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Influenza vaccine effectiveness in the community and the household (lower effectiveness with repeated vaccination and no protection given household exposure)
PubMed ^ | February 14, 2013 | Suzanne E Ohmit, Joshua G Petrie, Ryan E Malosh, Benjamin J Cowling, Mark G Thompson, David K Sha

Posted on 01/02/2022 7:24:00 PM PST by DoodleBob

Abstract

Background: There is a recognized need to determine influenza vaccine effectiveness on an annual basis and a long history of studying respiratory illnesses in households.

Methods: We recruited 328 households with 1441 members, including 839 children, and followed them during the 2010-2011 influenza season. Specimens were collected from subjects with reported acute respiratory illnesses and tested by real-time reverse transcriptase polymerase chain reaction. Receipt of influenza vaccine was defined based on documented evidence of vaccination in medical records or an immunization registry. The effectiveness of 2010-2011 influenza vaccination in preventing laboratory-confirmed influenza was estimated using Cox proportional hazards models adjusted for age and presence of high-risk condition, and stratified by prior season (2009-2010) vaccination status.

Results: Influenza was identified in 78 (24%) households and 125 (9%) individuals; the infection risk was 8.5% in the vaccinated and 8.9% in the unvaccinated (P = .83). Adjusted vaccine effectiveness in preventing community-acquired influenza was 31% (95% confidence interval [CI], -7% to 55%). In vaccinated subjects with no evidence of prior season vaccination, significant protection (62% [95% CI, 17%-82%]) against community-acquired influenza was demonstrated. Substantially lower effectiveness was noted among subjects who were vaccinated in both the current and prior season. There was no evidence that vaccination prevented household transmission once influenza was introduced; adults were at particular risk despite vaccination.

Conclusions: Vaccine effectiveness estimates were lower than those demonstrated in other observational studies carried out during the same season. The unexpected findings of lower effectiveness with repeated vaccination and no protection given household exposure require further study.

(Excerpt) Read more at pubmed.ncbi.nlm.nih.gov ...


TOPICS: Health/Medicine; History; Reference
KEYWORDS: fluvaccine; influenza; vaccines; ve
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Incredibly, subjects who got flu shots in the 2010-2011 flu season and prior/2009-2010 season had a negative VE, e.g. Higher rate of infection.

As stated in an accompanying editorial,

Remarkably, the rate of... influenza illness was not substantially different between those subjects who received influenza vaccine and those who did not.... The second surprising finding is that receipt of influenza vaccination in a previous season may have impacted the effectiveness of the vaccine in the current season. The population under study was predominantly young healthy adults and children with a low frequency of chronic health conditions, the types of subjects that typically mount the best immune responses to vaccine... the apparent failure of influenza vaccine under optimal conditions seen in this study is indeed troubling.

Perhaps this offers some insight into the longer-term help (or not) of successive COVID19 boosters.

1 posted on 01/02/2022 7:24:00 PM PST by DoodleBob
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To: ransomnote; metmom; Jane Long; DoughtyOne; SeekAndFind

For your consideration.


2 posted on 01/02/2022 7:25:24 PM PST by DoodleBob (Gravity's waiting period is about 9.8 m/s^2)
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To: DoodleBob
More on Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign A deeper look at a decisive limitation of our adaptive immune systems.
3 posted on 01/02/2022 7:26:00 PM PST by mewzilla (Those aren't masks. They're muzzles. )
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To: DoodleBob

I’m starting to think that the “experts” don’t know jack #### and are just in it for the government grants.


4 posted on 01/02/2022 7:27:26 PM PST by imabadboy99
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To: DoodleBob

It’s a virus with a 99 percent-plus survival rate.

Like a whole lot of other viruses.

There has never been any reason for ANY of this drama and hysteria.

Except $$$ for those in the inner circles, who are playing the world’s hypochondriacs and Karens for everything they’re worth.


5 posted on 01/02/2022 7:36:13 PM PST by JennysCool ("It's easier to fool people than to convince them that they have been fooled." - Mark Twain)
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To: JennysCool

The original goal was getting rid of The Orange Man.


