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"Atkins Hormone" Discovered
Chemistry World ^ | 05 June 2007

Posted on 06/08/2007 8:07:29 PM PDT by Paradox

'Atkins hormone' discovered


05 June 2007

They are loved and endorsed by celebrities and dismissed as an unhealthy diet craze by critics. But 'low carb', high protein and high fat diets have proven their metabolic worth: scientists in the US have discovered a fat-burning role for a specific hormone stimulated by these eating regimes. The work has also raised the intriguing question of whether the Atkins diet could make you live longer. 

A group of researchers led by Steven Kliewer at Southwestern University in Dallas, Texas found that a growth hormone called fibroblast growth factor 21 (FGF21) stimulates fat metabolism in the liver. 

Cutting out the carbs
Do mice on the Atkins diet live longer?
At the same time, Eleftheria Maratos-Flier and her colleagues from Boston University found that a ketogenic diet, low in carbohydrates and relatively high in fat, stimulated the production of this hormone. Both studies are published simultaneously in Cell Metabolism

'It was one of those serendipitous discoveries,' Kliewer told Chemistry World. 'We were studying receptors in the liver that are activated by fatty acids, and we found that the receptors, called PPARalpha, regulate the hormone FGF21, so we went on to study what FGF21 does.' 

Kliewer's treated mice with FGF21, either by genetic modification or direct injection, and said that it made the animals look like they were starving. 'It turned on a starvation response, even when the animals were feeding. They switched from using carbohydrates to fat stores as an energy supply,' he said.

Maratos-Flier's group fed their mice a high fat, low carbohydrate diet for 30 days and found that levels of FGF21 increased.  

This biochemical deception, causing the body to burn fat even when on a high fat diet, is a weight loss method made famous by Robert Atkins, who died in 2003. Such diets are called ketogenic because, without a source of carbohydrate to produce energy, fats or lipids are metabolised, producing ketones as a replacement fuel.

Starving to stay younger

Although previous work linked FGF21 to metabolism, Kliewer's work illustrates its fat burning function for the first time. 'This is one of the most exciting things I've ever worked on,' he said. 'Starvation and restricted diet are linked to some fascinating physiology including longevity. In the long term, I would like to investigate the role of FGF21 in ageing, since caloric restriction has been linked to an extended life span in many species.'

David Moore from Baylor College of Medicine in Houston, Texas described the link between calorie restriction and longevity as a 'tantalising' research area.

'When you starve an overweight body, you see many metabolic benefits, including increased fat metabolism, some of which could be mediated by FGF21,' Moore told Chemistry World. 'There was a study described at a conference recently, where a morbidly obese child undertook a medically supervised 300 day fast. He lost half his body weight and was reported to be physically fine.'

Moore pointed out that in all species tested so far, including worms, birds, rodents and dogs, restricting calorie intake leads to a longer life span (see Chemistry World, May 2007, p24). But a long term longevity study in humans is a huge practical challenge.

Eric Ravussin from Pennington Biomedical Research Center in Louisiana has pinpointed a number of biomarkers for ageing that he says could start to answer the question of whether a ketogenic diet or FGF21 increases life span. 'This type of diet or this hormone could provide a surrogate for calorie restriction,' he suggested.

References

M K Badman et alCell Metab., 2007, DOI: 10.1016/j.cmet.2007.05

T Inagaki et alCell Metab., 2007, DOI: 10.1016/j.cmet.2007.05.003 



TOPICS: Health/Medicine
KEYWORDS: atkins; atkinsdiet; diet; diets; ketosis; lowcarb; lowcarbdiet; nutrition
Looks like they have found the key to the Atkins/lowcarb diets. I have seen many recent studies basically saying that lowcarb diets work. Science is finally catching up to something alot of people have known for years, if not decades, and that is that a low-carb diet can be a useful diet for some people.
1 posted on 06/08/2007 8:07:30 PM PDT by Paradox
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To: Paradox

Low-carbing worked for me, I lost 60 pounds in 9 months, but over the ensuing three years I put it all back on. I’m trying it again, I’m not sure how much weight I’ve lost in the past month but I’m down at least an inch on my waist.

