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Spike protein accumulates in the brain and causes infarcts, bleeds, inflammation - Pfizer & Moderna COVID-19 mRNA vaccines cause severe neurological injuries
Dr. William Makis MD ^ | 4/7/2023 | Dr. William Makis MD

Posted on 04/07/2023 6:52:37 PM PDT by george76

A new paper from Germany posted on April 5, 2023 proves that the spike protein accumulates in the brain and causes death of brain cells (which would certainly explain a great deal of what we see around us). (click here)

Key findings:

“Our results revealed the accumulation of the spike protein in the skull marrow, brain meninges, and brain parenchyma.”

“The injection of the spike protein alone caused cell death in the brain, highlighting a direct effect on brain tissue.”

“we observed the presence of spike protein in the skull of deceased long after their COVID-19 infection, suggesting that the spike’s persistence may contribute to long-term neurological symptoms”

Spike protein damage:

Out of all COVID-19 viral proteins, only the spike protein was detected in brain parenchyma.

“suggesting that the spike protein could have a long lifetime in the body. This notion is supported by the observation that spike protein can be detected on patient immune cells more than a year after the infection - a recent preprint suggests spike protein’s persistence in plasma samples up to 12 months post-diagnosis”

“injection of spike protein induced a broad spectrum of proteome changes in the skull marrow, meninges, and brain, including proteins related to coronavirus disease, complement and coagulation cascades, neutrophil degranulation, NETs formation, and PI3K-AKT signaling pathway, demonstrating the immunogenicity of SARS-CoV-2 spike protein in the absence of other viral components.”

Brain inflammation.

“Our molecular analysis suggests activation of immune response in the skull-meninges-brain axis, potentially via recruiting and increasing the activity of neutrophils similar to what has been reported in the respiratory tract”

“in the skull marrow…viral proteins act as an inflammatory stimulus that leads to the development of a significant immune response in the brain”

“In the meninges, a significant consequence of the inflammatory state is an upregulation of proteins involved in neutrophil degranulation”

“Proteins related to the neurodegeneration pathway and damage to the blood-brain barrier were the most prominent dysregulated molecules in the brain.”

“viral spike protein leads to the activation of RHOA, which triggers the disruption of blood–brain barrier”

Blood clots, mini-strokes, brain bleeds..

“The dysregulation of the complement and coagulation pathways was detected in both the skull marrow and the brain. This might explain the observed propensity of COVID-19 patients to develop mini-infarcts in the brain parenchyma and our observation of an increased level of micro-bleedings in COVID-19 patients, potentially contributing to the observed brain damage in the COVID-19 patients in acute or chronic stages”

Spike protein and Neurological diseases..

“We identified several candidate proteins with no previous association with COVID-19, especially those earlier associated with neurological diseases…notably, their role has been associated with disorders such as Parkinson’s disease, Alzheimer’s disease, and dementia”

“To further pinpoint the consequences of spike protein-specific effects in the brain tissue beyond the acute inflammatory response…We identified several dysregulated proteins associated with neurodegeneration”

“significantly impairs mitochondrial function…a source of oxidative stress reported in…long-term symptoms such as chronic fatigue”

How Spike protein gets into the brain..

“Our data may also suggest a mechanism for the virus’s entry into the central nervous system. In both mouse and COVID-19 human tissues, we find spike protein in the SMCs (skull-meninges connection), which the virus or virus components could use to travel from the skull marrow to the meninges and the brain parenchyma”

“virus might take other routes to reach the brain in a not mutually exclusive way. For example, the virus could traverse the cerebrovasculature to reach the brain parenchyma or be carried there by immune cells (via neutrophils or phagocytic cells)”

“Brain invasion of virus-shed spike protein found in some COVID-19 cases has been linked to a compromised blood-brain barrier and trafficking along the olfactory nerve or vagus nerve. Here, we suggest an alternative scenario wherein SARS-CoV-2 spike protein reaches first the skull marrow and then the meninges before entering the brain.”

“Spike-induced alterations in the skull-meninges-brain axis present diagnostic and therapeutic opportunities as both skull and meninges are easier to access than brain parenchyma”

My substacks on psychosis post COVID-19 vaccination:

March 9, 2023 - Children who were injured by Pfizer or Moderna COVID-19 mRNA vaccines - Hallucinations, self-harm, suicide attempts, permanent disability (click here)

March 8, 2023 - COVID-19 vaccine induced psychosis - 13 cases of post vaccine psychosis, mania & suicide attempts that will shock you..

My Take…

This is an extremely important paper from Germany (we will never see this kind of research done in Canada).

This paper proves that the SARS-CoV2 and COVID-19 mRNA vaccine spike protein enter the skull marrow, meninges and the brain parenchyma.

The spike protein disrupts the blood brain barrier.

