Free Republic

Gamers, bitcoin "miners" and companies large and small have teamed up for an unprecedented data-crunching effort that aims to harness idle computing power to accelerate research for a coronavirus treatment. The project led by computational biologists has effectively created the world's most powerful supercomputer that can handle trillions of calculations needed to understand the structure of the virus. More than 400,000 users downloaded the application in the past two weeks from "Folding@Home," according to director Greg Bowman, a professor of biochemistry and molecular biophysics at Washington University in St. Louis, where the project is based.

Congratulations to all Folding@Home team members for reaching the 1 Billion point Milestone.

It has been a while since our last Free Republic Folding@Home update. The team has seen growth in the past couple of years as contributors have added high performance GPUs from NVidia and AMD/ATI, and same consoles such as the PS3. The team started in 2001 with a few volunteers, and grew dramatically in 2005 as we started actually posting regular threads. As we grew from a Top 2000 team to a Top 100 team, we attracted the attention of DU. After a couple of years of name calling, they realized that merely boasting that you can beat the opposition...

An unusual enzyme called telomerase acts on parts of chromosomes known as telomeres. The enzyme has recently been found in many human tumors and is being eyed as a new target for cancer therapyEditor's note: We are posting the main text of this article from the February 1996 issue of Scientific American for all our readers because the authors have won the 2009 Nobel Prize in Physiology or Medicine. Subscribers to the digital archive may obtain a full PDF version, complete with artwork and captions. Often in nature things are not what they seem. A rock on the seafloor may...

The U.S. Department of Veterans Affairs' cancellation of a $75 million contract with UT Southwestern Medical Center could mean the end to the Dallas university's research into treatments and cures for Gulf War illnesses. UT Southwestern epidemiologist Dr. Robert Haley told The Dallas Morning News that he and a team of 200 colleagues from eight universities are five years ahead of anyone else engaged in the painstaking research into why 200,000 healthy soldiers went to the Persian Gulf in 1990-91 and returned to civilian lives of chronic illness. ... A closer look at the body of research conducted by Haley...

SUMMARY. The influenza virus infects people and animals by binding to complex sugar molecules on the surface of the respiratory tract. Bird viruses bind most strongly to bird cell-surface sugars and human viruses bind most strongly to human cell-surface sugars. As the recent swine-origin influenza virus has demonstrated, there is considerable overlap between the binding ability of human and pig viruses to cells of the other host. Changes to this binding affinity are one key component for viruses to make a jump between species, and it is difficult to predict the necessary mutations ahead of time. We would like to...

Rocky Marciano, Muhammad Ali, Joe Frazier and Mike Tyson; Colossus, Cray, ASCI Red and Blue Gene. The names of boxing's heavyweights are never forgotten - and it's the same with the champs of the supercomputing world. These machines truly are like no others. Each is computationally more muscular than its predecessor; and for a while, each has claimed the title of the fastest computer in the world. But, as the calamitous fall of 'Iron' Mike Tyson showed us, champions are built to be felled. And so we've seem supercomputers come and go, growing from single processor machines capable of a...

Another site I am on is trying to start a small folding team. One "green" activist is trying to make the case that you would be better off sending money directly to cancer researchers rather than wasting energy by folding. His argument is that projects like folding and SETI have been wasting time and energy for years with nothing to show for it and all you are doing is putting money in the pockets of electric company executives. Are there any studies that show how much it costs to run folding 24/7 as opposed to just letting your pc sit...

Improving blood flow to brain is a preventive strategy CHICAGO --- A slow, chronic starvation of the brain as we age appears to be one of the major triggers of a biochemical process that causes some forms of Alzheimer's disease. A new study from Northwestern University's Feinberg School of Medicine has found when the brain doesn't get enough sugar glucose -- as might occur when cardiovascular disease restricts blood flow in arteries to the brain -- a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer's. Robert Vassar, lead author,...

... We present a novel computational approach for describing the formation of oligomeric assemblies at experimental concentrations and timescales. We propose an extension to the Markovian state model approach, where one includes low concentration oligomeric states analytically. This allows simulation on long timescales (seconds timescale) and at arbitrarily low concentrations (e.g., the micromolar concentrations found in experiments), while still using an all-atom model for protein and solvent. As a proof of concept, we apply this methodology to the oligomerization of an Abeta peptide fragment (Abeta 21–43). Abeta oligomers are now widely recognized as the primary neurotoxic structures leading to Alzheimer's...

