3-D Structure Of Human Genome: Fractal Globule Architecture Packs Two Meters Of DNA Into Each Cell

ScienceDaily ^ | Thursday, October 8, 2009 | Adapted from original article written by Steve Bradt, Harvard University

[SunkenCiv]

...they describe a new technology called Hi-C and apply it to answer the thorny question of how each of our cells stows some three billion base pairs of DNA while maintaining access to functionally crucial segments... says co-first author Erez Lieberman-Aiden... "But if the double helix didn't fold further, the genome in each cell would be two meters long. Scientists have not really understood how the double helix folds to fit into the nucleus of a human cell, which is only about a hundredth of a millimeter in diameter. This new approach enabled us to probe exactly that question." The researchers report two striking findings. First, the human genome is organized into two separate compartments, keeping active genes separate and accessible while sequestering unused DNA in a denser storage compartment. Chromosomes snake in and out of the two compartments repeatedly as their DNA alternates between active, gene-rich and inactive, gene-poor stretches. Second, at a finer scale, the genome adopts an unusual organization known in mathematics as a "fractal." [Image by Bang Wong, Broad Institute]

[SunkenCiv]

3-D Structure genome site:freerepublic.com

Google

[SunkenCiv]

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[muawiyah]

All of which has something to do with the fact you can flip a single basepair on a single gene on a single DNA strand and get yourself a PRIMAL DWARF rather than a more ordinary type human being.

[Boogieman]

Who says they are primal? Maybe they are secretly the future of humanity?

[neverdem]

thanks, bfl

[BwanaNdege]

"Nature's devised a stunningly elegant solution to storing information -- a super-dense, knot-free structure," says senior author Eric Lander...

"But if the double helix didn't fold further, the genome in each cell would be two meters long. Scientists have not really understood how the double helix folds to fit into the nucleus of a human cell, which is only about a hundredth of a millimeter in diameter."

These idiots refuse to recognize Design by a brilliant Engineer. IOW, this "elegant solution" did not just happen, God designed it.

[JoeProBono]

[coconutt2000]

These idiots refuse to recognize Design by a brilliant Engineer. IOW, this "elegant solution" did not just happen, God designed it.

Perhaps God designed it to just happen...

[Fractal Trader]

adopts an unusual organization known in mathematics as a "fractal"

Fractals are hardly unusual. They ARE the norm.

[eleni121]

What an amazing God He is.

[grey_whiskers]

I nominate you for the Nobel Peace Prize! /sarc>

Cheers!

[Eyes Unclouded]

These guys are no idiots, please control yourself. I have seen them present their work it is very exciting.

If we can understand how DNA sits in the cell fully we are well on our way to being able to target certain portions. This work is quite promising so don’t malign these guys. Whether or not God designed the DNA is irrelevant to figuring out exactly how it works. If your reverse engineering a watch you don’t really care who made it you just care how it works.