What is working now: Covid-19

David Sinclair, PhD AO @davidasinclair

Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19. What follows is a thread of information, my interpretation, links to sources & predictions. Let's start with what you need to know... #coronavirus #COVIDー19

Treatments that seem to work are chloroquine (a cheap malarial drug), Gilliad's remdesivir with interferon-beta (in clinical trials from COV-19), plasma from recovered patients, and a steroid (methylprednisilone). Doctors in US are now using remdesivir off-label...

SARS-CoV2 attacks pneumocytes in lung, intestine, heart & cells lining blood vessels. In lung, CoV2 prevents cells from making biological detergents to keep lung passages open. Acute respiratory distress follows. O2 levels fall..but there's may be a dangerous underlying process.. ..new work out of China yesterday says COVID-19 might also involve abnormal blood production. CoV genes 1 & 8 are predicted to interfere with heme, the red compound in blood, by kicking out the iron. Would explain why chloroquine seems effective as a treatment #CoronaVirusUpdate

Chloroquine is predicted to prevent orf1ab, ORF3a and ORF10 from attacking heme (red in red blood cells) and inhibit the binding of ORF8 to heme. Although 99% of the virus is seemingly stable, what's disturbing is ORF 1 and 8 are mutating the fastest...

..Positions nt28144 in ORF 8 and nt8782 in ORF1 are evolving. Samples out of China show they'd mutated 30.53% (29/95) and 29.47% (28/95), respectively. I'm currently figuring out why these are the ones mutating and how that would change the situation...

It may explain why diabetics and elderly are more susceptible. Blood sugar levels usually increase as we get older, increasing the amount of glycated hemoglobin (HbA1c) (I've tweeted about this before). The authors suggest these people would be more susceptible to because... ...the virus could more easily disrupt the heme in red blood cells. If so, the virus is very smart: it destroys the lung so patients can't take up oxygen AND reduces the body's ability to carry oxygen. (For this & other reasons, you should eat healthily the next 2 years)...

These ideas are testable. COVID-19 should correlate with HbA1c levels (seems true). Patients should have abnormalities in heme/porphyrin & they might have higher levels of free iron in tissues & blood. I will update with more info as it comes in. Stay safe. Below are links... Blood, HbA1c, and chloroquine COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin https://tinyurl.com/w28et45

CoV2 mutations tinyurl.com/secncmf Symptoms tinyurl.com/ubncbgn Susceptibility/Risk tinyurl.com/vexo5vl Fatality tinyurl.com/sb8qpza Therapies tinyurl.com/vrm7f5j Remdesivir

Wow, my blood type is AB positive which makes me a near “universal” plasma donor. The could order me and others with AB positive blood type back to active duty, infect us with Wuhan Coronavirus and, once (if) we recovered, make us regular plasma donors. Hell, we’d solve the whole damn problem ... or at least mitigate it.

Tonic water and zinc

South Korea was having success with the malaria drug and zinc

Interesting. Thanks for posting.

I don’t think there is any quinine in tonic water anymore

Just had my A1C done: 6.9
Good timing on my part.

CC

Bkmrk

I keep getting a feeling this is man made. a malaria cocktail to resolve a cold air flu virus.

” (For this & other reasons, you should eat healthily the next 2 years).”

Meaning what?

6.9 A1C is diabetic. Are you being treated?.

Normal up to 5.7
Prediabetic 5.7-6.4
Diabetic 6.5 and higher.

(My last few A1C’s have been at 5.7 which isn’t an issue). But, that’s where I pulled the range numbers from.

I’ve read about this theory elsewhere as well. But, I’ve Also read (in regards to this virus) about Vit D, cytokine storms, avoiding elderberry, nose hairs/vs no nose hairs - to name a few. There’s so much medical discussion out there.

I keep getting a feeling this is man made. a malaria cocktail to resolve a cold air flu virus.

Your concerns are warranted. I wonder the same. I watched a video conference of some gene-splicing scientists who were experimenting with creating life by building RNA stands from simple sugars. Not just splicing together living cell components, but actually trying to build a cell from A, C, G, T chemicals derived from sugars. They were trying to kick-start life and have the cells reproduce. This had nothing to do with virus creation. More to do with eliminating the middle-man in creating goods, which is what living creatures do. Mimicking plants and animals ability to create foodstuffs, and just growing the end-products in a lab from man-made cells.

Anyway, one of their concerns was about contamination from an outside virus spoiling the man-made cells, and mutating it to something destructive that gets into the outside world. The video was from four years ago. And that was about scientists working on good purposes; there are other scientists using the same technology for not so good purposes!

So yes, what if this new virus was purposely man made? (Just speculation at this point.)

I’m going to guess that means less sweets and to watch the sugar in your blood levels

Makes me think about how my AML leukemia actually changed my DNA. It translocated the (4,12) chromosome . (As well as acquiring a couple of mutations). After remission from chemo/treatment, the effected chromosomes went back to normal .

While I’m very much leaning towards this virus being made in the lab, I personally experienced how nature can do some strange things.

“I don’t think there is any quinine in tonic water anymore”

Sure it does, at least the Schweppes in my Fridge does, says it right on the label. Medicinal amount is a big unknown? Quinine is what gives Tonic water the unique flavor.

Doctors in US are now using remdesivir off-label

Someone with a "Harvard lab" ought to know what "off-label use" means.

Just an update to what I mentioned above. Quinine and chloroquine are not the same thing / drug.

https://wikidiff.com/chloroquine/quinine

mark

“Someone with a “Harvard lab” ought to know what “off-label use” means”

Remdesivir is in phase III testing, it’s not even available to prescribe off label. NIH is using it to test efficacy in Corona patients in limited use at a Nebraska Hospital (China / Japan testing as well) At some point I imagine if the drug shows promise Doctors can request to prescribe via Compassionate Use prior to final FDA approval.

“I don’t think there is any quinine in tonic water anymore”

Tonic water contains 83mg per liter.