'Stress' protein could halt aging process, say scientists

University of Liverpool ^ | May 24, 2010 | Unknown

[decimon]

HSP10 (Heat Shock Protein), helps monitor and organise protein interactions in the body, and responds to environmental stresses, such as exercise and infection, by increasing its production inside cells. Researchers at Liverpool, in collaboration with colleagues at the University of California, found that excessive amounts of HSP10 inside mitochondria – 'organs' that act as energy generators in cells – can halt the body's ageing process by preserving muscle strength.

HSP10 occurs naturally in all living organisms and scientists believe that study into its functions could prove significant for the design of future health care for the elderly, who are particularly susceptible to muscle damage. Researchers examined the role HSP10 plays inside cells, to further understand how ageing muscle tissue can recover from stress.

Professor Anne McArdle, from the University's School of Clinical Sciences, said: "We studied the role of HSP10 inside mitochondria, as it is here that unstable chemicals are produced which can harm parts of the cell. The damage caused by this is thought to play an important part in the ageing process, in which skeletal muscle becomes smaller and weaker and more susceptible to stress damage.

"In response to these stresses HSP10 increases its levels and helps cells resist damage and recover more effectively. Our research is the first to demonstrate that age-related loss of skeletal muscle mass is not inevitable and this could have considerable implications for the future health care of the elderly. Between the ages of 50 and 70 we lose approximately 25-30% of our muscle. Falls – a major cause of injury and death in people over the age of 65 – are often the direct result of loss of mobility and weakened skeletal muscle.

"We now need to look at how we might artificially increase production of HSP10 in the body, specifically in relation to ageing muscle, to see if the protein could be used as a therapeutic measure. In time, clinical trials must take place to establish what benefits HSP10 can have on human quality of life, such as preservation of muscle strength."

###

The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), is published in the American Journal of Physiology.

[decimon]

Shock and awe ping.

[mainsail that]

“Stress’ protein could halt aging process, say scientists”

Social Security Administration states that messing with ‘stress’ protein causes cancer

:)

[Neoliberalnot]

Interesting article. Thanks for posting. Any idea what stimulates the production of HSP10? Resistance training maybe?

[decimon]

Any idea what stimulates the production of HSP10?

Stress? ;-)

I'm thinking we may want to get our HSP10, if we want it, by other than natural means.

[Mariner]

Weight training is the fountain of youth.

[SunkenCiv]

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[Monkey Face]

I’ll volunteer if they’ll guarantee I can remain ageless for the next five years... ;o]

[colorado tanker]

Is he looking any younger yet?

[Bellflower]

Any idea what stimulates the production of HSP10? Resistance training maybe?

Infrared sauna treatment. The site linked below is informative. I use a good par 30 LED light (one that has Cree products built into it is best, I think). All you have to do is lay it on the area you want to treat for 10 to 20 minutes or more at a time for some amazing results. These are cool LED lights. You can also buy or create a whole LED sauna.

Also if you are very careful as they are extremely hot you can use the red heat lamp light you can buy at hardware stores and sit close enough to it to feel the heat well but NOT close enough to burn yourself. Again, you must be extremely careful handling the hot heat lamp bulb as they really are flaming hot and easily can cause a lot of damage if mishandled.

http://www.drlwilson.com/articles/sauna_therapy.htm

If you want to read a fairly informative book I think that this is the book I read several years back. You just have to be prepared to wade through some new age BS.

http://drlwilson.com/Books/saunabook.htm

[neverdem]

Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle cross-sectional area.

[Lee'sGhost]

Seems to be working for me. Of course, I’ve been lifting for more that 30 years. At 55 I’m almost strictly maintenance mode...no more “body building”... but what I’m maintaining looks pretty damn good compared to the soft pudgy 25 year olds I see.

Running helps too. Every other day, 4 miles, give the joints time to recover.

[Hot Tabasco]

I’ve been lifting for more that 30 years. At 55 I

I said the same thing when I was your age kid! Now I'm almost 60. Alot really happens in just 4 years.....Maybe it was the loss of stress when I retired at the end of 2006 that has deprived me of that stress protein.......LOL!

[bannie]

My dad lives on stress (he loves it!). He’s 90.

My mom doesn’t stress. She’s 90.

[Thombo2]

Thanx for the ping.

[SunkenCiv]

My pleasure.