I’ve never understood why people get so my-way-or-the-highway about diets, anyhow. There’s lots of different ways to lose weight, from just cutting portion size, to low-carb, to low-fat, to Nutrisystem-style plans that supply all the food. Find one that works FOR YOU and that you can stick with, and get some exercise. It’s easier said than done, that’s for sure!

}:-)4


2 posted on 06/08/2007 8:10:41 PM PDT by Moose4 (Just junk all across the horizon, a real highwayman's farewell...)
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To: Paradox

I’ve followed the scientific reports on low carbing very closely and am satisfied that it’s healthy and effective if you can stick to it.

But that’s the problem- it’s harder for me to stay on a low carb diet than it is a restricted calorie diet. It doesn’t matter how healthy the diet is if you can’t stick to it.


3 posted on 06/08/2007 8:18:09 PM PDT by MittFan08 (Anybody but McCain)
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To: Paradox

Atkins was grossly fat, and had significant heart disease when he died.

Perhaps moderation, and moderation in moderation is the key?

Just saying....


4 posted on 06/08/2007 8:41:41 PM PDT by donmeaker (You may not be interested in War but War is interested in you.)
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To: Paradox

mark


5 posted on 06/08/2007 9:35:56 PM PDT by Ladysmith ((NRA, SAS) 9/11: Many of us REFUSE to Forget!!)
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To: donmeaker

*sigh*

And the Barbra Streisand concerning Dr. Atkin’s death continues...


6 posted on 06/08/2007 9:37:20 PM PDT by Ladysmith ((NRA, SAS) 9/11: Many of us REFUSE to Forget!!)
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To: Paradox

Do the Inuit have a long, earthly lifespan? Their traditional diet is very high in protein and fat, and low in carbohydrates. That should give some clues as to whether an Atkin’s diet could increase earthly lifespans.


7 posted on 06/09/2007 3:01:31 AM PDT by Jedi Master Pikachu ( What is your take on Acts 15:20 (abstaining from blood) about eating meat? Could you freepmail?)
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To: donmeaker

So I’m wondering...you lose weight but die of heart disease from the high fat diet??
I don’t diet. I have a lifestyle eating program, in other words, this is the way i will live, not the way i lose weight.
And i’m losing, slowly.


8 posted on 06/09/2007 5:04:56 AM PDT by Shimmer128 (I see dumb people. They're everywhere. They don't even know they're dumb.)
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To: Shimmer128
Actually, I don't do Atkins myself, but I do stay away from refined carbs as much as possible. All the research into lowcarb diets indicates that it does NOT cause any more heart disease than any other diet. What really matters is how much you eat, really. Low-carb diets do reduce blood sugar, insulin, and triglyceride levels, which in and of themselves cause a whole host of cardiovascular problems.

There really isn't much debate left, as others say, its your lifestyle that you need to change. Any significant weight loss will introduce metabolism changes which will have to be dealt with for life, by, basically, eating less and doing more, forever.

9 posted on 06/09/2007 5:33:44 AM PDT by Paradox (In the final analysis, its mostly a team sport, Principles cast off like yesterdays free agents.)
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To: Coleus; AdmSmith; Berosus; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; ...
'low carb', high protein and high fat diets have proven their metabolic worth: scientists in the US have discovered a fat-burning role for a specific hormone stimulated by these eating regimes. The work has also raised the intriguing question of whether the Atkins diet could make you live longer.
I feel smug, having finally bought Dr Atkins' book for a buck apiece (like new, three copies, two editions) at the library.
10 posted on 06/09/2007 9:28:56 AM PDT by SunkenCiv (Time heals all wounds, particularly when they're not yours. Profile updated June 8, 2007.)
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To: Paradox
I've always been skeptical of "fads" like this but the low-carb (I prefer to call it "normal-carb") lifestyle is what finally caused me to lose my excess weight and I've kept it off for three years now.

Eliminated processed foods with high fructose corn syrup and hydrogenated oils is half the battle. The foods left over are pretty much good foods to eat on this normal-carb lifestyle. Meats, fishes, eggs, nuts, cheese, olive oil, green vegetables, yogurt, red wine...

11 posted on 06/09/2007 9:34:45 AM PDT by SamAdams76 (I am 94 days away from outliving Marvin Gaye)
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To: SunkenCiv

I feel skeptical. Even if such a hormone as is in mice is found in humans, that doesn’t mean it acts the same way.

