Posted on 04/04/2024 9:32:50 PM PDT by ConservativeMind
New research conducted in mice offers insights into what's going on at the molecular level that could cause people with diabetes to develop Alzheimer's disease.
The study adds to a growing body of research on the links between type 2 diabetes and Alzheimer's disease, which some scientists have called "type 3 diabetes." The findings suggest that it should be possible to reduce the risk of Alzheimer's by keeping diabetes well controlled or avoiding it in the first place, according to researchers.
Narendra Kumar led the study.
"We think that diabetes and Alzheimer's disease are strongly linked," Kumar said, "and by taking preventative or amelioration measures for diabetes, we can prevent or at least significantly slow down the progression of the symptoms of dementia in Alzheimer's disease."
Diet is known to influence the development of diabetes as well as the severity of its health impacts.
They found that a high-fat diet suppresses the expression of the protein, called Jak3, and that mice without this protein experienced a cascade of inflammation starting with the intestine, moving through the liver and on to the brain. Ultimately, the mice showed signs of Alzheimer's-like symptoms in the brain, including an overexpressed mouse beta-amyloid and hyperphosphorylated tau, as well as evidence of cognitive impairment.
"Liver being the metabolizer for everything we eat, we think that the path from gut to the brain goes through liver," Kumar said.
His lab has been studying functions of Jak3 for a long time, he added, and they now know that the impact of food on the changes in the expression of Jak3 leads to leaky gut. This in turn results in low-grade chronic inflammation, diabetes, decreased ability of the brain to clear its toxic substances and dementia-like symptoms seen in Alzheimer's disease.
(Excerpt) Read more at medicalxpress.com ...
You can eat either high carb, or high fat....you cannot do both.
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You can live without carbohydrates but you must eat a certain amount of fats. For most a low carbohydrate diet would be best.
“You can eat either high carb, or high fat....you cannot do both.”
Uh, why not? If my lunch is a Big Mac, fries and a Coke, wouldn’t that be a high-carb meal and a high-fat meal?
The understood, but unstated part...."and stay healthy". If you have ANY "flavor" of diabetes...STOP EATING CARBS. Type 2 can be fully reversed (I did it). Type 1 will benefit.
Wow. /s The institutional stupidity on health never ceases to amaze me.
Isn’t a “high fat” diet bad for heart disease?
Just another reason to eat as healthy as possible.
No. This is a fraud scientific perpetrated by Ancel Keys. The primary driver for heart problems is excess carbohydrate.
No.
Ancel Keys is responsible for even more deaths than Fauci.
True dat... probably by factors of 10 or greater.
Diabetes and ‘abusing your liver’ ran through both sides of my Family of Origin. My Dad’s side had more issues with Dementia than Mom’s.
They were a lot of fun while it lasted, though. ;)
It stopped with me. :)
HDHs = Good,
LDLs = Bad.
And as far as the LDLs go, only the small, dense LDLs are bad.
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