Free Republic
Browse · Search
Bloggers & Personal
Topics · Post Article

Interesting study that the lack of glucose may trigger the production of amyloid plaques.

It ties into theories that diabetes makes people more susceptable to Alzheimer's Disease.

How can you help?

Take your new Christmas computer or PS3 and download the Folding@home program, which will use your system to crunch proteins. Yes, you to can help find a cure for diseases such as Alzheimer's, Huntingdon's, cancers and AIDS by being part of a much larger distributed computer system.

Read on for more info, and ping me if you have any questions!

1 posted on 12/27/2008 10:07:58 PM PST by texas booster
[ Post Reply | Private Reply | View Replies ]


To: texas booster
Folding@Home FAQ for new users:

What is Folding@Home?
A Stanford University project to find out how proteins fold.

Why it's important: Proteins folding wrong causes all kinds of diseases, like Alzheimer's, Parkinson's, and forms of cancer. Folding@Home uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. Through Folding@home, scientists now have the horsepower to study the mechanics of protein folding. With its ability to share the workload among hundred of thousands of computers economically, Folding@home can help scientists understand how proteins snap, or don't, into their predestined shapes - and may help to explain the origins of diseases such as Alzheimer's and apparently unrelated diseases. We're fueling research that could end all that.


How does it work?: You download a safe, tested program (see link below) that is certified by Stanford University. It gets work from Stanford, runs calculations using your spare computer power, and sends the results back to the University.

Is it safe? Yes! Folding@Home rarely effects computer performance in any way and won't compromise your privacy in any way. It only uses the computing power you aren't using so it doesn't slow down other programs.


How do I get started folding for Team FreeRepublic?:
1.) Download the folding program from Stanford University's folding download page (Folding@home Client Download). Type in your desired user-name.
2.) Type in 36120 for the team number. THIS IS VERY IMPORTANT - if you get the number wrong, you won't be folding for team FreeRepublic!
3.) The third question asks, "Launch automatically at machine startup, installing this as a service?" - We recommend you answer YES. Otherwise you will have to manually start the program after every reboot.


How can my computer help? Even if they were given exclusive access to all of the world's supercomputers, Stanford still wouldn't have as much processing power as they get from the supercluster of people's desktop systems Folding@home relies on. Modern supercomputers are essentially a cluster of hundreds of processors linked by fast networking. But Stanford needed the power of hundreds of thousands of processors, not just hundreds.


There's no reason to not get involved! It's free, easy, and you can know you're helping every minute without lifting a finger.

*******************************************

List of Relevant Folding Links
Why Fold - Watch This !!


Another Folding Clip


The Inner Life of a Cell


Folding@home Client Download


FreeRepublic.com Folder Stats


Extreme Overclockers Stats for FreeRepublic


Another Stats Page


Folding@home New Forum


*******************************************
Competition (Not!!) Dummies ..Daily Kos


Dummie Folding Threads #7 #8 #9#10#11 #12
Hey DUmmies, can't ya'll post a new thread at least once a year?


**************************************************
Other Useful Stuff - Links


How much are those work units worth? And what are they?
All Projects Listed

Point Summary for Workunits


Stat Image Generator


Fahmon Third Party Monitoring Software

**************************************
Past FreeRepublic Folding threads


#1 #2 #3 #4 #5 #6 #7 #8 #9 #10 #11 #12 #13 #14 #15 #16 #17 #18 #19 #20 #21 #22 #23 #24 #25 #26 #27 #28 #29 #30 #31 #32 #33 #34 #35 #36 #37 #38 #39 #40 #41 #42 #43 #44 #45 #46 #47 #48 #49 #50


2 posted on 12/27/2008 10:10:11 PM PST by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: texas booster

Watching less of CBS, NBC, ABC, CNN, and etc, would go a long way to preventing brain starvation.


5 posted on 12/27/2008 10:19:34 PM PST by MahatmaGandu (Remember, remember, the twenty-sixth of November.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: All
SNIPPET from the link in post no. 1:

"A simple preventive strategy people can follow to improve blood flow to the brain is getting exercise, reducing cholesterol and managing hypertension."

6 posted on 12/27/2008 10:22:59 PM PST by Cindy
[ Post Reply | Private Reply | To 1 | View Replies ]

To: texas booster; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; ...
Interesting study that the lack of glucose may trigger the production of amyloid plaques.

It ties into theories that diabetes makes people more susceptable to Alzheimer's Disease.

Structure of enzyme offers treatment clues for diabetes, Alzheimer's

"Groundbreaking" Alzheimer's trial removes toxic brain plaques

There was no cognitive improvement. I have to wonder if the accumulation of amyloid plaques is just an effect, not the cause of the underlying pathology.

FReepmail me if you want on or off the diabetes ping list.

9 posted on 12/27/2008 10:58:08 PM PST by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: texas booster

Exercise daily, eat very little grain foods (maybe a couple slices of whole grain bread or some oatmeal a day), no sugar, no artificial foods, and take bioidentical hormones to replace yours to a young man’s or woman’s level.


15 posted on 12/28/2008 12:17:48 AM PST by Yaelle
[ Post Reply | Private Reply | To 1 | View Replies ]

To: texas booster

Very interesting study. As someone who has been personally touched by the ravages of this disease, it’s encouraging that this kind of research is being done.


20 posted on 12/28/2008 2:16:50 AM PST by RU88 (The false messiah can not change water into wine any more than he can get unity from diversity.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: texas booster

High blood glucose is a serious condition that, over time, causes severe damage to almost every part of the body - but produces NO immediate symptoms even with glucose levels several times normal.

LOW blood glucose, on the other hand, produces immediate, apparent, and severe reactions, including severe confusion, hallucinations, and unconsciousness. It is not uncommon for diabetics to have this problem when they fail to keep the balance of exercise, medication, and carbohydrate intake in proper balance. My stepfather had this problem naturally, and experienced this spontaneously a few times, including at his eldest daughter’s wedding.

I have neuropathy in both feet and lower legs, and 4 years ago I had an A1c of 7.6. My Dr. handed me a “diabetic diet” on 5 or 6 sheets of paper and prescribed a glucose meter for me to develop a baseline for treatment.

The diet was less than unappealing, and included a lot of carbs that I did not want to consume. I decided to just concentrate on reducing carb intake, with particular emphasis on the carbs that affected me most - sugar, of course, but also rice and potatoes. Bread and pasta are not quite as bad, so I have small amounts of these occasionally. And I do eat fruits daily, and a bowl of bran flakes every morning.

But I do NOT take any diabetes medication, my A1c is now 5.6, and my average glucose reading (morning and night, at least 2 hours after eating) for the past 30 days is 95.

95 is well below the 110 that is considered a good level, but is is good enough to protect from Alzheimers? It has not cured my neuropathy in 4 years. Is that because it still rises to higher levels immediately after each meal or snack, and only drops back after 2 hours? What is the effect of this on Alzheimer susceptibility?


23 posted on 12/28/2008 8:09:47 AM PST by MainFrame65 (The US Senate: World's greatest PREVARICATIVE body!.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: esquirette

psst . . . over here


27 posted on 12/29/2008 9:12:30 AM PST by RightField (A fine is a tax for doing wrong. A tax is a fine for doing well,.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: texas booster
Vassar said it also is possible that drugs could be designed to block the elF2alpha protein that begins the formation of the protein clumps, known as amyloid plaques.

Mucking with brain chemistry is always spooky - but this might work.

29 posted on 12/30/2008 7:44:05 AM PST by GOPJ (GM's market value is a third of Bed, Bath and Beyond. Why is GM "too big to fail"? Steyn)
[ Post Reply | Private Reply | To 1 | View Replies ]

Free Republic
Browse · Search
Bloggers & Personal
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson