? Get one. Test your after meal sugars every 30 min for 3hr post meal. Not every time and forever, mind you. Just to find out which meals are jacking your sugar.

If it makes your sugar go up, don’t eat that. Or only eat 1/2 as much next time. Test again. Once you have an idea, stop eating the culprits!

My a1c was 13+ when I was diagnosed. It runs in the low 5’s or high 4’s now with only metformin. If it makes my sugar go over 100 post prandial, I don’t eat that.

Hint: sugar, starch, large volumes of food (even low starch veggies!) will jack your sugars. So will stress. Stress will cause my liver to dump sugar like nobody’s business.

It’s not just fat people. My mom weighs all of 105# soaking sopping wet. Her post prandial when she was tested 5 years ago? 300+. The most she’d ever weighed in her life was 118. That was the day before she had my kid brother.


10 posted on 04/05/2013 1:15:19 PM PDT by Black Agnes
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To: neverdem

Interesting. I just scheduled an appt with my Endocrinologist to discuss.


11 posted on 04/05/2013 1:15:57 PM PDT by pgkdan ( "Those who hammer their guns into plows will plow for those who do not." ~Thomas Jefferson)
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To: Black Agnes

Yep. If a person is in denial, he probably won’t bother with the pill. If he’s suicidal, he won’t take it. That’s a lot of people, unfortunately. IMO, this pill seems most likely to benefit someone who is already doing all he can do, but whose blood sugar is still out of control.


12 posted on 04/05/2013 1:21:48 PM PDT by LibWhacker
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To: Black Agnes

I’ve been testing for some time. I have a high fasting sugar for whatever reason.

I eat very little carbs and virtually no processed carbs or sugar. Small meals and lots of protein. Have a pretty good post prandial response (around 85 2 hr PP).

Metformin did absolutely nothing for me. Had better results with Chromium.


13 posted on 04/05/2013 1:27:11 PM PDT by traderrob6
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To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
FReepmail me if you want on or off the diabetes ping list.

I tend to shy away from new drugs.

14 posted on 04/05/2013 1:28:07 PM PDT by neverdem ( Xin loi min oi)
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To: Obadiah

There’s always some nut/crank in every medical thread (Actually two so far in this one) who pushes simple lifestyle changes as a cure-all for a complex metabolic disorder. Sure didn’t work for #7, nor many others. Don’t be so simple minded. The body, genetics and circumstances are much more complicated than you’ll ever grasp with that approach.


15 posted on 04/05/2013 1:28:52 PM PDT by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: Obadiah

I’m a nurse for over 35 yrs now....I can tell you some of the sickest people are skinny....a lot of them smokers or drug abusers or alcoholics....a lot of them have absolutely no reserves to sustain illness, so when illness strikes, it really comes hard...


16 posted on 04/05/2013 1:29:04 PM PDT by cherry
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To: traderrob6

Have your adrenals checked, just because.

Do you get sufficient sleep? Lack of sleep will give me high sugar too.


17 posted on 04/05/2013 1:29:05 PM PDT by Black Agnes
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To: Black Agnes

Adrenals, no. Sleep like a baby 8-9 hrs/night.


18 posted on 04/05/2013 1:32:23 PM PDT by traderrob6
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To: theKid51; Apple Blossom

ping


19 posted on 04/05/2013 1:35:07 PM PDT by bmwcyle (People who do not study history are destine to believe really ignorant statements.)
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To: brownsfan

I was diagnosed with type II when in my mid 50s. I wasn’t excessively overweight and I was/am primarily pre-diabetic, only a little bit above the norm. For six years diet and exercise worked just fine and I also lost weight. Then, the A1C and daily readings started to climb again so my doctor put me on some meds that brought things back to normal. She told me that sometimes as you age the diet and exercise no longer work as well so I’m now tied to the meds. If this gets me off the other two meds I’m all for it. I understand how it works and I’ve been following the progress for a few years now. Chemistry experiment indeed. You’re more of a chemistry experiment each time you swill a homebrew or custom beer than you are taking this.


20 posted on 04/05/2013 1:36:32 PM PDT by RJS1950 (The democrats are the "enemies foreign and domestic" cited in the federal oath)
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To: brownsfan

it may be that age trumps diet and exercise....... that seems to be happening to me


21 posted on 04/05/2013 1:36:46 PM PDT by bert ((K.E. N.P. N.C. +12 .....History is a process, not an event)
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To: Black Agnes

22 posted on 04/05/2013 1:37:52 PM PDT by Jeff Chandler (People are idiots.)
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To: Jeff Chandler

Hey, how’d you get my picture?


