Virus infections may be contributing factor in onset of gluten intolerance

Academy of Finland ^ | Mar 5, 2010 | Unknown

[decimon]

Cassandra ping.

[hennie pennie]

*ping*

[blackpacific]

Thanks for posting. I noticed they did not give the name of the gene in question? Dogtor J, John Symes DVM, has an interesting theory about viruses and immune response.

Try www.dogtorj.com

Cheers.

[TruthWillWin]

gluten intolerance

How does one know if your computer has this?

[hennie pennie]

*ping*

[Carpe Cerevisi]

This may prove to be helpful:

http://www.celiac.com/articles/1046/1/Understanding-the-Genetics-of-Gluten-Sensitivity-by-Dr-Scot-Lewey/Page1.html

[conservativeharleyguy]

It won’t let you load Toast....

[TexasRepublic]

“How does one know if your computer has this?”

Core dumps from a port on the rear panel.

[Smokin' Joe]

Ping...(Thanks, hennie pennie!)

[metmom]

My understanding is that something like that can cause lactose intolerance as well.

My daughter developed lactose intolerance after having her appendix out and it has gradually cleared up.

My sister had it for a few years and it went away on it’s own as well.

It wouldn’t surprise me that other intolerances are a result of a disturbance of the intestines.

[trisham]

Thanks for the ping! I just forwarded the link to my sister, who has celiac disease.

[Myrddin]

Lactose intolerance was the initial outward expression of gluten intolerance in my case. Lactase is generated on the tips of the cilia of the small intestine. Exposure to gluten damages the cilia. The tips are damaged first. The absence of lactase is experienced with acid, gas and abdominal cramps as the bacteria (typicall E. Coli) convert lactose to acid and gas.

Gluten intolerance includes versions of proteins that bind to the gliaden protein component of gluten. It is bound in a manner that optimally exposes the antigenic surface for the immune system to mount an immune response. In addition, the cells of the small intestine normally have "tight junctions" to limit passage of large particles into the blood stream. In gluten intolerant individuals, the immune response to gliaden provokes expression of "zonulin". The zonulin protein turns the tight junctions into "loose junctions". Larger particles in the digestive tract can pass into the blood stream. That expands the possibilities for expose of more antigens to the immune system.

There is a variant of the casein protein in Holstein sourced cow's milk that produces peptides with a morphine like structure when hydrolyzed by digestive enzymes. In a gluten intolerant individual, this morphine like substance can pass into the blood and produce a narcotic impact on the brain. The simple fix is to avoid gluten and dairy. Sometimes it is not so easy. Unintended exposure leads to a few days of extended trips to the "reading room".

[blackpacific]

There is a fascinating discovery of the difference between the A1 beta-casein variant, and the A2 beta-casein variant, as chronicled in the book “The Devil in the Milk” by Kenneth Woodward. Some line of cattle have A2 capability, but most have A1. Since it is a double allele thing, the possibilities are 100% A1, 50-50 A1 A2, or 100% A2. A2 milk is the ideal, which goats produce exclusively, but it can be bred into lines of cattle. BCM7 is the “devil” in our milk.

[neverdem]

genome-wide association study = GWAS, single nucleotide polymorphisms = SNPs

Multiple common variants for celiac disease influencing immune gene expression.

People with gluten intolerance and other associated malabsorption syndromes – such as celiac/coeliac disease, celiac sprue, non-tropical sprue, endemic sprue, gluten enteropathy, and gluten-sensitive enteropathy – have challenging dietary concerns.a>

[Mrs. B.S. Roberts]

“How does one know if your computer has this?”

it would feel ill when you crush wheat toast crumbs into the keyboard......sarc/

[Myrddin]

I purchased a quart of goat milk for our St. David's Day cooking on Monday. I've been using the balance in my coffee this week with no ill effects. A gluten free diet with goat's milk in place of cow's milk seems to be OK.

[SunkenCiv]

Maybe a virus is also behind the intolerance of the left wing? Thanks hp.

[Alamo-Girl]

Thanks for the ping!

[kitchen]

Goats milk makes excellent yogurt.