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A Risk in Cholesterol Drugs Is Detected, but Is It Real?
WSJ ^ | 7-3-07 | Avery Johnson

Posted on 07/03/2007 3:00:09 PM PDT by Dysart

As he examined data on a computer one day last fall, drug-safety reviewer Ralph Edwards saw something that concerned him: Of 172 people in his database who developed Lou Gehrig's disease or something similar while taking prescription medicines, 40 had been on statins, the huge-selling cholesterol drugs.

Dr. Edwards, director of the World Health Organization's drug-monitoring center, has amassed about four million reports of medical problems experienced by people taking prescription drugs. His job is to sift through these so-called adverse events, looking for "signals" of potential side effects.

The number of Lou Gehrig's cases associated with statins struck Dr. ...

(Excerpt) Read more at online.wsj.com ...


TOPICS: News/Current Events
KEYWORDS: als; health; statins
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This is a little disconcerting and definitely needs more research.
1 posted on 07/03/2007 3:00:12 PM PDT by Dysart
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To: Dysart

Disconcerting to you perhaps but there are trial lawyers like Edwards who have just been presented a potential gold mine.


2 posted on 07/03/2007 3:03:02 PM PDT by spald
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To: Dysart
There is a lot of info about these drugs and liver disease. Stay off the joy juice if you take them or you might be taking the ultimate cholesterol treatment.
3 posted on 07/03/2007 3:04:58 PM PDT by bybybill (HUNT RINOS IN THE PRIMARIES, SKIN RATS IN THE FALL)
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To: Dysart
Why do the “All American Wieners” think their life should be perfect with no risk what so ever? I suggest these people move to never never land where the two neurons represent the total sum of their brain power have gone.

Articles like these are the reason the dope heads with communication degrees from big ten schools like PSU have jobs; the only other jobs they would be capable of holding down are those in Mexico, doing the jobs Mexicans don’t want to do!

4 posted on 07/03/2007 3:08:31 PM PDT by Herakles (Diversity is code word for anti-white racism)
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To: bybybill

Yeah, I understand that perilous mixture— gave up the firewater quite some time ago. No drug is without some risks, but I estimate the benefits outweigh the risks with this drug, esp at low doses.


5 posted on 07/03/2007 3:13:17 PM PDT by Dysart
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To: Dysart
"This is a little disconcerting and definitely needs more research."

Sure does. The drug testing protocols have experienced past problems.

6 posted on 07/03/2007 3:16:34 PM PDT by ex-snook ("But above all things, truth beareth away the victory.")
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To: spald

Who knows, there could be a cure for cancer out there that isn’t being released because of the potential for lawsuits. Nothing in life can be completely safe (even staying in bed can cause bed sores), but the John Edwards of the world are determined to keep us in the dark ages (for a profit).


7 posted on 07/03/2007 3:19:34 PM PDT by scan59 (Let consumers dictate market policies. Government just gets in the way.)
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To: Dysart

If you have the data on what drugs people take, and what diseases they contract, a computer should be able to pop up any statistical correlations fairly quickly. That is only the beginning, however, as much more investigation would be required.


8 posted on 07/03/2007 3:20:04 PM PDT by csn vinnie
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To: Dysart
If You Want To Feel Younger, Forget Your Statins
9 posted on 07/03/2007 3:20:19 PM PDT by blam (Secure the border and enforce the law)
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To: Dysart

Sheesh!

Last panel: LDL 72, HDL 52, TC 160.

Down from heart attack threatening levels.

Ain’t much one can do that doesn’t carry some risk. But my statins? FMCDH!


10 posted on 07/03/2007 3:22:47 PM PDT by Ole Okie
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To: ex-snook; y'all
The full article goes on to suggest(per one researcher)that if you begin to experience any ALS-like symptoms while on a statin, you might want to stop taking it because there is some evidence that the disease process could be halted or delayed if caught early.
11 posted on 07/03/2007 3:31:23 PM PDT by Dysart
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To: Dysart

BTTT!


