Skip to comments.Researchers discover why olive oil lessens breast cancer risk
Posted on 02/15/2005 6:29:56 PM PST by nickcarraway
[Health India]: Washington, Jan 10 : A team of researchers from the Northwestern University Feinberg School of Medicine in Chicago, have revealed why Mediterranean diets, which include a lot of olive oil, reduces breast cancer risk in women.
The study, which has been published in the "Annals of Oncology" also found evidence that oleic acid, which is found in olive oil, may have a future role in treatment.
The researchers said that oleic acid dramatically cuts the levels of an oncogene called Her-2/neu, also known as erb B-2. High levels of Her-2/neu occur in over a fifth of breast cancer patients and are associated with highly aggressive tumours that have a poor prognosis.
Not only did oleic acid suppress over-expression of the gene, other tests on the cell lines showed that it also boosted the effectiveness of trastuzumab (Herceptin), the monoclonal antibody treatment that targets the Her-2/neu gene and has helped to prolong the lives of many breast cancer patients.
They said that the dietary monounsaturated fatty acid which significantly down-regulates the expression of Her-2/neu, cutting it by up to 46 percent. Her-2/neu is one of the most important oncogenes in breast cancer.
Their tests also revealed that oleic acid's inhibition of Her- 2/neu synergistically interacted with Herceptin-based immunotherapy by promoting the death of breast cancer cells exhibiting high levels of the oncogene.
Additionally, alongside the sensitising effect of oleic acid on the efficacy of Herceptin it was found that it increased the expression of a protein (p27Kip1), a tumour suppresser protein, which is implicated in the development of resistance to Herceptin treatment.
Yeah I thought it was something like that.
Dang, taken internally. I was going to ask the Mrs. Beancounter if I could apply it for her.
You don't have to tell her.
Because she doesn't have any?
(That joke is so filthy, I can't tell it here.)
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