23 posted on 04/05/2013 1:40:43 PM PDT by Black Agnes
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To: traderrob6
Were you one of the people with whom I discussed Gymnema sylvestre on another thread? To some degree it is a natural analogue to the drug discussed in this article and can knock a few points off fasting blood glucose. Not all that much help to a full-blown Type II diabetic, but for those in the pre- or borderline area, may be worth a trial. It is often combined with chromium which you already take.
24 posted on 04/05/2013 1:40:47 PM PDT by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: traderrob6

How many grams of sugar and starch do you eat? I’m assuming you’ve had your liver tested?

Dawn phenomenon is tricky. My mom had that for a while. She started eating one string cheese before bed and that fixed it.

YMMV, of course.


25 posted on 04/05/2013 1:42:21 PM PDT by Black Agnes
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To: steve86

Nope, the first I have heard of that. Will do some research on it though.

Thanks.


26 posted on 04/05/2013 1:44:20 PM PDT by traderrob6
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To: FReepers
Did You Hear It First On FR?


Click The Pic To Donate

Support FR, Donate Monthly If You Can

27 posted on 04/05/2013 1:46:00 PM PDT by DJ MacWoW (My faith and politics cannot be separated)
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To: neverdem

Wow! We can urinate calories now. Who knew? Idiot “journalists”.


28 posted on 04/05/2013 1:50:46 PM PDT by Bigg Red (Restore us, O God of hosts; let your face shine, that we may be saved! -Ps80)
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To: traderrob6
“Metformin did absolutely nothing for me. Had better results with Chromium.”

***

Metformin helped damage my kidneys and chromium did absolutely nothing for me.

There is no one size fits all diet or treatment that works for every diabetic. We just have to find what’s best for us individually.

29 posted on 04/05/2013 1:54:46 PM PDT by fatnotlazy
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To: Black Agnes

I eat peanuts/almonds for a late night snack and that helps a bit.

Carbs around 40/day

Sugars: 20 or less.

Liver enzymes were A-OK last time checked.


30 posted on 04/05/2013 1:55:18 PM PDT by traderrob6
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To: traderrob6

LOL.

Starve?

Your liver hates you.

That’s ok, mine hated me too for a while. Maybe they can form a support group or something.

The only thing i’ve done differently lately is take probiotics. And make sure I get enough vitamin d3. That helped my sugars too. I was paaaasty white when my a1c was 13. I get nice and tan in the summer. Helps my energy level too.


31 posted on 04/05/2013 1:57:23 PM PDT by Black Agnes
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To: Black Agnes
"Confucious say: Block action of enzyme long time much bad mojo. See: statins, cox2 inhibitors, others."


Indeed....increasing the glucose content in the bladder of a diabetic patient? what could go wrong?
32 posted on 04/05/2013 1:59:25 PM PDT by The_Sword_of_Groo (My world view is accurately expressed in the lyrics of " The Fightin' Side of Me")
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To: neverdem
” I tend to shy away from new drugs.”

***

Me too...until they have been in use for some time and appear to be safe and effective.

When Januvia came on the market, I had various medical professionals, friends and relatives push me into trying it. I didn't. My family doctor said it was too new. Sure enough, some serious issues have developed.

33 posted on 04/05/2013 1:59:46 PM PDT by fatnotlazy
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To: Black Agnes
Lack of sleep will give me high sugar too.

Too many sweet dreams.

34 posted on 04/05/2013 1:59:56 PM PDT by Graybeard58 (_.. ._. .. _. _._ __ ___ ._. . ___ ..._ ._ ._.. _ .. _. .)
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To: Graybeard58

Ok, I have to tell this. One night I dreamed I was in Krispy Kreme. Even the smell was right. I was eating a whole dozen flat of those. Chocolate covered with the icing in the middle. (no telling the carbs in those, I do NOT want to know!). When I woke up my sugar was 120. Which never happens. It’s always somewhere between 80 and 85 fasting. All I can think is my dream convinced my liver that a bunch of sugar was on the way. Or something.

Or maybe my sugar went up for some reason and my body felt that and adjusted my dreams accordingly.

I miss those donuts.


35 posted on 04/05/2013 2:03:42 PM PDT by Black Agnes
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To: Black Agnes

My A1C is not really bad (5.9)it’s just that dang “Dawn Phenom” you mentioned.

I guess inexplicable would be the word to describe it.


36 posted on 04/05/2013 2:05:43 PM PDT by traderrob6
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To: The_Sword_of_Groo

Antibiotic manufacturers are gearing up for the inevitable UTI’s right now!

Long cranberry futures!


37 posted on 04/05/2013 2:07:11 PM PDT by Black Agnes
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To: Black Agnes
My husband often wakes up with higher sugar than when he went to bed. He always blames his liver. Maybe it is dreams+liver.
38 posted on 04/05/2013 2:07:35 PM PDT by Ditter
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To: Ditter

If I wake up after an action dream where I’m running or afraid or something my sugar is always higher. It’s like my liver is dumping it because i’m going to need it


39 posted on 04/05/2013 2:09:23 PM PDT by Black Agnes
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To: traderrob6

That’s probably what’s driving up your a1c.

