Posted on 04/25/2022 10:50:48 AM PDT by ConservativeMind
A calorie-reduced diet can not only delay the development of metabolic diseases, but also has a positive effect on the immune system. Researchers have now shown for the first time that this effect is mediated by an altered gut microbiome, which slows down the deterioration of the immune system in old age (immune senescence).
Around 2 billion people worldwide are overweight. Obesity increases the risk of developing high blood pressure, heart attack or type 2 diabetes mellitus and can cause inflammation in the body that weakens the immune system through an accumulation of specific memory T and B cells. This process is called immune senescence, an age-related change in the immune system. In obese people, the development of metabolic diseases such as type 2 diabetes can be delayed by a low-calorie diet. In addition, such a diet also has a positive effect on the immune system. But exactly how the positive effects are mediated and what role the gut microbiome plays in this process is not known. Researchers have now investigated the interactions between calorie-reduced diets, the microbiome, metabolism and the immune system.
For this purpose, they first analyzed how a very low-calorie diet (800 kcal/day for 8 weeks) affected the gut microbiome of an obese woman. In the next step, the researchers transplanted the gut microbiota before and after the diet intervention into germ-free mice to establish a gnotobiotic mouse model.
By transplanting the diet-altered microbiota, glucose metabolism improved and fat deposition decreased. In addition, mass cytometry showed that the level of specific memory T and B cells was also reduced. "This indicates delayed immune senescence," said Julia Sbierski-Kind, first author of the study.
"These findings suggest that the positive effects of a low-calorie diet on metabolism and the immune system are mediated via the gut microbiome," Sbierski-Kind said.
(Excerpt) Read more at medicalxpress.com ...
Based on...what? Humans lived on much lower calories for thousands of years. Only in the past two centuries have Westerners been told they need "2,860 calories per day" or what have you, by the USDA or other incompetent authorities who were likely lobbied to do so. And obestity rates EXPLODED. It's all a lie. We do not need this many calories at all, and intermittent fasting is critical to good health as well.
People would look like Monty Burns...
It’s a great way to crush your metabolism and become amazingly weak. I’m currently “cutting”. I’m at 2000-2500 calories.
These people are insane.
bkmk
Green with envy. I love golf, only sport I watch on TV. Took lessons years ago but I’m so astigmatic I couldn’t find the ball. If I had better vision, I’d play and need to eat more than 800 calories..
Eat twice/day and often forget to eat. Don’t count calories and don’t need to. When the idiot governor closed the gyms where healthy people go to stay healthy, I lost muscle tone and my appetite. Getting back into shape gradually and then may need “more than 800 calories” per day.
I think forgetting to eat may be part of aging. Same old food, year after year, boring. Natural Grocer is helpful, just moved into my ‘hood and have shelves full of delish stuff that suits my food prejudices: no gluten, no pork, no this, no that. Their stuff is pricey but delish. It’s noon here and I’m enjoying chicken sausage links and gluten-free toaster waffles with butter and pure maple syrup. Yum.
IF is good, particularly down to a 4-6 hr feeding window. But 800 is obviously unsustainable past the rapid weight loss phrase. Even Okinawans pre 1960 averaged 1500-1800 a day. The longest lived people on earth and aren’t vegetarians by any stretch.
bookmark
Yes. I know all about lean gains. He loads up on large amounts of BCAAs right before the workout at the end of the fasting period though.
That is a good point.
All this is creating is disordered thinking about food.
People have such a bad relationship with food. Almost like enjoyment doesn’t enter their minds. I often say, “we think so much about ‘not dying’, we have forgotten about actually ‘living’”.
Great question!
I believe we already have them in very tiny amounts and the diet completely changes up what dominates.
I agree and it’s crazy. I sort of flip flop from mainly Paleo nutrition to actual Italy foods.
I bust my butt lifting, swimming, and sprinting, so I remain lean/muscular.
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