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Mammoth Blood Brought Back to Life with Ancient DNA
Scientific Computing ^ | 5/10/10

Posted on 05/10/2010 10:10:56 AM PDT by null and void

The structural model of the mammoth hemoglobin, with the three key changes to the protein highlighted in red. Illustration by Ansgar Philippsen

A team of international researchers has brought the primary component of mammoth blood back to life using ancient DNA preserved in bones from Siberian specimens 25,000 to 43,000 years old. Studies of recreated mammoth hemoglobin, published May 3, 2010, in Nature Genetics, reveal special evolutionary adaptations that allowed the mammoth to cool its extremities down in harsh Arctic conditions to minimize heat loss.

"It has been remarkable to bring a complex protein from an extinct species, such as the mammoth, back to life," says Alan Cooper, Director of the Australian Centre for Ancient DNA (ACAD) at the University of Adelaide, where the mammoth hemoglobin sequences were determined. "This is true paleobiology, as we can study and measure how these animals functioned as if they were alive today."

Cooper is an Australian Research Council Future Fellow and a member of the University's Environment Institute.

"We've managed to uncover physiological attributes of an animal that hasn't existed for thousands of years," says team leader Kevin Campbell of the University of Manitoba, Canada. "Our approach opens the way to studying the biomolecular and physiological characteristics of extinct species, even for features that leave no trace in the fossil record."

The project began over seven years ago when Campbell contacted Cooper, who was then based at the University of Oxford, to suggest resurrecting mammoth hemoglobin.

"At the time, I thought 'what a great idea' — but it's never going to work," says Cooper. "Still, bringing an extinct protein back to life is such an important concept, we've got to try it."

The team converted the mammoth hemoglobin DNA sequences into RNA, and inserted them into modern-day E. coli bacteria, which then manufactured the authentic mammoth protein.

"The resulting hemoglobin molecules are no different than 'going back in time' and taking a blood sample from a real mammoth," says Professor Campbell.

The team used modern scientific physiological tests and chemical modeling to characterize the biochemical properties that confer mammoths with physiological cold tolerance. Team member Roy Weber of the University of Aarhus, Denmark, who performed the physiological testing on the mammoth proteins, says the findings help show how the mammoth survived the extreme Arctic cold.

"Three highly unusual changes in the protein sequence allowed the mammoth's blood to deliver oxygen to cells even at very low temperatures, something that indicates adaptation to the Arctic environment," Weber says.

"We can now apply similar approaches to other extinct species, such as Australian marsupials," says team member Jeremy Austin, ACAD Deputy Director, who is currently using ancient DNA to study the evolution of the extinct thylacine and the endangered Tasmanian Devil.


TOPICS: Miscellaneous
KEYWORDS: dna; godsgravesglyphs; mammoths; mtdna
Thereby proving creation to the creationists and evolution to the evolutionists....
1 posted on 05/10/2010 10:10:56 AM PDT by null and void
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To: null and void
The future is now...

2 posted on 05/10/2010 10:14:10 AM PDT by TSgt (We will always be prepared, so we may always be free. - Ronald Reagan)
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To: null and void

One day we might even see these creatures walk the Earth again. Of course proving creationism and evolution at the same time.


3 posted on 05/10/2010 10:15:04 AM PDT by CodeToad
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To: SunkenCiv
I think this duplicates one of your posts.
4 posted on 05/10/2010 10:15:32 AM PDT by colorado tanker
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To: null and void
I don't know about creationism — but, it certainly demonstrates a kind of intelligent design at work.

BTW — something everyone seems to forget — Darwin's Theory of Evolution says nothing whatsoever about the beginnings of life (just speciation).

5 posted on 05/10/2010 10:15:51 AM PDT by USFRIENDINVICTORIA
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To: CodeToad

I already saw that movie.


6 posted on 05/10/2010 10:17:45 AM PDT by swain_forkbeard (Rationality may not be sufficient, but it is necessary.)
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To: null and void

“inserted them into modern-day E. coli bacteria”

That’s kind of a cr@ppy method to use!


7 posted on 05/10/2010 10:20:42 AM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: swain_forkbeard

Ah, yes. “Jurassic Pork.”


8 posted on 05/10/2010 10:20:47 AM PDT by fieldmarshaldj (~"This is what happens when you find a stranger in the Amber Lamps !"~~)
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To: null and void

Oh thank goodness ... Now the Flintstones can get that new Dishwasher.