Not to say their work is of no value. It sure gives another researcher something to look at.

Intriguing question is it.


12 posted on 06/09/2007 10:56:14 AM PDT by donmeaker (You may not be interested in War but War is interested in you.)
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To: SunkenCiv; Paradox; All
Lots of Fat, No Carbs--And the Right Hormone had two interesting links that I glanced over.

A primer on fat metabolism

Check out the effect of ketogenic diets on epilepsy.

Most folks know the simplest ketone, acetone, the main ingredient in nail polish remover.

13 posted on 06/09/2007 11:12:29 AM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: donmeaker
Atkins was grossly fat, and had significant heart disease when he died.

That group that put out the silly stats sure got a lot of milage from it. Go back and look the reality up.

14 posted on 06/09/2007 1:08:50 PM PDT by lepton ("It is useless to attempt to reason a man out of a thing he was never reasoned into"--Jonathan Swift)
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To: donmeaker

Oh. Just to be a little more specific, when Atkins was admitted to the hospital, he was about 6’ tall, about 195 lbs. and in his 70s. The group that put out the description you cite was a Vegan group.


15 posted on 06/09/2007 1:19:14 PM PDT by lepton ("It is useless to attempt to reason a man out of a thing he was never reasoned into"--Jonathan Swift)
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To: SunkenCiv; DixieOklahoma; reuben barruchstein; theprophetyellszambolamboromo; Alusch; ...

.


16 posted on 06/09/2007 1:26:00 PM PDT by Coleus (Woe unto him that call evil good and good evil"-- Isaiah 5:20-21)
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To: Paradox

http://paleodiet.com/

http://www.westonaprice.org/traditional_diets/caveman_cuisine.html


17 posted on 06/09/2007 1:48:39 PM PDT by Coleus (Woe unto him that call evil good and good evil"-- Isaiah 5:20-21)
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To: donmeaker

Atkins was grossly fat, and had significant heart disease when he died. >>

Atkins was husky and not “grossly” overweight. Overweight yes, obese no. Most of his life he maintained his weight. And, btw, doctors are not immortal and do die.

And, who ever said that doctors practice what they preach. When I was a kid, my doctor had no smoking signs all over his office and when you entered his private office, what was he doing? Smoking. He told my mother, “you don’t see any No Smoking signs in here do you?”


18 posted on 06/09/2007 1:54:03 PM PDT by Coleus (Woe unto him that call evil good and good evil"-- Isaiah 5:20-21)
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To: donmeaker

I heard he died of a head injury nothing else was wrong with him.


19 posted on 06/09/2007 1:58:16 PM PDT by television is just wrong (Amnesty is when you allow them to return to their country of origin without prosecution.)
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To: lepton
"Oh. Just to be a little more specific, when Atkins was admitted to the hospital, he was about 6’ tall, about 195 lbs. and in his 70s. The group that put out the description you cite was a Vegan group.">

Atkins was tall and broad. He wasn't "fat" let alone "grossly obese." And, he did NOT have heart disease. He WAS, however, a practicing cardiologist, who discovered that his patients got WELL on a low-carbohydrate diet.

He died of head injuries sustained when he slipped on winter ice outside his New York offce. I'm very sorry to disappoint those vegans, but they will have to come up with a different dead horse to beat.

20 posted on 06/09/2007 2:14:00 PM PDT by redhead ("Ah works dirty, but Ah does a clean job..." --Nightmare Alice in Li'l Abner)
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To: donmeaker

That’s completely false.


21 posted on 06/09/2007 2:18:06 PM PDT by Sloth (The GOP is to DemonRats in politics as Michael Jackson is to Jeffrey Dahmer in babysitting.)
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To: Paradox

I eat high complex carbs and am losing. The carbs are important. Very low refined carbs, high complex carbs. :)
Very low fat
Very low salt
Very low sugar
Foods as grown (lots of veggies and fruit, not necessarily raw though)


22 posted on 06/09/2007 3:06:05 PM PDT by Shimmer128 (My beloved is mine and I am his Song of Sol. 2:16)
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To: Sloth

Dr. Robert Eckel of the American Heart Association says that high-protein, low-carbohydrate diets put people at risk of heart disease [7]; however, a long term study published in the New England Journal of Medicine in 2006 found that women reduced heart disease risk by eating more protein and fat from vegetable sources [8].
A 2001 scientific review by Obesity Research magazine concluded that low-carb dieters’ initial advantage in weight loss was a result of increased water loss, and that after the initial period, low-carb diets produce similar fat loss to other diets with similar caloric intake. [9]
The May 2004 Annals of Internal Medicine study showed that Atkins Dieters had significantly more diarrhea, general weakness, rashes and muscle cramps. Atkins.com now suggests a fiber supplement.
Also, acidity from the typically high protein intake may cause osteoporosis in women.[3]

On July 31, 2005, the Atkins Nutritional company filed for Chapter 11 bankruptcy protection after the percentage of adults on the diet declined to two percent and sales of Atkins brand product fell steeply in the second half of 2004.


23 posted on 06/09/2007 3:10:48 PM PDT by donmeaker (You may not be interested in War but War is interested in you.)
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To: redhead

round 2000, Atkins started to develop a heart condition, cardiomyopathy, which he claimed was unrelated to his diet.[1][2] On April 18, 2002, Atkins suffered a cardiac arrest. He made a recovery and returned to work.

On April 8, 2003, Atkins slipped on ice and fell in front of his medical office in New York City and sustained major head injuries that put him in a coma. News of this quickly turned into rumors that Atkins had a heart attack while he was on his own diet. He never recovered from his injuries, and subsequently died on April 17 of kidney failure.[3] By mistake, the New York City Medical Examiner’s Office released Atkins’ medical records to the Physicians Committee for Responsible Medicine, a group associated with PETA and which advocates a vegetarian diet. The record stated his weight to be approximately 255 lb (116 kg) at the time of death.[2] In terms of simple height/weight measure (BMI), this would mean he was obese; the apparent irony of a diet guru being obese caused the information to be circulated around the world by the media and animal rights groups, much to the distress of his family. The Atkins company released a statement claiming that he weighed only 196 lb (89 kg) upon admission to the hospital and that his apparent increase in weight was due to fluid retention following the failure of his major organs.[4] William Leith interviewed him in the period between his cardiac arrest and his fall. Leith writes, “He looks to be just under 6 feet tall and around 200 lbs – not skinny, not thin, but definitely not fat. The jowls around his neck are fairly minimal, signs of age rather than excess weight.”[5]


24 posted on 06/09/2007 3:17:50 PM PDT by donmeaker (You may not be interested in War but War is interested in you.)
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To: Sloth

Some people will throw mud at anything if it makes people pay attention to him.


25 posted on 06/09/2007 3:27:39 PM PDT by lainie ("You don't have a soul. You are a soul. You have a body." - C. S. Lewis)
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To: donmeaker

You are speading lies, no he wasn’t. I knew him, he was thin and looked great, I was on a cruise with him. Please check your facts.


26 posted on 06/09/2007 4:00:49 PM PDT by chicagolady (Mexican Elite say: EXPORT Poverty Let the American Taxpayer foot the bill !)
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To: chicagolady

Thank you, I thought that the poster was wrong about Dr. Atkins condition, but I just couldn’t remember the facts.

I do remember that a Harvard Medical study released a report a while back that confirmed the claims made by the Atkins Diet to be all true.


27 posted on 06/09/2007 6:03:39 PM PDT by Eva
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To: donmeaker
I'm not one to defend "Atkins", because I don't advocate the strict form of his diet, even the latter day Atkins diet was far more flexible than most people know. But he was definately on to something. The diet changed as time went on, with high fiber vegetables being OK to eat.

All those drawbacks listed are easily taken care of by eating some carbs once you lose the weight, and the more scientific versions of the diet (Lyle McDonalds "The Ketogenic Diet") are a far cry from the "eat all the fat and meat you want" kind of thing.

28 posted on 06/10/2007 6:33:36 AM PDT by Paradox (In the final analysis, its mostly a team sport, Principles cast off like yesterdays free agents.)
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To: chicagolady

Please do me a favor, and stop in to Wikipedia and change their entry on Dr. Atkins.

A lie is when you know it is wrong. I don’t know that it is. I am repeating what I have read.

Feel free to also remark on how flat chested you find Demi Moore and Pamela Andersen.


29 posted on 06/10/2007 7:42:43 PM PDT by donmeaker (You may not be interested in War but War is interested in you.)
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