6 posted on 01/02/2022 7:37:35 PM PST by dfwgator (Endut! Hoch Hech!)
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To: JennysCool

There has never been any reason for ANY of this drama and hysteria.


REmember how you bought an extra case of beans from the millennia hysteria that computers would stop working?

I do..........................


7 posted on 01/02/2022 7:38:17 PM PST by PeterPrinciple (Thinking Caps are no longer being issued but there must be a warehouse full of them somewhere.)
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To: JennysCool

BTTT.


8 posted on 01/02/2022 7:41:41 PM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12 )
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To: dfwgator

EXACTLY.

Right after Nancy got done tearing up the State of the Union, she called her pals in the NIH and CDC, and the other apparatchiks she’s owned lock stock and barrel for decades and barked, “How do we get rid of this horrible man? Any ideas?”

Once she also gave her bought-and-paid-for media their mission, the die was cast.


9 posted on 01/02/2022 7:44:12 PM PST by JennysCool ("It's easier to fool people than to convince them that they have been fooled." - Mark Twain)
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To: PeterPrinciple

Ha ha! Yep! We’re 22 years past the predicted horror of “Y2K.”

Happy New Year!


10 posted on 01/02/2022 7:45:48 PM PST by JennysCool ("It's easier to fool people than to convince them that they have been fooled." - Mark Twain)
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To: DoodleBob

So, like recreational injectibles? The more you use the more it takes to achieve the desired results? And some places are pushing for shot #4. WAKE UP DAMNIT!.

😨😷🐂💨💩💸


11 posted on 01/02/2022 7:56:35 PM PST by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: mewzilla

Thank you. That was very interesting.


12 posted on 01/02/2022 7:57:46 PM PST by DoodleBob (Gravity's waiting period is about 9.8 m/s^2)
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To: DoodleBob

Very interesting study.


13 posted on 01/02/2022 8:08:49 PM PST by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith…)
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To: JennysCool
Ha ha! Yep! We’re 22 years past the predicted horror of “Y2K.”


14 posted on 01/02/2022 8:10:51 PM PST by PROCON (Sic Semper Tyrannis)
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To: rktman; mewzilla; imabadboy99; kiryandil; Grampa Dave
The more you use the more it takes to achieve the desired results?

Oh, it gets BETTER.

A follow up sort of study covering FIVE years showed declining protection against influenza with increased yearly immunization.

AND, the VE is below 50%, which was the FDA's minimum threshold for COVID19 vaccine consideration.

Now, influenza isn't this bug. BUT, as stated in mewzilla's linked article...

Despite multiple reinfections across the whole population, we are never quite immune to the flu, because its strategy is to exploit the way our immune systems learn.

We are seeing this in real-time now.

I probably wouldn't be so peeved if the same dopes who yell at me that I must "trust the science" are now ignoring actual scientific research like this, and are pushing boosters based on a hope and some theoretical modeling.

But, as Grampa Dave taught us, this isn't about health...

15 posted on 01/02/2022 8:14:22 PM PST by DoodleBob (Gravity's waiting period is about 9.8 m/s^2)
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To: mewzilla

Yes, interesting.


16 posted on 01/02/2022 8:17:14 PM PST by Inyo-Mono
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To: PROCON
I was not compliant regarding all of that Y2K crap, and I am not compliant with this Covid vaccine zaniness. It is all lies.

They lie to us all of the time, for many years.

17 posted on 01/02/2022 8:19:09 PM PST by Radix (Politicians; the Law and the Profits. )
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To: DoodleBob

Interesting. Thanks for posting.


18 posted on 01/02/2022 8:21:28 PM PST by CheshireTheCat ("Forgetting pain is convenient.Remembering it agonizing.But recovering truth is worth the suffering")
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To: DoodleBob

Yeah, we don’t get those either. Or pneumonia shots.


19 posted on 01/02/2022 8:35:12 PM PST by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: DoodleBob

Just remember - the same people lecturing us to “trust the science” are the same ones that tell us there’s more than 2 genders.


20 posted on 01/02/2022 8:39:37 PM PST by imabadboy99
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