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Could intravenous antivirals be a last-ditch treatment for swine flu?
LA Times ^ | September 3, 2009 | Thomas H. Maugh II

Posted on 09/05/2009 10:36:27 PM PDT by neverdem

An unlicensed intravenous form of the antiviral drug Relenza saved the life of a woman with a severe illness resulting from infection by the pandemic H1N1 influenza virus, British doctors reported today in the journal Lancet. Dr. Michael Kidd and Dr. Mervyn Singer of the University College London Hospitals were treating the virus, commonly known as swine flu, in a 22-year-old woman who had contracted it after undergoing chemotherapy for Hodgkin's disease.

The woman had increasing shortness of breath, build-up of fluid in both lungs and was progressively deteriorating. Physicians had given her Tamiflu and Relenza, which is normally given in an inhalable form. Neither was effective, and on the 16th day of her stay in the intensive care unit, the doctors decided to try an experimental form of Relenza that is given intravenously. Permission for the experiment was given by the hospital and the woman's relatives, and the drug was supplied by the manufacturer, GlaxoSmithKline. Her condition improved within 48 hours and she was discharged from the ICU on the 24th day. The doctors speculated that neither the inhaled Relenza nor the oral Tamiflu were reaching the infection deep in her lungs...

(Excerpt) Read more at latimesblogs.latimes.com ...


TOPICS: Culture/Society; Extended News; News/Current Events; United Kingdom
KEYWORDS: antiviral; antivirals; flu; h1n1; influenza; intravenous; lastditch; lastresort; relenza; resort; swineah1n1; swineflu; swineh1n1; treatment
H1N1 pneumonitis treated with intravenous zanamivir

FReebie if you are registered.

1 posted on 09/05/2009 10:36:28 PM PDT by neverdem
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To: neverdem
Could intravenous antivirals be a last-ditch treatment for swine flu?

Mandatory ones?

2 posted on 09/05/2009 10:40:22 PM PDT by the invisib1e hand (hang the Czars.)
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To: the invisib1e hand

3 posted on 09/05/2009 10:42:10 PM PDT by Roscoe Karns
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To: Roscoe Karns

beer, the wd-40 of domestic policy.


4 posted on 09/05/2009 10:48:10 PM PDT by the invisib1e hand (hang the Czars.)
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To: Roscoe Karns

LOL!

Great!


5 posted on 09/05/2009 10:54:17 PM PDT by Eaker (If you have a problem and If explosives are an option then explosives are THE answer.)
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To: neverdem

Great news!


6 posted on 09/05/2009 11:03:25 PM PDT by rawhide
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
micro ping - comment# 1 links the Lancet case report.

Two NSAIDs, celecoxib aka Celebrex, and mesalazine, an aspirin derivative, show promise.

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus.

Zanamivir alone reduced viral load but not inflammation and mortality. The survival benefits of adding celecoxib and mesalazine to zanamivir could be caused by their synergistic effects in reducing cytokine dysfunction and preventing apoptosis.

New HIV vaccine hope

7 posted on 09/05/2009 11:39:09 PM PDT by neverdem (Xin loi minh oi)
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To: neverdem

OK, the doctors used heroic measures to save the life of a woman who already was immunocompromised and at risk. That doesn’t mean the same therapy will be successful the next time.


8 posted on 09/06/2009 7:23:13 AM PDT by Sarajevo (You're jealous because the voices only talk to me.)
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