Posted on 01/06/2023 1:16:05 PM PST by Red Badger
Researchers at Brigham and Women’s Hospital have found a way to use cancer cells to fight cancer. In a study published in Science Translational Medicine, the team led by Khalid Shah demonstrated that their cell therapy could eliminate established tumors and create long-term immunity in an advanced mouse model of glioblastoma, a type of brain cancer. The vaccine works by training the immune system to prevent cancer from returning. These results are encouraging and suggest that this approach may be effective in treating cancer in humans.
Dual-action cell therapy engineered to eliminate established tumors and train the immune system to eradicate primary tumor and prevent cancer’s recurrence.
Scientists are harnessing a new way to turn cancer cells into potent, anti-cancer agents. In the latest work from the lab of Khalid Shah, MS, PhD, at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, investigators have developed a new cell therapy approach to eliminate established tumors and induce long-term immunity, training the immune system so that it can prevent cancer from recurring. The team tested their dual-action, cancer-killing vaccine in an advanced mouse model of the deadly brain cancer glioblastoma, with promising results. Findings are published in Science Translational Medicine.
“Our team has pursued a simple idea: to take cancer cells and transform them into cancer killers and vaccines,” said corresponding author Khalid Shah, MS, PhD, director of the Center for Stem Cell and Translational Immunotherapy (CSTI) and the vice chair of research in the Department of Neurosurgery at the Brigham and faculty at Harvard Medical School and Harvard Stem Cell Institute (HSCI). “Using gene engineering, we are repurposing cancer cells to develop a therapeutic that kills tumor cells and stimulates the immune system to both destroy primary tumors and prevent cancer.”
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Dual-Action, Cancer Killing Vaccine
Scientists developed a bifunctional therapeutic strategy by transforming living tumor cells into a therapeutic. Shah’s team engineered living tumor cells using the gene editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agent. In addition, the engineered tumor cells were designed to express factors that would make them easy for the immune system to spot, tag and remember, priming the immune system for a long-term anti-tumor response. The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTC) in different mice strains including the one that bore bone marrow, liver and thymus cells derived from humans, mimicking the human immune microenvironment. Shah’s team also built a two-layered safety switch into the cancer cell, which, when activated, eradicates ThTCs if needed. Credit: Kok Siong Chen and Khalid Shah
********************************************** Cancer vaccines are an active area of research for many labs, but the approach that Shah and his colleagues have taken is distinct. Instead of using inactivated tumor cells, the team repurposes living tumor cells, which possess an unusual feature. Like homing pigeons returning to roost, living tumor cells will travel long distances across the brain to return to the site of their fellow tumor cells. Taking advantage of this unique property, Shah’s team engineered living tumor cells using the gene-editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agent. In addition, the engineered tumor cells were designed to express factors that would make them easy for the immune system to spot, tag, and remember, priming the immune system for a long-term anti-tumor response.
The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTC) in different mice strains including the one that bore bone marrow, liver and thymus cells derived from humans, mimicking the human immune microenvironment. Shah’s team also built a two-layered safety switch into the cancer cell, which, when activated, eradicates ThTCs if needed. This dual-action cell therapy was safe, applicable, and efficacious in these models, suggesting a roadmap toward therapy. While further testing and development is needed, Shah’s team specifically chose this model and used human cells to smooth the path of translating their findings for patient settings.
“Throughout all of the work that we do in the Center, even when it is highly technical, we never lose sight of the patient,” said Shah. “Our goal is to take an innovative but translatable approach so that we can develop a therapeutic, cancer-killing vaccine that ultimately will have a lasting impact in medicine.” Shah and colleagues note that this therapeutic strategy is applicable to a wider range of solid tumors and that further investigations of its applications are warranted.
Reference: “Bifunctional cancer cell-based vaccine concomitantly drives direct tumor killing and antitumor immunity” by Kok-Siong Chen, Clemens Reinshagen, Thijs A. Van Schaik, Filippo Rossignoli, Paulo Borges, Natalia Claire Mendonca, Reza Abdi, Brennan Simon, David A. Reardon, Hiroaki Wakimoto and Khalid Shah, 4 January 2023, Science Translational Medicine. DOI: 10.1126/scitranslmed.abo4778
Disclosures: Shah owns equity in and is a member of the Board of Directors of AMASA Therapeutics, a company developing stem cell-based therapies for cancer.
Funding: This work was supported by the National Institutes of Health (grant R01-NS121096).
Don’t trust any Big Pharma. Likely has mRNA buried deep within.
After the Covid-CDC-WHO fiasco, will anyone ever be able to trust a “ vaccine “ again ?
“CRISPR” isn’t always good news, and then there’s this:
Disclosures: Shah owns equity in and is a member of the Board of Directors of AMASA Therapeutics, a company developing stem cell-based therapies for cancer.
Funding: This work was supported by the National Institutes of Health (grant R01-NS121096
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The NIH and CRISPR have a tawdry history together. Whom to trust now that the NIH/CDC/FDA betrayed all Americans on a grand scale?
BrexitBen wrote: “After the Covid-CDC-WHO fiasco, will anyone ever be able to trust a “ vaccine “ again ?”
Bet you would if you had brain cancer and this would cure it.
BrexitBen wrote: “After the Covid-CDC-WHO fiasco, will anyone ever be able to trust a “ vaccine “ again ?”
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Dugway$$ wrote:
Bet you would if you had brain cancer and this would cure it.
NOT if it CAUSES it!
🙃
A good friend passed New Year day from that mioblastoma (?)brain thing. 🙏😥
But you’re going to trust this “miracle” vaccine too?
Um...no I wouldn’t...
Glioblastoma is a death sentence.
Big pharma can make things that will save your life or sell expensive snake oil.
The former is great and unique. The latter is ubiquitous in all areas of business.
“After the Covid-CDC-WHO fiasco, will anyone ever be able to trust a “ vaccine “ again ?”
Normal people.
People who aren’t locked into some Anti-Vaxx, Q-Anon paranoid conspiracy mentality.
People who get flu vaccines, people who get shingles vaccines.
People who have their kids vaccinated against mumps, measles, whooping cough (in other words those who don’t ride on the backs of responsible people in order to keep their kids safe).
Any yes, it’s funny to watch people who don’t seem to know a damn thing about this brain cancer vaccine ranting against it.
Self Replicating nanites tagged to virus or mRNA is not new. Once injected you are a pawn of the weaponized medical industry.
Vaccines that have a detailed history are quite acceptable.
Cell therapies that have necessitated the change of the definition of “Vaccine” that are both experimental and suspect (VAERS) are not acceptable.
If you disagree with this, YOU’RE the ASSHOLE. Get me?
Paging “I Am Legend” on the white courtesy phone.
The vaccine works by training the immune system to prevent cancer from returning.
Just like the successful covid gene therapy did... riiiggghhhtttttt.
Mrs. Dutch Boy was diagnosed with a massive glioblastoma multiforme WHO Grade IV unmetylated tumor over 18 months ago. It measured 6.3cm x 4.4cm x 5.3cm. She did the standard resection, radiation and Temodar chemo. I also started her in 222mg of fenbendazole with 1200mg of Bioavailble Curcumin. It killed the remaining 5mm tumor that resection didn’t get. She has been cancer free ever since.
Praise the Lord!!
Thank you for sharing….may she continue to have this wonderful report!!
I was given a pointer to fenbendazole by someone on FR. I am just sharing when I can.
Yes....there have been several threads about the success of using it.
It is just wonderful to hear feedback.
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