Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Researchers discover why olive oil lessens breast cancer risk
newkerala ^ | Jan 10

Posted on 02/15/2005 6:29:56 PM PST by nickcarraway

[Health India]: Washington, Jan 10 : A team of researchers from the Northwestern University Feinberg School of Medicine in Chicago, have revealed why Mediterranean diets, which include a lot of olive oil, reduces breast cancer risk in women.

The study, which has been published in the "Annals of Oncology" also found evidence that oleic acid, which is found in olive oil, may have a future role in treatment.

The researchers said that oleic acid dramatically cuts the levels of an oncogene called Her-2/neu, also known as erb B-2. High levels of Her-2/neu occur in over a fifth of breast cancer patients and are associated with highly aggressive tumours that have a poor prognosis.

Not only did oleic acid suppress over-expression of the gene, other tests on the cell lines showed that it also boosted the effectiveness of trastuzumab (Herceptin), the monoclonal antibody treatment that targets the Her-2/neu gene and has helped to prolong the lives of many breast cancer patients.

They said that the dietary monounsaturated fatty acid which significantly down-regulates the expression of Her-2/neu, cutting it by up to 46 percent. Her-2/neu is one of the most important oncogenes in breast cancer.

Their tests also revealed that oleic acid's inhibition of Her- 2/neu synergistically interacted with Herceptin-based immunotherapy by promoting the death of breast cancer cells exhibiting high levels of the oncogene.

Additionally, alongside the sensitising effect of oleic acid on the efficacy of Herceptin it was found that it increased the expression of a protein (p27Kip1), a tumour suppresser protein, which is implicated in the development of resistance to Herceptin treatment.


TOPICS: Food; Health/Medicine
KEYWORDS: breastcancer; cancer; health; oliveoil; research

1 posted on 02/15/2005 6:29:59 PM PST by nickcarraway
[ Post Reply | Private Reply | View Replies]

To: nickcarraway
The researchers said that oleic acid dramatically cuts the levels of an oncogene called Her-2/neu, also known as erb B-2.

Yeah I thought it was something like that.

2 posted on 02/15/2005 6:35:16 PM PST by BipolarBob (Yes I backed over the vampire, but I swear I didn't see it in my rearview mirror.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: BipolarBob

Dang, taken internally. I was going to ask the Mrs. Beancounter if I could apply it for her.


3 posted on 02/15/2005 6:39:07 PM PST by gov_bean_ counter
[ Post Reply | Private Reply | To 2 | View Replies]

To: gov_bean_ counter

You don't have to tell her.


4 posted on 02/15/2005 6:40:55 PM PST by BipolarBob (Yes I backed over the vampire, but I swear I didn't see it in my rearview mirror.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: nickcarraway
Researchers discover why olive oil Olice Oyl lessens breast cancer risk

Because she doesn't have any?


5 posted on 02/15/2005 6:45:28 PM PST by BykrBayb (5 minutes of prayer for Terri, every day at 11 am EDT, until she's safe. http://www.terrisfight.org)
[ Post Reply | Private Reply | To 1 | View Replies]

To: BykrBayb
According to Popeye, she also prevents rust.

(That joke is so filthy, I can't tell it here.)

6 posted on 02/15/2005 6:48:59 PM PST by atomicpossum (Replies should be as pedantic as possible. I love that so much.)
[ Post Reply | Private Reply | To 5 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson