A low-calorie diet alters the gut microbiome and delays immune aging (Gut bacteria controls metabolism and immune system)

Medical Xpress / University of Tübingen / Microbiome ^ | Apr. 22, 2022 | Julia Sbierski-Kind et al

[ConservativeMind]

A calorie-reduced diet can not only delay the development of metabolic diseases, but also has a positive effect on the immune system. Researchers have now shown for the first time that this effect is mediated by an altered gut microbiome, which slows down the deterioration of the immune system in old age (immune senescence).

Around 2 billion people worldwide are overweight. Obesity increases the risk of developing high blood pressure, heart attack or type 2 diabetes mellitus and can cause inflammation in the body that weakens the immune system through an accumulation of specific memory T and B cells. This process is called immune senescence, an age-related change in the immune system. In obese people, the development of metabolic diseases such as type 2 diabetes can be delayed by a low-calorie diet. In addition, such a diet also has a positive effect on the immune system. But exactly how the positive effects are mediated and what role the gut microbiome plays in this process is not known. Researchers have now investigated the interactions between calorie-reduced diets, the microbiome, metabolism and the immune system.

For this purpose, they first analyzed how a very low-calorie diet (800 kcal/day for 8 weeks) affected the gut microbiome of an obese woman. In the next step, the researchers transplanted the gut microbiota before and after the diet intervention into germ-free mice to establish a gnotobiotic mouse model.

By transplanting the diet-altered microbiota, glucose metabolism improved and fat deposition decreased. In addition, mass cytometry showed that the level of specific memory T and B cells was also reduced. "This indicates delayed immune senescence," said Julia Sbierski-Kind, first author of the study.

"These findings suggest that the positive effects of a low-calorie diet on metabolism and the immune system are mediated via the gut microbiome," Sbierski-Kind said.

[ConservativeMind]

Getting down to 800 calories a day, like this subject did, is nearly a “fasting-like” diet, but one does not need to go to such lengths to change up the bacteria in our gut.

It is interesting they posited the bacteria would change this favorably and be responsible for such body changes, outside of the loss of calories. The mice given the changed bacteria had the benefit without changing their diet.

[ConservativeMind]

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[Faith65]

Thanks.
BKMK

[ProtectOurFreedom]

800 calories per day? Yikes! My target is 1,800 and that’s hard to achieve.

“Around 2 billion people worldwide are overweight.” There’s a huge amount of fear being broadcast about upcoming food shortages, so maybe this problem will take care of itself.

[BiglyCommentary]

So you can go to the all you can eat buffet as long as you sprinkle some skinny gut flora on your food....

[impimp]

these posts are amazing for “health lurkers” like me - thanks

[Jonty30]

I’d rather have a full belly than a long life and an empty belly.

[Codeflier]

They’re getting ready to tell people worldwide that food shortages are a good thing.

800 calories a day! Good luck in the gym lifting weights. LOL. We live among such promoted insanity these days.

[NWFree]

Was this written to prepare us for the Biden famine? 🤪

[BiglyCommentary]

There was an earlier article about food processing plants being set on fire as a form of food terrorism and my thought was the only terrorism going on for many is against the weight bearing components of their bathroom scales.

[BiglyCommentary]

Actually lifting during the fast period of one’s day is supposed to yield better results.

[Codeflier]

Not when your muscle glycogen is nearly depleted. All I can say is good luck.

[Born in 1950]

How do you know?

[Jonty30]

I’m a creature of comforts.

[E. Pluribus Unum]

800 calories a day is plenty for a 70 pound person.

[FLNittany]

You need more than 800 calories a day. Many more - some in the form of Yuengling.

Walk. WALK. Be on your feet more than on your seat.

I just sold out of my biz and took a coveted job at a local private golf club. Lots of tour players. Lots of activity. Great membership - mostly young - that throw money around like crazy.

Couldn’t be happier. At my age I wondered what could keep me young, and I figured it out.

[Trumpet 1]

So, like maybe I should eat/drink yogurt or cultured buttermilk or kefir or sweet acidophilus milk? Just checking. These bacteria have to come from somewhere eh?!

[Ezekiel]

Was this written to prepare us for the Biden famine?

Sardonic wit, the breakfast of champions.

[BiglyCommentary]

TRF = Time restricted feeding. ND = normal diet

“Performance wise, TRF clearly outperformed ND. Low-responders in both groups increased their bench press by merely 4% in both groups, with the highest number reaching +12.2% in ND, and an impressive +22.7% in TRF. “

https://leangains.com/intermittent-fasting-and-lifting-finally-a-study/

[erlayman]

I am all for time restricted eating but it doesn’t even seem safe to lose weight that quickly. Rapid weight loss through IF/CR could trigger gallstone problems for one thing.