9 posted on 05/10/2010 10:21:43 AM PDT by TexGuy (If it has the slimmest of chances of being considered sarcasm ... IT IS!)
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To: null and void
I look forward to developing recipes for the soon-to-be no-longer-extinct mammoth. Bet it doesn't taste like chicken.

/johnny

10 posted on 05/10/2010 10:21:59 AM PDT by JRandomFreeper (Gone Galt)
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To: null and void; SunkenCiv

If they can produce mammoth blood or hemoglobin they can give transfusions to cloned mammoths that are shot by mid-western farmers trying to save their crops.

Mammoths, cave bears and triceatrops, oh my! What a wonderful world it will be.


11 posted on 05/10/2010 10:23:33 AM PDT by wildbill (You're just jealous because the Voices talk only to me.)
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To: null and void

Great, if my mammoth needs a transfusion I know where to take it!


12 posted on 05/10/2010 10:23:57 AM PDT by SWAMPSNIPER (The Second Amendment, A Matter Of Fact, Not A Matter Of Opinion)
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To: null and void

Wouldn’t this make it possible to pursue cloning?

It’s strange to read this article with cloning not being mentioned at all. Perhaps the reason is the answer to my question, but what is described here seems to indicated the possibility.


13 posted on 05/10/2010 10:25:24 AM PDT by DoughtyOne (Excusaholic: MeCain lost to Jr., RINO endorsements are flying, & you live at 2012 Denial Blvd.)
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To: DoughtyOne

One obvious thing I neglected to mention, is the timing of this. We’ve got Obama and the communist movement in the United States trying to take us back about one century. What better time to go back even farther?

It would be entirely fitting to have mammoths walking around, as we install a tried and failed economic system in the United States.

Prehistoric indeed...


14 posted on 05/10/2010 10:28:38 AM PDT by DoughtyOne (Excusaholic: MeCain lost to Jr., RINO endorsements are flying, & you live at 2012 Denial Blvd.)
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To: DoughtyOne

Yes.


15 posted on 05/10/2010 10:33:40 AM PDT by patton (Obama has replaced "Res Publica" with "Quod licet Jovi non licet bovi.")
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To: null and void
This is prove positive we didn't evolve!


16 posted on 05/10/2010 10:36:10 AM PDT by BushCountry (scratch here ############################### to reveal my thoughts on the Obama Administration.)
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To: null and void

God made a decision that these creatures were not compatible with the human race sharing the same planet. God created the scenario whereby they were destroyed; He had His reasons.

If scientist continue to mess with God’s design, God will make another decision to reveal who is boss. Creating extinction scenarios is easy for God and if Man doesn’t knock it off, those scenarios will play out soon.


17 posted on 05/10/2010 10:38:16 AM PDT by Integrityrocks
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To: patton

Thanks. And that being the case, this is very interesting news.


18 posted on 05/10/2010 10:40:15 AM PDT by DoughtyOne (Excusaholic: MeCain lost to Jr., RINO endorsements are flying, & you live at 2012 Denial Blvd.)
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To: Integrityrocks

If He had planned ahead He wouldn’t have created them in the first place would He?


19 posted on 05/10/2010 10:43:14 AM PDT by null and void (We are now in day 473 of our national holiday from reality. - 0bama really isn't one of US.)
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To: USFRIENDINVICTORIA

BTW — something everyone seems to forget — Darwin’s Theory of Evolution says nothing whatsoever about the beginnings of life (just speciation).

How convenient.

The origin of living species is a valid subject for science to investigate, but not the origin of what species are species of? That’s like studying inductance and capacitance without studying electricity.

Another absurd assertion of evolutionists.

Hank


20 posted on 05/10/2010 10:43:53 AM PDT by Hank Kerchief
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To: TSgt

Now I can understand how she opens her mouth that wide


21 posted on 05/10/2010 10:44:05 AM PDT by hecht (NEXT YEAR IN JERUSALEM)
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To: Integrityrocks
f scientist continue to mess with God’s design, God will make another decision to reveal who is boss.

Why would He do that? Either God gave man free-will or God is a dictator. Can't have it both ways.

If God is a dictator who wants man to obey His will, then why does He allow man to kill other men?

22 posted on 05/10/2010 10:44:18 AM PDT by Ol' Dan Tucker (People should not be afraid of the government. Governement should be afraid of the people)
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To: null and void
Thereby proving creation to the creationists and evolution to the evolutionists....

...hematology to the hematologists...