With the 6.20 (classic & GPU) and 6.22 (SMP) clients out, we (Dr. Pande and the F@H team) can start looking forward to the next steps in client development. We still have some last bits of work to completely unify the clients, but the hard part is already completed there for the most part. The 6.2x series introduces several new features for donors, but in time, the clients have been getting gradually more and more complex to use. The Win/SMP and multi-gpu setups are examples of very challenging setups. Our primary plans for the future are to make setup much...

Mainly to help FReerepublic folders, but anyone can take advantage of this deal. Item number 7387-A11 (Refurbished) Lenovo 3000 J115 - Athlon 64 X2 Dual Core 2 GHz - RAM 1 GB - HD 250 GB - DVD±RW (+R DL) - Memory card reader - LAN- Fast Gig - Modem - Vista Home Premium. 1 year manuf. warr. incl. Subtotal: 210.00 Sales Tax: 0.00 Shipping: 30.32 Order Total: 240.32 Actually they are $230.00, but if you call the guy below, and ask him for a "folding@home" discount, he'll give you an additional $20.00 off. Tech For Less Cory -719-886-8000 ext....

OK, so I'll never be one of the top 10 and I'd have to almost double what I have now to even make the top 150 but persistence DOES pay off: Rank User Score WU 200 Oshkalaboomboom 23839 163

*** New PS3 client *** Sony has released an upgraded client for the PS3. Check out Noam Rimon's (he's the lead developer at Sony) post: Hello, Starting today a new version of Folding is available. This version is a minor fix to the previous 1.3 version and adds a better tuned algorithm that handles peak performance hours of Folding@home network, by acting differently to certain network errors if those occur. It is recommended that you update to the new version by quitting the application and restarting it. Your current WU will not be damaged in any way, in-fact Folding will...

We're often interested in comparing things--predicting a known difference is a good way to test our methods. Then, once we're pretty confident that things work, we want to predict ways to change the way proteins interact. Changing a system in a defined way is both a good tool for biological insight and the basis for a lot of medical treatments. In this particular case, we're interested in the "selectivity" of ligand binding by a protein: the protein is known to bind one small molecule ("ligand") much better than another. So project 3903/3905 is a pair of projects comparing the protein-small...

As we approach one million PLAYSTATION 3 consoles participating in the Folding@Home program, we continue to improve the FAH client. With the new Firmware v2.1 we also prepared an updated version of FAH, which can soon be automatically downloaded by clicking on the FAH icon. This updated version includes the following new features: If you happen to be one of the people that wants to leave their machine running after they finished their late-night gaming session, but wish to shut it down after a limited period of time, we have a great tip for you: Go to Settings menu, select...

A plea to all owners of new computers and PS3s this weekend to strongly consider adding the Folding@home program to your new system to run in the background. Why? Because Alzheimer's Disease, Mad Cow (BSE), CJD, ALS, Huntington's Disease, Parkinson's Disease, and many Cancers and cancer-related syndromes are partially or wholly caused by mid-folded proteins. You can help by simply running a piece of software. Folding@home is a distributed computing project -- people from throughout the world download and run software to band together to make one of the largest supercomputers in the world. Every computer takes the project closer...

Scientists have moved a step closer to finding a cure for Alzheimer's, it has been revealed. Biologists have developed a compound which has successfully prevented the disease killing brain cells, improving memory and learning ability that was already damaged. The researchers at the University of St Andrews, working with scientists in the US, have developed man-made compounds capable of blocking a nerve cell interaction known to lead to the symptoms of the disease. The results of the study - carried out in the laboratory using a model of the disease - have prompted the Alzheimer's Research Trust to help fund...

Researchers at UT Southwestern Medical Center in Dallas TX are seeking patients to participate in medical studies for Parkinson’s disease, Alzheimer’s disease and low-back pain. All clinical trials are approved by UT Southwestern’s Institutional Review Board, which reviews them for benefits, risks, side effects and informed consent. Parkinson’s UT Southwestern Medical Center researchers are enrolling patients with Parkinson’s disease to determine if creatine, normally used as a nutritional supplement, can slow the progression of the disease. Study participants will receive either creatine or a placebo and must not take creatine outside the study during the trial. The investigators will measure...

The Brain Tour explains how the brain works and how Alzheimer's affects it. Start Brain Tour Taking the tour: There are 16 interactive slides. As you view each slide, roll your mouse over any colored text to highlight special features of each image. Then, click on the arrow to move to the next slide.