Posted on 12/03/2023 8:58:43 PM PST by ConservativeMind
New insights into the pathogenesis of Alzheimer's disease could unlock novel therapeutic approaches and help to prevent the disease. A study has shed light on a bidirectional interaction in the body's fat metabolism that could play an important role in the development of the disease. Dietary and other lifestyle factors such as smoking also play a role.
One protein that is known to play a key role in Alzheimer's disease is the amyloid-beta peptide.
"This small amyloid-beta protein accumulates in the form of hardened plaques within a patient's brain. Amyloid-beta is a key element in the development of Alzheimer's and leads to neurodegeneration," explains nutrition specialist Grimm.
The team has succeeded in identifying a previously unknown mechanism in the body's fat metabolism that can lead to the development of Alzheimer's.
They discovered that the production of the amyloid-beta protein influences the synthesis of certain fats, particularly a class of lipids known as sulfatides, and, conversely, that the quantity of sulfatides mediates the amount of amyloid-beta. This bidirectional interaction is of potentially major significance in Alzheimer's research, as the level of sulfatides is known to be depleted and the level of amyloid-beta elevated in the brains of Alzheimer's patients.
"We have been able to demonstrate experimentally that amyloid-beta production influences the amount of sulfatides and vice versa," said Grimm.
Of particular interest to the researchers is the impact that diet and lifestyle may have on the disease. "Factors such as smoking can have a negative effect on sulfatide levels, whereas ensuring the body has an adequate supply of vitamin K or eating certain types of seafood can have a positive effect. These findings suggest possible approaches to developing preventive and therapeutic strategies in the fight against Alzheimer's disease," said Hartmann.
(Excerpt) Read more at medicalxpress.com ...
“…ensuring the body has an adequate supply of vitamin K or eating certain types of seafood can have a positive effect (on sulfatide levels).”
Thanks for posting this.
Vitamin K-2 is also important to take with vitamin D3.
Yup.
I’ve been taking a barrage of vitamins for years and at 61 having beaten cancer and after-effects I have to say the vitamins (along with staying fit) made the difference between life or death. Have added glucosomine for the joints which helps a lot.
Yep, hard to roll them without glucosomine - to get that joke out of the way. Dave’s not here man.
I’m looking at a Vit K football in my daily supplement pile. Yay!
BTW, thanks for these, I haven’t said that in a while. I do look at them.
I read an earlier article you posted about a super k supplement. One of the guys reposted it on an earlier thread.
That guy said the fluffy ldl is good for you bud the hard dense ldl is bad for you. Trouble is the regular tests you get don’t distinguish between the two. The hard dense ldl will fluff out on a keto diet.
He also mentioned that much higher levels of vitamin k are desireable and so far no upper limits have been found
Thank you so much for your postings. I enjoy them and learn from them. They often coincide with things I find independently. I am going to make an observation though. I am having difficulties with the Med-express articles. There seems to be lots of conjecture and not hard, scientific conclusions. “May, maybe, might, could, in the future might lead...” Bombshells that could be duds. Maybe it is just me.
Koncentrated K has the highest, and I alternate that with Life Extensions Super K.
I see a lot of back and forth between which is better k2 mk4 or mk7.
Nearly everything I post from there has the formal research paper attached.
It’s at the bottom in the credit area, already linked to the abstract, which lets you choose a PDF or web version.
This is breaking news from the most recent studies to be published. I am posting summaries, which is what winds up at various places like Medical Xpress, Science Daily, etc.
Due to these being “hot off the press,” many papers speak to the expectation that decades of future studies, with double-blind placebos, need to occur, for enough for a few meta studies that can then tell that something can be considered “helpful.
You can wait 20-30 years, or try what is known, today, with more potential risk around it.
Those supplements have both.
I suspect it's K2, as here is a related article...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308377/
I personally prefer MK Ultra...
Thank you!
The article fails to mention that in Alzheimer's, the amyloid-beta is altered; not normal. When mice with MS are injected with good amyloid-beta, their MS is cured within two weeks.
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