The spike protein alone causes cell death in the brain, it activates complement and coagulation pathways that lead to blood clots, mini infarcts and brain bleeds, it causes inflammation, and local changes associated with neurodegeneration (dementia, Alzheimer’s, Parkinson’s Diseases).

I believe that neurological injury is one of the biggest categories of COVID-19 mRNA vaccine injury. These injuries are extremely common, and we have only begun to see the long term effects of spike protein accumulation in the brain.

Beyond the strokes, aneurysms and brain bleeds, the vision and audiovestibular problems, all kinds of paralysis and movement disorders, I believe that among the COVID-19 mRNA vaccinated, we will see a huge spike in neurodegenerative disorders, mental health disorders and an overall increased risk of suicide.


TOPICS: Conspiracy; Health/Medicine; Science; Weird Stuff
KEYWORDS: adverseevents; ama; bigpharma; bigpharmatrollshere; bioweapon; bloodclots; brain; brainbleeds; braincells; chinavirus; chinavirusvaccine; covid19; death; deathjabs; deathshots; ecg; ekg; electrocardiogram; experimental; faa; frindecline; genetherapy; germany; getsumlearnin; heartinflammation; ivermectin; mediumrare; mediumwell; mrna; mrnagenetherapy; myocarditis; neurologic; neurological; nutcase; pericarditis; pilots; poison; qtardfantasy; quack; qvirus; rare; rona; sads; safelydefective; semicallcenter; spikeprotein; stroke; strokes; substackingdollars; suddenly; suicides; trypanophobia; vaccine; vaccineinjury; vax; vaxx; vaxxed; vaxxes
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To: The Duke; Paladin2

Nattokinase is part of the (FLCCC) protocol mentioned in the link I posted, upthread.


41 posted on 04/07/2023 8:56:28 PM PDT by Jane Long (What we were told was a conspiracy theory in ‘20 is now fact. Land of the sheep, home of the knaves)
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To: Arcadian Empire

Thx!


42 posted on 04/07/2023 8:56:51 PM PDT by Jane Long (What we were told was a conspiracy theory in ‘20 is now fact. Land of the sheep, home of the knaves)
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To: george76

So when you go to the paper cited as proving the argument you see this:

“bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.”

https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1

And what exactly is bioRxiv?

“bioRxiv is an open access preprint repository for the biological sciences co-founded by John Inglis and Richard Sever in November 2013. It is hosted by the Cold Spring Harbor Laboratory. As preprints, papers hosted on bioRxiv are not peer-reviewed, but undergo basic screening and checked against plagiarism.”

It’s a preprint, so its claims have never been peer reviewed.

And What is the purpose of preprints?

“A preprint is a manuscript prepared for publication as a journal article that gets shared prior to peer review by a journal. Publishing preprints enables the immediate sharing of research results so the searcher doesn’t have to wait so long to find out about research that’s already been done.
Feb 6, 2023”

When you go to the bioRxiv webpage you also see this bottom right:

“Supported by Chan Zuckerberg Initiative”


43 posted on 04/07/2023 9:12:36 PM PDT by Pelham (Joe Biden, Brain of the American Left)
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To: semimojo

“Just because the grifter Dr. Makis lies about the paper’s implications doesn’t mean you need to lap it up.”

But the koolaid that Makis is serving is so tasty!


44 posted on 04/07/2023 9:16:28 PM PDT by Pelham (Joe Biden, Brain of the American Left)
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To: Pelham

The very reputable CSH Laboratory is now tied to the Chan Zuckerberg Initiative?


45 posted on 04/07/2023 9:17:18 PM PDT by FreeReign
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To: TigersEye

Thank you.

Myocarditis: Once Rare, Now Common..

In October 2022, the FAA quietly changed the electrocardiogram (“ECG”) parameters for pilots to accommodate people who have cardiac injuries. the vaxx causing a huge number of pilots to fail their screening.


46 posted on 04/07/2023 9:21:48 PM PDT by george76 (Ward Churchill : Fake Indian, Fake Scholarship, and Fake Art)
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To: george76

You’re welcome. Pretty scary isn’t it?


47 posted on 04/07/2023 9:25:35 PM PDT by TigersEye (Woke is a cancer of the mind and humanity)
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To: Jane Long; ransomnote; SecAmndmt; Jan_Sobieski; bagster; Roman_War_Criminal; aMorePerfectUnion; ...

What the $hot $hill$ seem to deliberately choose to ignore in regard to the *vaxxes* is that for all their hysteria over the damage done to the body from Covid because of the spike proteins, is the fact that the spike proteins are what is CAUSING the damage, and so they advocate for directly and purposefully injecting ONLY the spike proteins in the body in a claimed attempt to protect the person from Covid with it’s dastardly spike proteins.

Because you know, that the spike proteins that are attached to the Covid virus are far more serious and deadly than the spike proteins alone, by themselves.

