Skip to comments.Simple molecule could prevent, alleviate pre-diabetes
Posted on 06/24/2018 6:59:46 AM PDT by ConservativeMind
Levels of CoQ and the presence of insulin resistance were analysed in a range of experimental laboratory settings, mouse models and samples from humans, as part of an ambitious research collaboration conducted with the University of Sydney, Victor Chang Cardiac Research Institute, Duke University School of Medicine, Garvan Institute of Medical Research, Genentech Inc. and the University of New South Wales.
Concentrations of CoQ were found to be lower in insulin resistant body fat and muscle tissue. When the researchers replenished CoQ, insulin resistance or pre-diabetes was reversed.
"CoQ is found in mitochondria, the power plants in the cells of our body, where it is required for the flow of electricity to the cell's 'motor' which is responsible for energy production," he explained.
"Energy production can also generate reactive chemical species -- often referred to as 'reactive oxygen species' or 'oxidants' -- as by-products, which can be damaging to cells.
"Previous studies have shown that these oxidants can cause insulin resistance. Our study has found that lower mitochondrial CoQ enhanced oxidant formation by mitochondria.
"Importantly, by replenishing CoQ in mitochondria, either in cells or in animals, we were able to restore 'normal' mitochondrial oxidants and reverse insulin resistance."
Published in eLife today, the research provides a missing link in our understanding of how changes in our diet can trigger insulin resistance, said co-lead author Professor David James, Leonard P. Ullmann Chair of Metabolic Systems Biology at the University of Sydney's Charles Perkins Centre.
"Eating a high fat, high sugar diet has long been known to be a major risk factor for obesity and pre-diabetes and our latest work brings us one step closer to understanding how and why," Professor James explained.
"However, oral CoQ supplements may not effectively restore mitochondrial CoQ due to its low absorption," Professor Stocker explained.
(Excerpt) Read more at sciencedaily.com ...
Why can’t these people just lose some weight? Sen. Tom Colburn said diabetes was 50% preventable. An ounce of prevention... BTW diabetes runs in my family. 2-3 had type 1. Those folks are real screwed.
I take Lipitor. My doctor has never said anything about CoQ10. Ive red I should be taking it. I am also type 2. Is this MitoQ safe?
“There is an expensive form of CoQ10 called, MitoQ. It does directly migrate into the mitochondria 700-1000 times more than normal CoQ10.”
Many thanks for posting the article and this info!
Here’s some info about it that I found:
Doesn’t insulin resistance make it difficult for people to lose weight?
I took Lipitor at one time. I think it caused my foot neuropathy.
There is a ubiquinol at Costco that doesnt require eating with fat, but it works because of about 100 mg of Polysorbate 80 is there as an emulsifier. People can develop allergies to Polysorbate 80.
My wife and I started taking MitoQ three weeks ago to test it out.
Thanks. I’ll check into it.
Does anyone know about the benefits of alpha lipoic acid? It is used in Europe to treat diabetes.
>>My wife and I started taking MitoQ three weeks ago to test it out.<<
How is it looking?
We get little exercise and our appetite is now in line with that amount of activity. With carbs, we could always feel like eating something more.
The MitoQ is definitely not hurting us, but I cannot point to it for any immediate benefit. In theory, it should be building up in our mitochondria and help us over time by keeping them healthy and younger.
That's what I've always thought. After knowing diabetics in my family and friends, it seems obvious that diabetes is a type of addiction in some people.
Many diabetics crave sugar and will binge on it. I've seen diabetics binge and then give themselves a couple of injections of insulin to compensate, like that was going to fix everything.
Also, when you've been close to diabetics, it's easy to notice when they've been "good" and when they've been off their feed. The mood swings and personality changes will tip you off.
It reminds me of alcoholism, and I bet someday they will show a tie. You can plead with some diabetics, show them the facts, everything. You will get denial, and indignation: "it's my life and I can do what I want", "So what if it kills me, we've all got to die", etc. etc.
I mention all this not to impugn diabetics but to share my thoughts that it is a mystery in many of the same ways as alcoholism, and maybe just as tough a fight to beat it.
The Wikipedia reference is useful:
The form our body actually uses is the R-ALA version. It is a racemic molecule (right handed or left handed) and only one exists in nature. Normal manufactured ALA is roughly equal S-ALA and R-ALA.
Do you think there’s any benefit to people already diagnosed with diabetes? My son-in-law was diagnosed two years ago and he’s in his 40s, lean, and quite fit. He also does the sugar binge thing then medicates himself. Disturbing to watch. :(
If you decrease your bodies caloric intake and absorption you will lose weight(you can even maintain same foods and exercise level). It is best to decrease caloric intake and eat nutritionally dense foods AND increase exercise if possible. It might be painful from hunger pains and feelings of weakness etc..and difficult to maintain a diet with less available calories but you will lose weight.
As a general rule for each 10 calories lost on a daily basis (every day) one will lose 1 pound in a year. 12 oz. sugared soda is approximatrly 120 cals (some are more)..but if one drinks one of those daily but then stops that practice and maintains every thing dietarily the same...that one can lose 12 pounds in a year. If same person increases ecercise by lets say 120 cals a day....and drops the soda also...well...24 lbs a year. Its that simple as a general rule. It is difficult to maintain daily discipline but if you do...you WILL lose weight.
You cannot manufacture tissue from pure air and pure water. Remember the Biafrans? Did any of them have difficulty losing weight due to insulin resistance?
I understand the sugar, of course, and have given that up. But many people swear that if you're diabetic or pre-diabetic, you should eat a "high fat, low carb" diet. Is fat good or not?
“..it seems obvious that diabetes is a type of addiction in some people.”
Sorry, no. Wish it was. Diabetes is a disease caused not by choice, but by the failure of the body to work within it’s needs.
Weight is not the cause of the illness, it is a part of the affliction. I’m six feet one, and when I was diagnosed with type II I weighed 175 pounds and was easily passing all my physical fitness requirements for the military along with playing sports like basketball, racquetball, and baseball/softball. I was as fit as I could possibly be with a less than 4% body fat measurement according to military doctors.
But because my body was not producing insulin that worked, my body failed to get the use out of the fuel I was consuming. So I wasn’t cutting back on food to lose weight, I was starving the body of nutrients and fuel.
Diets and even starvation will not work as your body will adjust to dampen the failure of muscle use due to lack of fuel until you starve to death. But that doesn’t make your body work correctly.
It actually invites the body to adjust until it will start to shut down functions, or, starvation sepsis. According to Clinical Nutrition ESPEN, a European medical group that studies body needs, food intake in humans is an intermittent process but energy is expended continually. Therefore, humans adapt well to short-term starvation. But the body will break down and start to shut down functions when it is starving of fuel. And all the protein, and other elements you normally consume will not stop it.
And that is the problem diabetics face daily in that balance of consuming enough fuel to live, but not gain or lose weight when the body decides for you that it isn’t going to use the fuel you provided and turns it into fat, or in hypo cases, sends it out of the body. Meantime, you feel like you are exhausted, and the weight adds to the problem as the body doesn’t break it down for use because of the lack of insulin and the insulin you have doesn’t work well.
It’s a delicate balance that you can’t keep up with because of outside needs. And those needs happen from moment to moment in most cases.
Sounds like a better bargain if it does not cost over 700-1000 times more.
bump for reference
Alpha lipoic acid is good stuff, but it is also a potent chelator of mercury. If you have mercury in dental work or accumulated in your body, you have to read up on the proper way to use alpha lipoic acid, or else you will just redistribute a lot of mercury, which could be very bad.
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