Now, I’m off to slave to my recumbant bike. Getting old sucks.


40 posted on 04/05/2013 2:12:52 PM PDT by Black Agnes
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To: neverdem
Last Friday, the FDA approved Invokana, a drug experts are hailing as a game changer for Type 2 diabetes treatment.

How soon before the ambulance chasers start the commercials about how you can get billions by suing the drug manufacturer?

Funny how the FDA never gets sued.

41 posted on 04/05/2013 2:14:14 PM PDT by hattend (Firearms and ammunition...the only growing industries under the Obama regime.)
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To: Black Agnes

My husband has wild and crazy dreams almost every night, you may be on to something.


42 posted on 04/05/2013 2:14:21 PM PDT by Ditter
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To: Black Agnes

Hope it’s in front of the TV. Only way I can survive the 6 miles on the treadmill I endure every day.


43 posted on 04/05/2013 2:15:35 PM PDT by traderrob6
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To: traderrob6

Recumbant bike has handle bar thingies that I can prop a book on. I usually read. I’m trying to get back to riding for 30 or 45m a day. Soon it will be garden season and I’ll get plenty of exercise then.


44 posted on 04/05/2013 2:18:05 PM PDT by Black Agnes
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To: Black Agnes
All I can think is my dream convinced my liver that a bunch of sugar was on the way. Or something.

The brain is a powerful thing.

Unless it's encased in the skull of a liberal.

45 posted on 04/05/2013 2:22:25 PM PDT by Graybeard58 (_.. ._. .. _. _._ __ ___ ._. . ___ ..._ ._ ._.. _ .. _. .)
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To: steve86
There’s always some nut/crank in every medical thread (Actually two so far in this one) who pushes simple lifestyle changes as a cure-all for a complex metabolic disorder. Sure didn’t work for #7, nor many others. Don’t be so simple minded. The body, genetics and circumstances are much more complicated than you’ll ever grasp with that approach.

Your comment is so true it needed to be repeated.

The human body's complexity is so great that it can never be comprehended. It is also a highly adaptive system, operating in a complex and ever-changing environment. To reduce things to simple (-minded) declarative statements is silly.

Ultimately, all you can do is apply common sense, listen to your bodies' feedback, and treat yourself as a unique experiment (the "n=1" philosophy).

Having said that, bone broth cures everything, so you could just go with that, instead.
46 posted on 04/05/2013 2:30:09 PM PDT by jjsheridan5
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To: brownsfan
I am walking around after being in the hospital for four days? Why? Because I bit a cuticle. It got infected. Three procedures later I am home for another week.

I've lost ten pounds and I am not stopping until I am drug free.

Every time I go to the kitchen, I look at this huge bandage, and think of my mangled finger. What a damned waste. I should have dumbass tattooed on my forehead.

In my case this incident was completely avoidable.

Get your sugar under control. Get off the meds.

Or the best thing they will do is slice your finger open like a hot dog.

47 posted on 04/05/2013 2:31:09 PM PDT by Vermont Lt (Does anybody really know what time it is? Does anybody really care?)
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To: neverdem

As many Type 2 diabetics have figured out, high blood sugar at night means more trips to the restroom to expel sugar. It sounds to me like this treatment could cause some people to lose sleep. Urine isn’t the only fluid that expels excess sugar. The body can send it out through the sinuses also. Clogged sinuses, dry mouth, sleep apnea, and waking to drink fluids are not pleasant experiences. I bring all this up because many doctors don’t have a clue that these maladies are related to high blood sugar. They may not use any discretion when recommending when patients should take this drug. Just my 2 cents on the subject. Feel free to disregard it.


48 posted on 04/05/2013 2:47:01 PM PDT by pallis
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To: neverdem

I wonder how much they will charge for this new drug.

Probably megabucks!


49 posted on 04/05/2013 3:17:04 PM PDT by Petruchio (Democrats are like Slinkies... Not good for anything, but it's fun pushing 'em down the stairs.)
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To: Black Agnes; DMZFrank; Trueblackman; mhking; Black Republican for Bush; BlackElk; blackie
And make sure I get enough vitamin d3.

I'll assume you are black. Blacks taking vitamin D supplements could have an increased risk of calcified arteries.

Vitamin D, Adiposity, and Calcified Atherosclerotic Plaque in African-Americans

Widespread Vit D Supplementation Questioned

50 posted on 04/05/2013 3:33:17 PM PDT by neverdem ( Xin loi min oi)
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