Posted on 04/17/2016 2:17:48 AM PDT by SunkenCiv
...In recent years, dental calculus has emerged as an unexpected, but valuable, long-term reservoir of ancient DNA from dietary and microbial sources... Very little dental calculus was required for analysis--fewer than 25 milligrams per individual. This makes it possible to obtain high quality genetic ancestry information from very little starting material, an important consideration for archaeological remains...
Although dental calculus preserves alongside skeletal remains, it is not actually a human tissue. Dental calculus, also known as tartar, is a calcified form of dental plaque that acquires human DNA and proteins passively, primarily through the saliva and other host secretions. Once mineralized within dental calculus, however, human DNA and proteins can preserve for thousands of years. Dental calculus thus serves as an important non-skeletal reservoir of ancient human DNA.
Conventional techniques for recovering ancient human DNA typically require the destruction of bone or tooth tissue during analysis, and this has been a cause of concern for many Native and indigenous communities. Dental calculus represents an important alternative source of ancient DNA that does not damage or disturb the integrity of skeletal remains. In addition, because dental calculus is the richest known source of DNA in the archaeological record, it presents unique opportunities for investigating archaeological sites with preservation challenges...
The demonstration that whole mitochondrial genomes can be reconstructed from small samples of dental calculus represents an important technological advancement for paleogenomic investigations in prehistoric North America and other regions where destructive analysis of skeletal remains is difficult or controversial.
(Excerpt) Read more at eurekalert.org ...
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