23 posted on 05/10/2010 10:45:56 AM PDT by decimon
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To: DoughtyOne

Interesting indeed.

Do you think that the Russian peasents that found the occasional frozen wooly mammoth ever made a fur coat out of one?

What would that be worth?


24 posted on 05/10/2010 10:49:56 AM PDT by patton (Obama has replaced "Res Publica" with "Quod licet Jovi non licet bovi.")
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To: decimon

Bingo!


25 posted on 05/10/2010 10:51:42 AM PDT by null and void (We are now in day 473 of our national holiday from reality. - 0bama really isn't one of US.)
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To: BushCountry
So that's what happened to Snuffleapugus Sniffleap Shuffleupedgus Big Bird's friend...
26 posted on 05/10/2010 10:56:08 AM PDT by IYAS9YAS (Liberal Logic: Mandatory health insurance is constitutional - enforcing immigration law is not.)
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It’s bad enough the fools have repopulated the black bear and wolf. Having to watch out for cave bears and saber tooths, or sitting down a tv show with one eye opened for a mad mammoth is just insane. “Honey, hand me the magnum, I’m going to check the Giant Moa coup...”


27 posted on 05/10/2010 11:21:00 AM PDT by LRS (Just contracts; just laws; just a constitution...)
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To: null and void

After reading on the dna extraction processes my first question is how can they be so confident that pristine dna as it exists in the cell is the result they are working with.


28 posted on 05/10/2010 12:07:20 PM PDT by valkyry1
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To: CodeToad
One day we might even see these creatures walk the Earth again. Of course proving creationism and evolution at the same time.

How cool would that be - and not because of the endless ID/evolution bickering. A living, breathing mammoth would be right up there with the moon landing in terms of humanity's most spectacular technological achievements.
29 posted on 05/10/2010 12:08:17 PM PDT by AnotherUnixGeek
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To: Integrityrocks

I totally agree with that.


30 posted on 05/10/2010 12:09:27 PM PDT by valkyry1
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To: null and void

Let’s clone millions of them, make them meaner than he@# and put them all along the southern border ... Sure, T-Rex’s would be better but that will come with time.


31 posted on 05/10/2010 12:09:54 PM PDT by Scythian
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To: Dr. Bogus Pachysandra

E. coli is used in almost all GMO pharming techniques, it’s used to carry it’s payload (usually genes) into the cell nucleus itself.


32 posted on 05/10/2010 12:11:11 PM PDT by Scythian
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To: AnotherUnixGeek

Totally agree! Imagine just having DNA being enough to bring back extinct life. wow.


33 posted on 05/10/2010 12:25:08 PM PDT by CodeToad
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To: Scythian

I know that Scyth! I was making a, rather poor I guess, joke! I run a water company/public utility, and am quite aware of E. Coli. Test for it every month.


34 posted on 05/10/2010 12:26:23 PM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: colorado tanker; wildbill; null and void

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35 posted on 05/10/2010 3:18:58 PM PDT by SunkenCiv ("Fools learn from experience. I prefer to learn from the experience of others." -- Otto von Bismarck)
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36 posted on 05/10/2010 3:34:03 PM PDT by SunkenCiv ("Fools learn from experience. I prefer to learn from the experience of others." -- Otto von Bismarck)
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To: Scythian

That is entirely scary.


37 posted on 05/10/2010 5:53:01 PM PDT by patton (Obama has replaced "Res Publica" with "Quod licet Jovi non licet bovi.")
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To: patton

To PETA or the normal world? ;-)

I guess there might be a lot of DNA in that hair, but would that still be viable? The skin shouldn’t be should it?


38 posted on 05/11/2010 7:27:58 AM PDT by DoughtyOne (Excusaholic: MeCain lost to Jr., RINO endorsements are flying, & you live at 2012 Denial Blvd.)
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To: DoughtyOne

I honestly don’t know. But it is mammoth food for thought.


39 posted on 05/13/2010 4:52:44 AM PDT by patton (Obama has replaced "Res Publica" with "Quod licet Jovi non licet bovi.")
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To: patton

;-)


40 posted on 05/13/2010 7:51:17 AM PDT by DoughtyOne (Excusaholic: MeCain lost to Jr., RINO endorsements are flying, & you live at 2012 Denial Blvd.)
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To: swain_forkbeard
I already saw that movie.

But a great movie is always worth seeing again and again!

41 posted on 05/13/2010 8:00:42 AM PDT by Willie Green
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