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Broccoli compound induces cell death in yeast, offers research path for cancer treatment
Phys Org ^ | 24 January 2022 | Hiroshima University

Posted on 01/24/2022 7:23:51 AM PST by Scarlett156

Broccoli may contain advantages beyond nutrition. A molecule found in broccoli, cabbage and more digests down into DIM, a compound with brighter benefits than the name implies, such as inducing cell death in breast, prostate and colon cancer. Now, researchers are beginning to understand the mechanism underpinning this molecular behavior—information that could help elucidate future anti-cancer treatments.

In a report published on Dec. 10, 2021, in PLOS One, Hiroshima University researchers summarize their finding that DIM, or 3,3'-Diindolylmethane, also triggers controlled whole-cell death and recycling of cellular components in fission yeast. Whether the DIM-induced damage mechanism is conserved in humans remains to be seen, but paper author Masaru Ueno explained that unicellular fission yeast allow for easier examination of molecular machinery that mimics behavior in more complex organisms.

"We discovered that the chemical compound, DIM, induces novel biological activity that damages the nuclear membranes in fission yeast," said Ueno, associate professor at Hiroshima Research Center for Healthy Aging, Graduate School of Integrated Sciences for Life, Hiroshima University.

The nuclear membranes enclose the cell's genetic information. Once the genetic material is replicated, the nuclear envelope, which comprises the inner and outer membranes, pinches into two and part, resulting in two cells where there once was one.

"Integrity of the nuclear membranes is important for human health," Ueno said. "Mutations that cause defects in the nuclear membrane accelerate aging. Nuclear membranes also rupture and repair themselves during cancer cell migration."

(Excerpt) Read more at phys.org ...


TOPICS: Food; Health/Medicine; Science
KEYWORDS: broccoli; cancer; diindolylmethane; health
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It's cute how the article doesn't explain what DIM is: It's the chemical diindolylmethane.

All joking aside, what exciting news for cancer research! (And for broccoli enthusiasts: I found a whole plethora of articles when I checked for posts with "broccoli" in the title. (Why am I hearing "James Bond" type music in my head now?)

1 posted on 01/24/2022 7:23:51 AM PST by Scarlett156
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To: Scarlett156

She’s choppin’ Broccoli!


2 posted on 01/24/2022 7:26:33 AM PST by dfwgator (Endut! Hoch Hech!)
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To: Scarlett156

“Fascinating”

I’ll add two more words:

“Gut health”


3 posted on 01/24/2022 7:27:39 AM PST by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: Scarlett156

Interesting article.

Anything that looks and tastes like broccoli has to be good for you. :)


4 posted on 01/24/2022 7:28:24 AM PST by Starboard
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To: dfwgator

5 posted on 01/24/2022 7:31:55 AM PST by Magnum44 (...against all enemies, foreign and domestic...)
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To: Starboard
Anything that looks and tastes like broccoli has to be good for you. :)

I'm a BIG fan of cabbage, just like me pappy -- purple cabbage in particular. I love cutting off a slice and munching on it. Tasty!

6 posted on 01/24/2022 7:36:52 AM PST by AnglePark
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To: Scarlett156

So broccoli is worse than cancer. My taste buds agree.


7 posted on 01/24/2022 7:41:40 AM PST by who_would_fardels_bear (This is not a tagline.)
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To: AnglePark

I don’t like cabbage but do like cole slaw.


8 posted on 01/24/2022 7:42:30 AM PST by Starboard
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To: Scarlett156

My wife and I take DIM.


9 posted on 01/24/2022 8:10:57 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email or private message me if you want on or off of this list.

10 posted on 01/24/2022 8:13:04 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Scarlett156

Eat your greens!


11 posted on 01/24/2022 8:23:24 AM PST by PGR88
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To: Scarlett156

is that with cheese or without?


12 posted on 01/24/2022 8:30:12 AM PST by Terry L Smith
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To: ConservativeMind

Where do you get DIM?

I do love broccoli and eat all I can......


13 posted on 01/24/2022 8:40:02 AM PST by Arlis
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To: Arlis

Amazon and Swanson Vitamins.


14 posted on 01/24/2022 8:45:37 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Scarlett156

Vile weed…


15 posted on 01/24/2022 8:49:33 AM PST by Magnatron
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To: Scarlett156

bookmark


16 posted on 01/24/2022 9:02:40 AM PST by GOP Poet (Super cool you can change your tag line EVERYTIME you post!! :D. (Small things make me happy))
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To: Scarlett156

So broccoli and cabbage cause your cells to die. So much for that vegan diet!


17 posted on 01/24/2022 9:06:21 AM PST by ProtectOurFreedom (81 million votes...and NOT ONE "Build Back Better" hat)
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To: ConservativeMind

My wife and I take DIM.


I have also, since about 2004.


18 posted on 01/24/2022 9:35:53 AM PST by Magic Fingers (Political correctness mutates in order to remain virulent.)
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To: dfwgator

I still won’t eat it!


19 posted on 01/24/2022 9:59:27 AM PST by ThePatriotsFlag (Lets Go Brandon.)
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To: Scarlett156
I eat broccoli every day....at least 12 ounces.

The benefits from broccoli can be gotten from other vegetables that were developed from the same 'wild cabbage' plant as broccoli.

CABBAGE

Cabbage, comprising several cultivars of Brassica oleracea, is a leafy green, red (purple), or white (pale green) biennial plant grown as an annual vegetable crop for its dense-leaved heads. It is descended from the wild cabbage (B. oleracea var. oleracea), and belongs to the "cole crops" or brassicas, meaning it is closely related to broccoli and cauliflower (var. botrytis); Brussels sprouts (var. gemmifera); and Savoy cabbage (var. sabauda).

20 posted on 01/24/2022 9:59:44 AM PST by blam
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