Posted on 07/03/2023 10:21:48 AM PDT by ConservativeMind
In a new large, comprehensive analysis that looked at data from more than 5 million patients, the Martin/Hopkins method developed by Johns Hopkins researchers to calculate low-density lipoprotein (LDL) cholesterol—so-called bad cholesterol—produces higher accuracy rates than the nearly two dozen other available equations.
The findings reveal that overall, the Martin/Hopkins algorithm correctly classified 89.6% of patients' LDL cholesterol values, followed by the Sampson method, which correctly classified 86.3%. The previous gold standard of testing LDL cholesterol levels, the Friedewald method, correctly classified 83.2% of patients. An even larger advantage of the Martin/Hopkins algorithm was seen over other methods for patients with characteristics such low cholesterol and high triglyceride levels.
Analyzing 23 identified LDL cholesterol equations, the researchers found that following the Martin/Hopkins equation, those with the most accurate findings were Sampson, Chen (84.4%), Puavilai (84.1%), Delong (83.3%) and Friedewald. The other 17 equations were less accurate than Friedewald, with accuracy as low as 35.1%.
High levels of LDL cholesterol are associated with buildup of plaque in the arteries that can narrow the blood vessels and restrict blood flow to the heart and the brain, which can lead to heart attack and stroke.
Before Martin/Hopkins was developed, the Friedewald equation was the most commonly used method to gauge LDL cholesterol. However, Martin says that method and others that followed underestimate LDL cholesterol and cardiovascular disease danger for people for whom accuracy matters most: those at high risk.
Johns Hopkins Medicine has made the Martin/Hopkins method publicly available, and any lab can use it for free. It can be accessed at LDLcalculator.com.
(Excerpt) Read more at medicalxpress.com ...
The next best algorithm, the Sampson, has a prior study showing it was best used with high triglyceride people (and more accurate than Martin/Hopkins with those individuals), but this study is showing the formulas are neck-and-neck for accuracy and enough better than the normal Friedewald method to make it worth plugging in your numbers to get a likely more accurate LDL number for you. The Sampson formula is not proprietary and is free for all use.
What was really nice was the original paper (free) has a supplement file that gives you the formulas. I’ll post that link, next.
The study supplement, with the formulas (including Sampson):
https://storage.googleapis.com/jnl-up-j-gh-files/journals/1/articles/1214/6490448c661fc.pdf
The Excel spreadsheet for non-commercial use (appears to be free to use by doctors and patients, but not for sale purposes):
#1 there 5 different kinds of LDL chloresterol and only the small dense small particle is one of any demerit.
#2 The HDL and triglyceride count is a much more accurate picture of blood health.
#3 Chloresterol was a non factor before the 70's when Big Pharma found a way to lower LDL chloresterol (the larger fluffier benign kind). Now the AMA and every doctor is a sales rep for Pfizer to sell statins.
#4 Smoking, obesity chronic inflamation (from 2 diabetes and metabolic syndrome and hypertension are much more risk factors for Cardiac problems than chloresterol.
Associate research is the lowest level of research and one cannot reliably base a prognosis or any conclusion on it alone.
I agree. I just finished reading two books on cholesterol: “The Cholesterol Myth”and The Cholesterol Hoax.” Very eye-opening. As you stated, the problem is inflammation and also too much sugar intake.
Every hormone we have is derived from cholesterol. Does it really make sense to reduce the amount of the mother of our hormones? That, to me, flies in the face of all of the cholesterol existential lies we have been inundated with for the last 50 years or so.
My doctor wants me to go on a statin, but I have refused to do that so far, and will refuse to do that in the future. My cholesterol has been between 250 and 300 for years. I am 72 years old, and am in excellent health. You would have thought with that high of a level I would have been dead long ago.
Another interesting thing that was in the second book was the discussion of statin use and diabetes. As it turns out a statin will force your liver to push sugar into your bloodstream. So now you are essentially diabetic. So you go to your doctor, and the doctor wants to put you on a diabetic drug. So now you are on two drugs instead of just one. It is pretty much downhill from there.
23% of your chloresterol is in your brain. What happens to that chloresterol if the statin passes the blood brain barrier? The chloresterol in the brain insulates your neurons from one another in a sheathing. Alzheimers and dementia may have a connection with statins so that’s one reason I’ll never take them. The real solution is to clean up the diet and get off of the sugar (which is in almost everything processed).
bttt
AGAIN. LDL cholesterol is not a problem. Neither is HDL cholesterol. Both are required in abundance for human life.
The only bad cholesterol are CLDL cholesterol, and they are not really cholesterol at all. CLDL cholesterol are dead shells of cholesterol which a glycated liver fails to fill with acetone. This failure comes when the patient consumes a diet too rich in fructose (anything which tastes sweet).
The differences between people’s LDL-to-HDL ratios are caused by inborn APoE genetics and mean very little to health outcomes.
When a liver fails to fill cholesterol particles it leaves the unused acetone in the bloodstream as “triglyceride”. Have your triglyceride levels checked if you suspect a problem.
Dr Ken Berry, M.D, of Nashville, who has 20 plus years of experience says that HIGH cholesterol is not nearly as concerning as having a HIGH TRIGLYCERIDE reading. He explodes the myth about cholesterol. See for yourself.
How to Raise Your HDL & Lower Your Triglycerides (NOT what you Think) - 7:47
Also from Doc Berry:
How to NOT DIE from a Heart Attack [Risks for Heart Attack] 2023
https://www.youtube.com/watch?v=BIg8A_i4hhI
If you’re impatient, skip ahead to about 7:50.
Spoiler alert: LDL is #8 on the list of risk factors for heart attack.
Bingo.
Same here. This reminds me of my old supervisor who was on statins. He kept feeling poorly so he went in for a full physical. He did the treadmill and everything. He passed with flying colors! His chloresterol was spot on. Him and the doctor were happy. A week later he died of a massive heart attack at home at the dining room table in front of his wife. ONE week after a "successful" physical. I'll never forget that.
Makes you wonder if things like dementia and Alzheimer’s are due to the statin frenzy. Obviously, if that percentage of cholesterol is in your brain, why would you want to lower your cholesterol? Seems like that would have a negative effect not only on your brain but on every cell in your body!
Why think such negative thoughts when there are profits to be made for Big Pharma? Slow killing the surplus population and making more money suits the globalists plans just right. They are dreaming up the next bioweapon and “cure” right now. You can bet your bottom dollar on it.
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