12 posted on 07/03/2007 3:35:14 PM PDT by PGalt
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To: Ole Okie
Yes, you do have to view in context that statins probably prevent many deaths from heart attacks—the leading killer-- against the potential of contracting a still very rare disease in ALS from the use of statins.
13 posted on 07/03/2007 3:36:06 PM PDT by Dysart
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To: Herakles
Why do the “All American Wieners” think their life should be perfect with no risk what so ever?

How did you conclude that from this article?

14 posted on 07/03/2007 3:39:08 PM PDT by Glenn (Free Venezuela!)
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To: blam
Thanks for the link which I missed. The truth is that I go back and forth in my position on statins. Not normally a trait of mine, btw. I have compromised for the time being and am taking my Lipitor every other night, rather than every night. My doctor doesn’t even know of my regimen and my bloodwork has been excellent, fwiw.
15 posted on 07/03/2007 3:43:14 PM PDT by Dysart
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To: Dysart

From the Mayo Clinic web site:

There is no evidence of a link between statins and amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

ALS is a serious degenerative neurological disorder that is due to disease and death of the nerve cells in the brain and spinal cord that control voluntary muscles. ALS may begin with muscle twitching, weakness in an arm or leg, or changes in speech (dysarthria). Eventually, it affects the ability to control the muscles needed to move, speak, eat and breathe.

Statins are medications prescribed for the treatment of high cholesterol. These medications can sometimes cause muscle pain (myalgia), muscle weakness and rarely severe muscle damage (rhabdomyolysis). But these occur as a result of direct muscle damage, not damage to nerve cells.


16 posted on 07/03/2007 3:51:07 PM PDT by Eva (I)
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To: spald
Disconcerting to you perhaps but there are trial lawyers like Edwards who have just been presented a potential gold mine.

In this particular instance it may be justified. I have been saying for year that when the statin issue explodes, it will be bigger than thalidomide, the Schiley Heart Valve, and everything since.

The cholesterol goalposts keep being moved downward. Billions and billions are at stake. Ideally, _everyone_ should take them, according to the manufacturer-backed researchers. Try to get follow-on funding if you find otherwise.

There is nothing altruistic about these compounds.

In 1998, the US Food and Drug Administration (FDA) placed a ban on the sale of dietary supplements derived from red yeast rice, which naturally contains lovastatin, arguing that products containing prescription agents require drug approval.

Now the door was open for patenting and mass marketing.

I and my wife have first hand experience with side effects that are serious, and references to these keep popping up everywhere.

Something is wrong here. And even if it takes the Silk Pony to do it, someday there will be a lot of stockholders in these manufacturers leaping from windows, and companies are going to be held accountable.

17 posted on 07/03/2007 3:57:50 PM PDT by Gorzaloon (Global Warming: A New Kind Of Scientology for the Rest Of Us.)
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To: Dysart
It is very likely that the Statin class agents accelerated the symptomatic awareness of the ALS presentation. Statins not uncommonly cause a mild general paresis. This is not usually a problem unless something else is going on.

A person may well have ALS for years prior to it becoming clinically obvious. The interval to awareness may be accelerated by the statin, but not likely the ALS itself.

I have observed this correlation in persons already known to have ALS. If put on a statin, the symptoms were clearly magnified. If the statins removed, the symptoms revert to their prior baseline.

I suspect this correlation is what is being demonstrated in the researcher's statistics.

18 posted on 07/03/2007 3:59:37 PM PDT by HangnJudge
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To: bybybill
"There is a lot of info about these drugs and liver disease."

I was taking Lipitor but it was causing my liver enzymes to run amok. I don't drink alcoholic beverages because I'm also diabetic and take thyroid and hypertension medications. Since I've been off the Lipitor, they've checked my liver function on two separate occasions and they were normal both times. And fortunately, I've been able to keep my cholesterol level within normal range by just watching what I eat.

19 posted on 07/03/2007 4:05:17 PM PDT by mass55th (Courage is being scared to death - but saddling up anyway~~John Wayne)
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To: HangnJudge
I have observed this correlation in persons already known to have ALS. If put on a statin, the symptoms were clearly magnified. If the statins removed, the symptoms revert to their prior baseline. I suspect this correlation is what is being demonstrated in the researcher's statistics.

Very interesting.

20 posted on 07/03/2007 4:06:38 PM PDT by Dysart
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