Makes sense. Right?

In a pig’s eye.


48 posted on 04/07/2023 9:27:03 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith….)
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To: semimojo

Yes indeed. And we have Pavlovian responses from the usual delegation of FRistians demonstrating their ever present tolerance and witness of love. I wonder if the high priestess over there ever has an independent thought. The right reverend is early in tonight. Perhaps just waiting to pounce. Coven night does seem to be on Friday.


49 posted on 04/07/2023 9:35:32 PM PDT by gas_dr (Conditions of Socratic debate: Intelligence, Candor, and Good Will )
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To: metmom

It was always incongruous to claim that injecting people with deadly spike proteins was a healthy response to viruses that are covered with deadly spike proteins.


50 posted on 04/07/2023 9:36:37 PM PDT by Arcadian Empire (The Baric-Daszak-Fauci spike protein, by itself, is deadly.)
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To: All
German Health Minister: Covid Shots Cause ‘Permanent Severe Disabilities’ Slay News March 22, 2023
51 posted on 04/07/2023 9:37:20 PM PDT by TigersEye (Woke is a cancer of the mind and humanity)
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To: OHPatriot

Ummm. You didn’t read it very well. This is an opinion article about a preprint paper where the commentary is not offered by the author. This commentary cherry picks quote from a paper than then offers “my take” on the issues where everything you quoted comes from. Scientific papers never use the phrase “I believe”. If anything the authors refer to “our interpretation”.


52 posted on 04/07/2023 9:39:27 PM PDT by gas_dr (Conditions of Socratic debate: Intelligence, Candor, and Good Will )
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To: george76

Fasting has actually been shown to have benefits. It increases autophagy mechanisms and cleans up the body of dead cells and their components. The spike proteins can be “cleaned up” as part of these body recycling processes.


53 posted on 04/07/2023 9:46:26 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: FreeReign

Here’s the link to the bioRxiv webpage:

https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1

Scroll down to the bottom right and you’ll see “Supported by Chan Zuckerberg Initiative”

CZI isn’t listed on the bioRxiv advisory board so it may just be financial, for what that’s worth. But it is there. Here’s the advisory board:

https://www.biorxiv.org/content/about-biorxiv

The fact that this is a non-peer reviewed preprint paper is more significant. The paper is only two days old. No one has had a chance to examine the authors’ work or a chance to attempt to replicate their findings.

The paper itself carries this warning in a bright yellow header:

“bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.”

and of course it’s being treated as conclusive here as confirmation bias claims routinely are.


54 posted on 04/07/2023 9:53:59 PM PDT by Pelham (Joe Biden, Brain of the American Left)
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To: metmom

“Because you know, that the spike proteins that are attached to the Covid virus are far more serious and deadly than the spike proteins alone, by themselves.”

That would require the vaccine spike proteins to be different so that they don’t shape-shift like the wild virus spikes do. Oh wait... they are different in exactly that way! Damn. That ruins another stupid kook theory.


55 posted on 04/07/2023 10:03:32 PM PDT by Pelham (Joe Biden, Brain of the American Left)
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To: Pelham
The fact that this is a non-peer reviewed preprint paper is more significant. The paper is only two days old. No one has had a chance to examine the authors’ work or a chance to attempt to replicate their findings.

I agree with that.

Not sure how much the Chan Zuckerberg Initiative has effected the good reputation of CSH Lab. I would hope that it hasn't.

56 posted on 04/07/2023 10:05:27 PM PDT by FreeReign
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To: FreeReign

I suspect that Chan Zuckerberg Initiative probably throws money at most research labs. Research labs always need funding.

At least we know that they are present somehow; whether or not that ends up co-opting the lab is something that always has to be considered.

CZI isn’t on the advisory board so that’s in Cold Harbors’ favor.


57 posted on 04/07/2023 10:20:55 PM PDT by Pelham (Joe Biden, Brain of the American Left)
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To: george76

What about the J&J vaccine?

Was it not included in the research or were the results different?


58 posted on 04/07/2023 11:25:02 PM PDT by tired&retired (Blessings )
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To: george76

Wonderful. So glad I let mom nag me into getting it.


59 posted on 04/08/2023 3:44:13 AM PDT by GrandJediMasterYoda (As long as Hillary Clinton remains free, the USA will never have equal justice under the law)
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To: semimojo

Re spike protein in the brain:

How long does it take the mRNA to turn off completely and stop making residual spike protein in the body?

If the answer isn’t certain, there’s another possible source, rather than infection, for long term spike protein generation.

My take on the mRNA technology is that it may eventually be wonderful, but it ain’t there yet. It seems clear that it forces the body to keep pumping out whatever it delivers (spike protein here) and that it is difficult to control and to turn off.


60 posted on 04/08/2023 5:50:19 AM PDT by Pearls Before Swine
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