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Scientists Find Clues to Aging in a Red Wine Ingredientís Role in Activating a Protein
NY Times ^ | November 27, 2008 | NICHOLAS WADE

Posted on 11/26/2008 11:03:14 PM PST by neverdem

A new insight into the reason for aging has been gained by scientists trying to understand how resveratrol, a minor ingredient of red wine, improves the health and lifespan of laboratory mice. They believe that the integrity of chromosomes is compromised as people age, and that resveratrol works by activating a protein known as sirtuin that restores the chromosomes to health.

The finding, published online Wednesday in the journal Cell, is from a group led by David Sinclair of the Harvard Medical School. It is part of a growing effort by biologists to understand the sirtuins and other powerful agents that control the settings on the living cell’s metabolism, like its handling of fats and response to insulin.

Researchers are just beginning to figure out how these agents work and how to manipulate them, hoping that they can develop drugs to enhance resistance to disease and to retard aging.

Sirtris, a company Dr. Sinclair helped found, has developed a number of chemicals that mimic resveratrol and are potentially more suitable as drugs since they activate sirtuin at much lower doses than resveratrol. This month, one of these chemicals was reported in the journal Cell Metabolism to protect mice on fatty diets from getting obese and to enhance their endurance in treadmills, just as resveratrol does.

Though the sirtuin field holds considerable promise, the dust has far from settled. Resveratrol is a powerful agent with many different effects, only some of which are exerted through sirtuin. So drugs that activate sirtuin may not be as splendid a tonic for people as resveratrol certainly seems to be for mice.

The new finding concerns maintenance of the chromosomes, the giant molecules of DNA that make up the genome...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: aging; diet; genetics; genomics; health; medicine; nutrition; oenology; resveratrol; sirt1; sirtuin; wine
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during

By clicking on the keyword sirtuin, you can get an older article on resveratrol.

1 posted on 11/26/2008 11:03:15 PM PST by neverdem
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To: neverdem

Interesting story. This research all started with the French Paradox and a couple of years ago they confirmed that resveratrol has these effects on yeast. Looks like they’ve now progressed to mice. It will be interesting if the effect is the same with other mammals, like humans...


2 posted on 11/26/2008 11:21:24 PM PST by ableRivet
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To: neverdem
I don't know why the emphasis is always on wine. Wine gets it's reservratrol from GRAPES - So why would not grapes be just as effective - and grape juice? Certainly less expensive.

http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/

3 posted on 11/26/2008 11:44:37 PM PST by maine-iac7 ("He has the right to criticize who has the heart to help" Lincoln)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
The Catch-22 of Aging

NHS want to close smoking room for terminally ill patients in Birmingham

Curing Diversity - The new medicine shows that we’re biochemically separate and unequal—and regulators are starting to catch on.

FReepmail me if you want on or off my health and science ping list.

4 posted on 11/27/2008 12:33:38 AM PST by neverdem (Xin loi min oi)
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To: neverdem

A few weeks ago I heard that while red wine was good for you in moderation, the red wine from Italy, Argentina (and one other place down there) was particularly free of certain metals they were finding in wines outside of those areas.


5 posted on 11/27/2008 12:53:35 AM PST by Edgewood Pilot
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To: maine-iac7

It all boils down to anti-oxidents ... find the most powerful and efficacious .. I used to MLM pycnogenol ... works wonderful, but too many people think all mlm is AMWAY, so it’s a tough sell.


6 posted on 11/27/2008 2:13:51 AM PST by knarf (I say things that are true ... I have no proof ... but they're true.)
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To: maine-iac7

but not as enjoyable.


7 posted on 11/27/2008 3:06:53 AM PST by henry_reardon
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To: knarf

Is there a commonality with other purple fruits; blueberries, blackberries, etc ?


8 posted on 11/27/2008 4:35:03 AM PST by Eric in the Ozarks
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To: Eric in the Ozarks

Ive read bluberries are high in antioxidants.


9 posted on 11/27/2008 5:26:19 AM PST by DeusExMachina05 (I will not go into Dhimmitude quietly.)
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To: Edgewood Pilot
A few weeks ago I heard that while red wine was good for you in moderation, the red wine from Italy, Argentina (and one other place down there) was particularly free of certain metals they were finding in wines outside of those areas.

Probably Chile

10 posted on 11/27/2008 5:59:39 AM PST by Aria ("An America that could elect Sarah Palin might still save itself." Vin Suprynowicz)
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To: neverdem

There are some interesting articles in this search.

http://search.yahoo.com/search?ei=utf-8&fr=slv8-hptb5&p=resveratrol%20grape%20juice&type=


11 posted on 11/27/2008 6:50:12 AM PST by Grampa Dave (This is the link to Leo Donofrio's new website: http://thenaturalborncitizen.blogspot.com)
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Ck


12 posted on 11/27/2008 7:01:18 AM PST by jla (Sarah - True heir of Reagan conservatism)
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To: DeusExMachina05

The Cocoa bean is 11 times higher in antioxidants than blueberries.


13 posted on 11/27/2008 11:26:31 AM PST by Balata
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To: ConservativeMind

Ping for later.


14 posted on 11/27/2008 4:51:49 PM PST by ConservativeMind (Obama is bringing in every crook and bumbler he can to assure consistency in his message.)
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To: maine-iac7
I don't know why the emphasis is always on wine. Wine gets it's reservratrol from GRAPES - So why would not grapes be just as effective - and grape juice? Certainly less expensive.

I've wondered about that too. Sad the MSM accepts everything without question when it's "research" from a liberal institution. Don't journalists have any sense of curiosity anymore?

15 posted on 11/28/2008 4:09:47 AM PST by GOPJ (The CITI/ financial dike has sprung 500 leaks - we need an engineer - not more fingers.)
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To: GOPJ
I've wondered about that too. Sad the MSM accepts everything without question when it's "research" from a liberal institution. Don't journalists have any sense of curiosity anymore?

No. (And I worked my last 20 years before retirement in the business.)

Journalists today remind me of the car designers - instead of doing your own work and using your own mind - you steal designs/stories from the competition. Ergo - we get mongrel cars and the same story regurgitated from the primary source through all the outlets - with no fact checking or research.

Indeed, we are now a world of second-handers.

16 posted on 11/28/2008 6:56:34 PM PST by maine-iac7 ("He has the right to criticize who has the heart to help" Lincoln)
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