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Green Tea may Reduce Inflamation and Increase Physical Endurance
Am J Physiol Regul Integr Comp Physiol

Posted on 01/27/2005 7:59:06 PM PST by Coleus

Am J Physiol Regul Integr Comp Physiol (November 24, 2004). doi:10.1152/ajpregu.00693.2004

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Submitted on October 7, 2004
Accepted on November 20, 2004

Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice

Takatoshi Murase1*, Satoshi Haramizu1, Akira Shimotoyodome1, Azumi Nagasawa1, and Ichiro Tokimitsu1

1 Biological Science Laboratories, Kao Corporation, Haga-gun, Tochigi, Japan

* To whom correspondence should be addressed. E-mail: murase.takatoshi@kao.co.jp.

Green tea contains a high level of polyphenolic compounds known as catechins. We investigated the effects of green tea extract (GTE), which is rich in catechins on endurance capacity, energy metabolism and fat oxidation in Balb/c mice over a 10 week period. Swimming times to exhaustion for mice fed 0.2% - 0.5% (w/w) GTE were prolonged by 8% - 24% and the effects were dose dependent, and accompanied by lower respiratory quotients and higher rates of fat oxidation, as determined by indirect calorimetry. In addition, feeding with GTE increased the level of {beta}-oxidation activity in skeletal muscle. Plasma lactate concentrations in mice fed GTE were significantly decreased after exercise, concomitant with increases in free fatty acid concentrations in plasma, suggesting an increased lipid utilization as an energy source in GTE -fed mice. Epigallocatechin gallate (EGCG), a major component of tea catechins, also enhanced endurance capacity, suggesting that the endurance-improving effects of GTE were mediated, at least partly, by EGCG. The {beta}-oxidation activity and the level of fatty acid translocase (FAT/CD36) mRNA in the muscle was higher in GTE-fed mice compared to control mice. These results indicate that GTE are beneficial for improving endurance capacity and support the hypothesis that the stimulation of fatty acid utilization is a promising strategy for improving endurance capacity.

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INFLAMMATION/IMMUNITY/MEDIATORS

Green tea polyphenol (–)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-{gamma} but not by IL-4

James L. Watson, Sara Ansari, Heather Cameron, Arthur Wang, Mahmood Akhtar, and Derek M. McKay

Intestinal Disease Research Programme, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5

Submitted 17 July 2003 ; accepted in final form 23 June 2004

A characteristic of many enteropathies is increased epithelial permeability, a potentially pathophysiological event that can be evoked by T helper (Th)-1 (i.e., IFN-{gamma}) and Th2 (i.e., IL-4) cytokines and bacterial infection [e.g., enteropathogenic Escherichia coli (EPEC)]. The green tea polyphenol (–)-epigallocatechin gallate (EGCG) has immunosuppressive properties, and we hypothesized that it would ameliorate the increased epithelial permeability induced by IFN-{gamma}, IL-4, and/or EPEC. EGCG, but not the related epigallocatechin, completely prevented the increase in epithelial (i.e., T84 cell monolayer) permeability caused by IFN-{gamma} exposure as gauged by transepithelial resistance and horseradish peroxidase flux; EGCG did not alleviate the barrier disruption induced by IL-4 or EPEC. IFN-{gamma}-treated T84 and THP-1 (monocytic cell line) cells displayed STAT1 activation (tyrosine phosphorylation on Western blot analysis, DNA binding on EMSA) and upregulation of interferon response factor-1 mRNA, a STAT1-dependent gene. All three events were inhibited by EGCG pretreatment. Aurintricarboxylic acid also blocked IFN-{gamma}-induced STAT1 activation, but it did not prevent the increase in epithelial permeability. Additionally, pharmacological blockade of MAPK signaling did not affect IFN-{gamma}-induced epithelial barrier dysfunction. Thus, as a potential adjunct anti-inflammatory agent, EGCG can block STAT1-dependent events in gut epithelia and monocytes and prevent IFN-{gamma}-induced increased epithelial permeability. The latter event is both a STAT1- and MAPK-independent event.

intestinal barrier; permeability; T84; signal transducer and activator of transcription-1


Address for reprint requests and other correspondence: D. M. McKay, Intestinal Disease Research Programme, McMaster Univ., HSC-3N5C, 1200 Main St. West, Hamilton, ON, Canada, L8N 3Z5 (E-mail: mckayd@mcmaster.ca)


TOPICS: Health/Medicine; Science
KEYWORDS: egcg; endurance; greentea; health; inflamation; nutrition; science; supplements; vitamins

1 posted on 01/27/2005 7:59:06 PM PST by Coleus
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To: Coleus; Chieftain

You mean diet Coke won't work?

I'm sure Green tea is good...but couldn't follow this.


2 posted on 01/27/2005 8:22:16 PM PST by Recovering Ex-hippie (Everything I need to know about Islam, I learned on 9-11!)
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To: Recovering Ex-hippie

I don't drink tea..ANY tea (only if some maiden aunt pushes it on me)...and I don't drink coffee either.

You think I should start?


3 posted on 01/27/2005 8:24:39 PM PST by Happygal (liberalism - a narrow tribal outlook largely founded on class prejudice)
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To: Coleus

Green tea makes your blood thick.


4 posted on 01/27/2005 8:26:43 PM PST by BJungNan (National sale tax - end all this insane tax records paperwork.)
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To: Happygal

I am totally addicted to coffee...I need the caffeine so I don't fall asleep listening to the Dims blathering.


5 posted on 01/27/2005 8:29:19 PM PST by Recovering Ex-hippie (Everything I need to know about Islam, I learned on 9-11!)
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To: Coleus
A characteristic of many enteropathies is increased epithelial permeability, a potentially pathophysiological event that can be evoked by T helper (Th)-1 (i.e., IFN-) and Th2 (i.e., IL-4) cytokines and bacterial infection [e.g., enteropathogenic Escherichia coli (EPEC)].

(Slapping myself on the forehead).

Of course!

6 posted on 01/27/2005 8:29:46 PM PST by Larry Lucido
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To: Temple Owl

ping


7 posted on 01/27/2005 8:31:08 PM PST by Tribune7
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To: Recovering Ex-hippie

Oh, I will drink a cup of java, now and then...

..but I would say, I've not had a single cup of coffee in 2005.


8 posted on 01/27/2005 8:32:57 PM PST by Happygal (liberalism - a narrow tribal outlook largely founded on class prejudice)
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To: Coleus

bttt


9 posted on 01/27/2005 8:34:52 PM PST by nopardons
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To: Recovering Ex-hippie

I prefer diet pepsi myself.

You can take egcg in pill form or in a dropper mixed with water.


10 posted on 01/27/2005 9:47:38 PM PST by Coleus (Abortion and Euthanasia, Don't Democrats just kill ya! Kill babies, Save the Bears!!)
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To: Larry Lucido

Of course! >>

Yea, who would have thought. Have a medical dictionary handy?


11 posted on 01/27/2005 9:49:05 PM PST by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, birds, algae)
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To: Coleus

Wow... This is a tough one to follow. I have heard that green tea is good for many things, but I would love to see this in laymans language.


12 posted on 01/27/2005 9:53:38 PM PST by Irish Eyes
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To: Irish Eyes; Larry Lucido
EGCG & OPC Antioxidant Reference Guide: Oligomeric Proanthocyanidins (OPC's)

EGCG - potent extract of green tea

Green Tea Health Benefits

Green Tea Extract - Green Tea Extract Health Benefits

13 posted on 01/27/2005 10:11:34 PM PST by Coleus (What was Ted Kennedy and his nephew doing on Good Friday in 1991? Getting Drunk and Raping Women)
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To: Coleus

Thanks, These are some good links :)


14 posted on 01/27/2005 10:18:40 PM PST by Irish Eyes
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To: Coleus

So, are these "green tea" tea bags I got a Walgreen any good, or am I just kidding myself?


15 posted on 01/27/2005 10:29:23 PM PST by Larry Lucido
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To: Larry Lucido
It would be best to buy the "green tea extract" or EGCG in a health food store.
 
Green Tea Extract
 
Green tea : by Ray Sahelian, MD, Green tea health benefits
 
Green Tea Extract ( EGCG) , Source Naturals, 500 mg, 120 Tabs
 
SIZE
2 Fluid Ounces
Liquid
SERVING
SIZE
2 ML
 
Read about it in our Health Guides
 
 

16 posted on 01/27/2005 10:40:55 PM PST by Coleus (There is Plenty of Room For all of God's Creatures, Right Next to the mashed potatoes!)
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To: Coleus

17 posted on 01/28/2005 1:01:43 AM PST by ajolympian2004
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To: Coleus

18 posted on 01/28/2005 1:02:47 AM PST by ajolympian2004
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To: Recovering Ex-hippie

I LOVE traditional Japanese ocha (green tea) piping hot. I also love traditional Japanese cold tea (mugicha) in the summer. The stuff in replys 17 and 18 is good too! I will stop by the store this afyernoon and get a few bottles. Thanks for bringing this to my attention!


19 posted on 01/28/2005 3:26:59 AM PST by Chieftain (Thank you Swift Boat Veterans/POWs/Vietnam Veterans for Truth - you did it for ALL your brothers!)
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To: Coleus
A must read on this topic (IMO):

http://www.ajcn.org/cgi/content/abstract/80/6/1558

"Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement"

This study was done using the Pharmanex Tegreen 97 product. I use this (and believe in it). The distributor's price is $13.30 US + s/h for a 30 day supply and it is 97% polyphenols (250 mg, 20:1 extract).

Private Message me if you're interested.
20 posted on 02/02/2005 11:11:58 AM PST by critical_phil
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To: critical_phil

how much egcg is in it?


21 posted on 03/14/2005 8:03:31 PM PST by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, birds, algae)
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